gene

FAM134B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FAM134B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

482Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

FAM134B is an ER-phagy receptor associated with HSAN2 and Parkinson's disease

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🧬 Gene Info

Gene Symbol	FAM134B
Full Name	Family With Sequence Similarity 134 Member B
Chromosome	5
Protein Type	Receptor
Function	is a critical ER-phagy receptor protein that plays an essential role in endoplasmic reticulum quality control and turnover.
Primary Expression	Neurons, peripheral sensory neurons
Amino Acids	476 aa
Pathways	Autophagy, Innate Immunity
UniProt ID	Q9H6Y3
NCBI Gene ID	54494
Ensembl ID	ENSG00000144136
OMIM	613374
GeneCards	FAM134B
Human Protein Atlas	FAM134B
Band	p15.1
Associated Diseases	AD, ALI, Als, Alzheimer, dementia
Interactions	ABCD3, AKT, ALS, ALZHEIMER, ALZHEIMER DISEASE, AMBRA1
KG Connections	482 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: FAM134B — AlphaFold Q9H6Y3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

FAM134B — Family With Sequence Similarity 134 Member B

gene · 1033 words

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Pathway Diagram

flowchart TD
    FAM134B["FAM134B
ER-phagy Receptor"]
    
    %% ER Stress and Autophagy Pathway
    ER_Stress["ER Stress
Response"]
    EIF2AK3["EIF2AK3
(PERK)"]
    EIF2S1["EIF2S1
(eIF2alpha)"]
    CHOP["CHOP
Pro-apoptotic Factor"]
    
    %% Autophagy Components
    LC3["LC3
Autophagosome Marker"]
    ER_Phagy["ER-phagy
Process"]
    
    %% Mitochondrial Quality Control
    PRKN["PRKN
(Parkin)"]
    MUL1["MUL1
Mitochondrial Ligase"]
    MIRO1["MIRO1
Mitochondrial Transport"]
    DRP1["DRP1
Mitochondrial Fission"]
    
    %% Cell Death Pathways
    BCL2L11["BCL2L11
(BIM)"]
    BNIP3["BNIP3
Mitochondrial Death"]
    RIPK3["RIPK3
Necroptosis"]
    
    %% Neurodegeneration Outcomes
    ALS["Amyotrophic Lateral
Sclerosis"]
    Alzheimer["Alzheimer's
Disease"]
    Parkinson["Parkinson's
Disease"]
    FTD["Frontotemporal
Dementia"]
    
    %% Key Interactions
    FAM134B -->|"regulates"| ER_Phagy
    FAM134B -->|"binds"| LC3
    ER_Stress -->|"activates"| EIF2AK3
    EIF2AK3 -->|"phosphorylates"| EIF2S1
    EIF2S1 -->|"induces"| CHOP
    
    FAM134B -->|"interacts"| PRKN
    FAM134B -->|"interacts"| MUL1
    PRKN -->|"ubiquitinates"| MIRO1
    MUL1 -->|"regulates"| DRP1
    
    CHOP -->|"activates"| BCL2L11
    BCL2L11 -->|"promotes"| BNIP3
    RIPK3 -->|"triggers"| Cell_Death["Cell Death
Pathways"]
    
    ER_Phagy -->|"dysfunction"| ALS
    ER_Phagy -->|"dysfunction"| Alzheimer
    PRKN -->|"mutations"| Parkinson
    Cell_Death -->|"leads to"| FTD
    
    %% Styling
    style FAM134B fill:#006494
    style ER_Phagy fill:#1b5e20
    style LC3 fill:#1b5e20
    style PRKN fill:#4a1a6b
    style MUL1 fill:#4a1a6b
    style CHOP fill:#ef5350
    style BCL2L11 fill:#ef5350
    style BNIP3 fill:#ef5350
    style RIPK3 fill:#ef5350
    style ALS fill:#5d4400
    style Alzheimer fill:#5d4400
    style Parkinson fill:#5d4400
    style FTD fill:#5d4400

Outgoing (250)

Target	Relation	Type	Str
ER-phagy	promotes	process	0.95
ubiquitin-proteasome	participates_in	pathway	0.70
Ms	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Neuropathy	associated_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Neuropathy	causes	disease	0.65
ALS	interacts_with	disease	0.65
Ms	activates	disease	0.65
Cancer	regulates	disease	0.65
Carcinoma	regulates	disease	0.65
Ftd	interacts_with	disease	0.65
Glioblastoma	activates	disease	0.65
Als	activates	disease	0.65
Hepatocellular Carcinoma	regulates	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Proteostasis	activates	pathway	0.60
Mtor	activates	pathway	0.60
Lysosomal Degradation	activates	pathway	0.60
TRIM21	activates	gene	0.60
CANCER	regulates	gene	0.60
RETREG1	activates	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
Autophagy	activates	pathway	0.60
ATP	interacts_with	gene	0.60
PGAM5	interacts_with	gene	0.60
ALZHEIMER DISEASE	interacts_with	gene	0.60
Cell Cycle	interacts_with	pathway	0.60
Mitophagy	therapeutic_target	pathway	0.60
RETREG1	regulates	gene	0.60
GENES	activates	gene	0.60
MTORC1	activates	gene	0.60
PROTEIN MISFOLDING	activates	gene	0.60
FIP200	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
ALS	associated_with	disease	0.60
SESTRIN2	activates	gene	0.60
dementia	associated_with	disease	0.60
Parkinson	associated_with	disease	0.60
FMR1	interacts_with	gene	0.60
oxidative stress response	participates_in	pathway	0.60
ALS	activates	disease	0.60
LC3B	interacts_with	gene	0.60
Innate Immunity	regulates	pathway	0.60

Incoming (232)

Source	Relation	Type	Str
TFEB	upregulates	protein	0.95
XBP1	activates	gene	0.60
EPAS1	activates	entity	0.60
SESTRIN2	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
NLR	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
NIX	interacts_with	gene	0.60
RETREG1	interacts_with	gene	0.60
TRIM21	activates	gene	0.60
CATALASE	interacts_with	gene	0.60
EPAS1	interacts_with	gene	0.60
DNA	activates	gene	0.60
OPTN	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
LC3B	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
ALS	interacts_with	gene	0.60
PGAM5	interacts_with	gene	0.60
BIM	interacts_with	gene	0.60
RIP3	interacts_with	gene	0.60
AND	activates	gene	0.60
AMPK	activates	entity	0.60
RETREG1	stabilizes	gene	0.60
ATG	activates	gene	0.60
ATP	activates	gene	0.60
BIM	activates	gene	0.60
ERN1	interacts_with	gene	0.60
CAT	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
HIF1	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
CANCER	regulates	gene	0.60
PARKINSON	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
ATP	interacts_with	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
MITOPHAGY	interacts_with	gene	0.60
HIF	interacts_with	gene	0.60
DEMENTIA	interacts_with	gene	0.60
PRESENILIN	interacts_with	gene	0.60
AUTOPHAGY	regulates	gene	0.60
AND	inhibits	gene	0.60
AND	regulates	gene	0.60
ALS	activates	entity	0.60
AND	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FAM134B in their description or question text

No additional research found