gene

SNCAIP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SNCAIP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

463Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

SNCAIP (Synphilin-1) is an alpha-synuclein interacting protein that plays a critical role in protein aggregation and degradation pathways in Parkinson's disease.

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🧬 Gene Info

Gene Symbol	SNCAIP
Full Name	Synphilin-1 (Alpha-Synuclein Interacting Protein)
Aliases	Synphilin-1
Chromosome	5q23.1
Function	is a 777-amino acid protein that plays critical roles in protein aggregation, degradation pathways, and neuronal survival.
Molecular Weight	91 kDa
Amino Acids	777 aa
Pathways	MAPK signaling, Reactive Oxygen Species, Wnt signaling, apoptosis, apoptosis pathway
UniProt ID	[O60341](https://www.uniprot.org/uniprot/O60341)
Ensembl ID	ENSG00000145341
GeneCards	SNCAIP
Human Protein Atlas	SNCAIP
Associated Diseases	AD, ALI, Als, Alzheimer, dementia
Interactions	ABCD3, Actin, ALS, ALZHEIMER, ALZHEIMER DISEASE, AMBRA1
KG Connections	463 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SNCAIP Gene

gene · 1842 words

→

SNCAIP Protein

protein · 666 words

→

Pathway Diagram

flowchart TD
    SNCAIP["SNCAIP
(Synphilin-1)"]
    SNCA["SNCA
(alpha-synuclein)"]
    PARKIN["PARKIN
(E3 ubiquitin ligase)"]
    PRKN["PRKN
(Parkin RBR E3
ubiquitin ligase)"]
    
    RB1CC1["RB1CC1
(FIP200/
autophagy initiator)"]
    LC3["LC3
(autophagosome
marker)"]
    FAM134B["FAM134B
(ER-phagy
receptor)"]
    
    MFN1["MFN1
(mitochondrial
fusion)"]
    MIRO1["MIRO1
(mitochondrial
transport)"]
    ERN1["ERN1
(ER stress
sensor)"]
    
    CTSD["CTSD
(cathepsin D/
lysosomal enzyme)"]
    BCL2L11["BCL2L11
(BIM/
pro-apoptotic)"]
    
    PD["Parkinson's
Disease"]
    AD["Alzheimer's
Disease"]
    ALS["Amyotrophic
Lateral Sclerosis"]
    FTD["Frontotemporal
Dementia"]
    
    ProteinAgg["Protein
Aggregation"]
    Autophagy["Autophagy
Dysfunction"]
    MitoStress["Mitochondrial
Dysfunction"]
    
    SNCAIP -->|"forms inclusions with"| SNCA
    SNCAIP -->|"interacts with"| PARKIN
    SNCAIP -->|"interacts with"| PRKN
    
    SNCAIP -->|"regulates"| RB1CC1
    RB1CC1 -->|"initiates"| LC3
    SNCAIP -->|"modulates"| FAM134B
    
    SNCAIP -->|"affects"| MFN1
    SNCAIP -->|"influences"| MIRO1
    SNCAIP -->|"responds to"| ERN1
    
    SNCAIP -->|"processed by"| CTSD
    SNCAIP -->|"activates"| BCL2L11
    
    SNCA -->|"contributes to"| ProteinAgg
    PARKIN -->|"dysfunction leads to"| Autophagy
    MFN1 -->|"dysfunction causes"| MitoStress
    
    ProteinAgg -->|"pathogenesis"| PD
    Autophagy -->|"impairment"| AD
    MitoStress -->|"contributes to"| ALS
    ProteinAgg -->|"involved in"| FTD
    
    style SNCAIP fill:#006494
    style PARKIN fill:#4a1a6b
    style PRKN fill:#4a1a6b
    style RB1CC1 fill:#1b5e20
    style LC3 fill:#1b5e20
    style CTSD fill:#1b5e20
    style PD fill:#ef5350
    style AD fill:#ef5350
    style ALS fill:#ef5350
    style FTD fill:#ef5350
    style ProteinAgg fill:#5d4400
    style Autophagy fill:#5d4400
    style MitoStress fill:#5d4400

Outgoing (181)

Target	Relation	Type	Str
ALS	interacts_with	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Ftd	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Wnt signaling	participates_in	pathway	0.60
Apoptosis	interacts_with	pathway	0.60
Mitophagy	interacts_with	pathway	0.60
Autophagy	interacts_with	pathway	0.60
Mapk	interacts_with	pathway	0.60
Cell Cycle	interacts_with	pathway	0.60
Mitophagy	therapeutic_target	pathway	0.60
Amyloid	interacts_with	pathway	0.60
Actin	interacts_with	protein	0.60
Α-Synuclein	interacts_with	protein	0.60
frontotemporal	associated_with	disease	0.60
AMYLOID	interacts_with	gene	0.60
PARKINSON'S DISEASE	interacts_with	gene	0.60
Alzheimer	associated_with	disease	0.60
ALS	associated_with	disease	0.60
SORL1	interacts_with	gene	0.60
LC3B	interacts_with	gene	0.60
RIP3	interacts_with	gene	0.60
DEMENTIA	interacts_with	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
ATP	interacts_with	gene	0.60
RAS	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
BIM	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
Endothelial	interacts_with	cell_type	0.60
dementia	associated_with	disease	0.60
Parkinson	associated_with	disease	0.60
BCL2L11	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
FMR1	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
FAM134B	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60

Incoming (282)

Source	Relation	Type	Str
LC3B	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
CTSD	activates	entity	0.60
RHOT1	interacts_with	gene	0.60
BNIP3	interacts_with	gene	0.60
DRP1	interacts_with	gene	0.60
SESN2	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
BCL2L13	interacts_with	gene	0.60
DDIT3	activates	entity	0.60
DISC1	activates	entity	0.60
EIF2S1	interacts_with	gene	0.60
MIRO1	interacts_with	gene	0.60
PTEN	interacts_with	gene	0.60
PERK	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
MAPK8	interacts_with	gene	0.60
EMD	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
DRP1	activates	entity	0.60
FUNDC1	interacts_with	gene	0.60
JNK	interacts_with	gene	0.60
RTN3	interacts_with	gene	0.60
RIPK3	interacts_with	gene	0.60
FIP200	interacts_with	gene	0.60
EIF2AK3	activates	entity	0.60
EIF2S1	activates	entity	0.60
EMD	activates	entity	0.60
EPAS1	activates	entity	0.60
ABCD3	activates	entity	0.60
AMBRA1	activates	entity	0.60
ATM	activates	entity	0.60
CDK5	interacts_with	gene	0.60
GSK3B	interacts_with	gene	0.60
MAPT	interacts_with	gene	0.60
NLR	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SNCAIP in their description or question text

No additional research found