gene

PERK

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PERK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

874Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

PERK is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, inhibits. Associated with AD, ALI, ALS. Connected to 269 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PERK
Protein Type	Kinase
Function	Stress sensing: Accumulation of unfolded proteins in the ER lumen
Subcellular Localization	the ER membrane. As one of the three major sensors of the unfolded protein response (UPR)
Molecular Weight	125 kDa
GeneCards	PERK
Human Protein Atlas	PERK
N-terminal luminal domain (1-576)	Senses misfolded proteins in the ER lumen; interacts with BiP/GRP78
Transmembrane domain (577-597)	Anchors PERK to ER membrane
Cytosolic kinase domain (666-1114)	Serine/threonine kinase activity; phosphorylates eIF2α
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	Dolutegravir, DTG, rapamycin, SB202190
Interactions	ABCA1, ABCA7, ABCD3, ACETYL-COA, ADSL, AGGF1
KG Connections	874 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PERK Protein

protein · 957 words

→

EIF2AK3 Protein (PERK)

protein · 1678 words

→

Pathway Diagram

graph TD
    PERK["PERK"] -->|"interacts"| Alzheimer["Alzheimer"]
    PERK["PERK"] -->|"interacts"| ALS["ALS"]
    PERK["PERK"] -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    PERK["PERK"] -->|"interacts"| Dementia["Dementia"]
    PERK["PERK"] -->|"interacts"| Cardiovascular["Cardiovascular"]
    PERK["PERK"] -->|"interacts"| Parkinson["Parkinson"]
    Dolutegravir["Dolutegravir"] -->|"activates"| PERK["PERK"]
    AGGF1["AGGF1"] -.->|"inhibits"| PERK["PERK"]
    BCL2L11["BCL2L11"] -->|"interacts"| PERK["PERK"]
    DNA["DNA"] -->|"interacts"| PERK["PERK"]
    style PERK fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (533)

Target	Relation	Type	Str
Endoplasmic Reticulum Stress	mediates	process	0.90
Cancer	activates	disease	0.85
Tumor	activates	disease	0.85
eIF2A	phosphorylates	protein	0.85
ATF4	upregulates	protein	0.85
Endoplasmic Reticulum Stress	involved_in	process	0.85
Autophagy	activates	pathway	0.80
Er Stress	activates	pathway	0.80
Cancer	inhibits	disease	0.75
Tumor	inhibits	disease	0.75
CANCER	inhibits	gene	0.70
Alzheimer's disease	activates	disease	0.70
autophagy pathway	participates_in	pathway	0.70
AUTOPHAGY	activates	gene	0.70
ATF4	activates	gene	0.70
CANCER	activates	gene	0.70
ADSL	activates	gene	0.70
BCL2	activates	gene	0.70
P62	activates	gene	0.70
NRF2	activates	gene	0.70
Ovarian Cancer	inhibits	disease	0.65
Cardiomyopathy	activates	disease	0.65
Lymphoma	inhibits	disease	0.65
Diabetes	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Carcinoma	activates	disease	0.65
Hepatocellular Carcinoma	activates	disease	0.65
Als	activates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Infection	implicated_in	disease	0.65
Ms	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Aging	implicated_in	disease	0.65
Cardiac	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Autoimmune	activates	disease	0.65
Senescence	associated_with	disease	0.65
Metabolic Syndrome	associated_with	disease	0.65
Cardiovascular	activates	disease	0.65
ALS	activates	disease	0.65
Dementia	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Diabetes	inhibits	disease	0.65
Cardiac	inhibits	disease	0.65
ALS	interacts_with	disease	0.65
Alzheimer	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65

Incoming (341)

Source	Relation	Type	Str
SB202190	activates	drug	0.95
Dolutegravir	activates	drug	0.92
DTG	activates	drug	0.90
ATG2A-G433A	upregulates	variant	0.85
GRP78	interacts_with	protein	0.85
ROS	interacts_with	gene	0.70
AGGF1	inhibits	gene	0.70
ALS	regulates	gene	0.60
DNA	regulates	gene	0.60
ERN1	activates	gene	0.60
NIX	regulates	gene	0.60
ATG	regulates	gene	0.60
NLR	regulates	gene	0.60
ATP	regulates	gene	0.60
CREB	activates	gene	0.60
ERBB2	activates	gene	0.60
IFN	activates	gene	0.60
DNM1L	activates	entity	0.60
LC3B	regulates	gene	0.60
IL23A	activates	gene	0.60
BCL2L11	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
NLRP3	interacts_with	gene	0.60
FMR1	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
EIF2S1	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
MIRO1	interacts_with	gene	0.60
PTEN	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
XBP1	activates	gene	0.60
ATF4	activates	gene	0.60
HSPA5	activates	gene	0.60
CK2	targets	gene	0.60
CLDN5	activates	gene	0.60
CXCL2	activates	gene	0.60
CK2	activates	gene	0.60
HIF	regulates	gene	0.60
IL12B	activates	gene	0.60
OCLN	activates	gene	0.60
IL6	activates	gene	0.60
DDIT3	activates	gene	0.60
GAIN	activates	gene	0.60
VDAC1	activates	gene	0.60
MCU	activates	gene	0.60
GPX4	inhibits	gene	0.60
KEAP1	activates	gene	0.60
BECN1	activates	gene	0.60
NOX4	interacts_with	gene	0.60
EIF2S1	activates	entity	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PERK in their description or question text

No additional research found