gene

LGALS3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LGALS3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

953Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

LGALS3 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with AD, ALI, ALS. Connected to 455 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	LGALS3
Full Name	Lectin, Galactoside-Binding, Soluble, 3
Chromosome	14
Function	The LGALS3 gene encodes Lectin, Galactoside-Binding, Soluble, 3, a protein expressed in various brain regions including the cerebral cortex, hippocampus, basal ganglia, and cerebellum.
Primary Expression	activated microglia and plays complex roles in neuroinflammation - both promoting and resolving inflammatory responses
Pathways	Amyloid, Lipid Metabolism
UniProt ID	P17931
Ensembl ID	ENSG00000131981
OMIM	153619
GeneCards	LGALS3
Human Protein Atlas	LGALS3
Associated Diseases	AD, ALI, Als, Alzheimer, Amyotrophic Lateral Sclerosis
Known Drugs/Compounds	rapamycin
Interactions	ABCD3, ACTB, ALS, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE
SciDEX Hypotheses	Galectin-3 deletion attenuates NLRP3 inflammasome
KG Connections	945 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: LGALS3 — AlphaFold P17931 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

LGALS3 Gene

gene · 953 words

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Pathway Diagram

graph TD
    LGALS3["LGALS3
(Galectin-3)"]:::central
    
    LGALS3 -->|"interacts_with"| Dementia["Dementia"]
    LGALS3 -->|"interacts_with"| Cardiovascular["Cardiovascular
Disease"]
    LGALS3 -->|"interacts_with"| Als["ALS"]
    LGALS3 -->|"interacts_with"| Alzheimer["Alzheimer's
Disease"]
    LGALS3 -->|"interacts_with"| Parkinson["Parkinson's
Disease"]
    LGALS3 -->|"interacts_with"| Ms["Multiple
Sclerosis"]
    LGALS3 -->|"associated_with"| AmyotrophicLateralSclerosis["Amyotrophic
Lateral Sclerosis"]
    LGALS3 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    LGALS3 -->|"associated_with"| Ataxia["Ataxia"]
    LGALS3 -->|"associated_with"| Huntington["Huntington's
Disease"]
    LGALS3 -->|"therapeutic_target"| AlsTarget["ALS
Treatment"]
    LGALS3 -->|"therapeutic_target"| MsTarget["MS
Treatment"]
    
    classDef central fill:#FF6B6B,stroke:#C92A2A,stroke-width:3px,color:#e0e0e0,font-size:14px
    classDef disease fill:#4ECDC4,stroke:#0A8A80,stroke-width:2px,color:#e0e0e0
    classDef process fill:#FFE66D,stroke:#D4A600,stroke-width:2px,color:#e0e0e0
    classDef target fill:#95E1D3,stroke:#38A169,stroke-width:2px,color:#e0e0e0
    
    class Dementia,Cardiovascular,Als,Alzheimer,Parkinson,Ms,AmyotrophicLateralSclerosis,Ataxia,Huntington disease
    class Neurodegeneration process
    class AlsTarget,MsTarget target

Outgoing (558)

Target	Relation	Type	Str
ds-f2c28aed24a7	provides_data_for	dataset	1.00
lysosomal damage	associated_with	process	0.95
neuroinflammation	drives	process	0.90
microglial activation	drives	process	0.90
amyloid-beta plaque clearance	promotes	process	0.88
Amyloid-Beta Plaque Clearance	mediates	process	0.87
TREM2	interacts_with	protein	0.85
Huntington's Disease	implicated_in	disease	0.85
TLR4	interacts_with	protein	0.84
oxidative stress response	participates_in	pathway	0.80
neural stem cells	activates	cell_type	0.80
Psoriasis	associated_with	disease	0.80
Neurodegeneration	activates	disease	0.75
Als	associated_with	disease	0.75
ciliary signaling	regulates	pathway	0.75
dopaminergic signaling	regulates	pathway	0.75
neural stem cells	interacts_with	cell_type	0.70
PPP3CB	associated_with	protein	0.70
tau_vesicles	targets	cellular_component	0.70
GENES	activates	gene	0.70
autophagy	regulates	biological_process	0.70
NEURODEGENERATION	activates	gene	0.70
Parkinson's disease	activates	disease	0.70
MCOLN1	interacts_with	gene	0.70
ALS	activates	disease	0.70
TFEB	interacts_with	gene	0.70
autophagy pathway	participates_in	pathway	0.70
Hepatitis	associated_with	disease	0.65
Ms	expressed_in	disease	0.65
Fibrosis	associated_with	disease	0.65
Leukemia	associated_with	disease	0.65
Aging	therapeutic_target	disease	0.65
Glioblastoma	expressed_in	disease	0.65
Stroke	activates	disease	0.65
Cancer	expressed_in	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Multiple Sclerosis	regulates	disease	0.65
Tumor	expressed_in	disease	0.65
Ms	regulates	disease	0.65
Als	expressed_in	disease	0.65
Ischemia	activates	disease	0.65
Carcinoma	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Obesity	associated_with	disease	0.65
Lymphoma	associated_with	disease	0.65
Leukemia	expressed_in	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Atherosclerosis	expressed_in	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65

Incoming (395)

Source	Relation	Type	Str
ds-f2c28aed24a7	data_in	dataset	1.00
berbamine hydrochloride	inhibits	drug	0.95
APOE4	regulates	gene	0.85
CTSB	interacts_with	gene	0.70
DNA	activates	gene	0.70
ATG	activates	gene	0.70
HSPB8	associated_with	gene	0.60
P62	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
FOXO3	inhibits	gene	0.60
TCF7L2	inhibits	gene	0.60
RAGE	activates	gene	0.60
TNF	therapeutic_target	gene	0.60
EGFR	therapeutic_target	gene	0.60
GAPDH	therapeutic_target	gene	0.60
PPP3CB	interacts_with	gene	0.60
TFEB	activates	gene	0.60
MTOR	activates	gene	0.60
CAPN1	therapeutic_target	gene	0.60
SOD1	associated_with	gene	0.60
DISC1	activates	entity	0.60
FUNDC1	interacts_with	gene	0.60
FIP200	interacts_with	gene	0.60
CALCINEURIN	activates	gene	0.60
TDP-43	associated_with	gene	0.60
TTR	therapeutic_target	gene	0.60
BCL2	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
DEMENTIA	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
ASTROCYTE	regulates	gene	0.60
APOE3	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
APP/PS1	activates	gene	0.60
MICROGLIA	regulates	gene	0.60
ATP	activates	gene	0.60
BIM	activates	gene	0.60
HIF	activates	gene	0.60
HIF1	activates	gene	0.60
CD44	expressed_in	gene	0.60
SESN3	expressed_in	gene	0.60
GPNMB	expressed_in	gene	0.60
GAIN	expressed_in	gene	0.60
CSF1R	expressed_in	gene	0.60
LC3B	interacts_with	gene	0.60
APOE4	inhibits	gene	0.60
ACTB	activates	gene	0.60
ACTB	interacts_with	gene	0.60
ERK	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Galectin-3 deletion attenuates NLRP3 inflammasome activation	0.650	neuroscience	Lysosomal dysfunction and cathepsin leak

Mentioning Analyses (1)

Scientific analyses that reference this entity

Do tau-containing vesicles exhibit unique surface glycosylation patterns that di

neurodegeneration | 2026-04-09 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Do tau-containing vesicles exhibit unique surface glycosylation patterns that di

closed · Rounds: 4 · Score: 0.95 · 2026-04-10

Related Research

Hypotheses and analyses mentioning LGALS3 in their description or question text

No additional research found