gene

DDIT3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DDIT3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

940Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

DDIT3 (CHOP) is a pro-apoptotic transcription factor mediating ER stress responses; implicated in AD, PD, ALS, and other neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	DDIT3
Chromosome	12q24.1
Protein Type	Gene
Function	is an important component in the neurobiology of neurodegenerative diseases.
Amino Acids	169 aa
Pathways	Akt, Wnt
UniProt ID	P35638
NCBI Gene ID	1649
Ensembl ID	ENSG00000100994
GeneCards	DDIT3
Human Protein Atlas	DDIT3
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	rapamycin
Interactions	ABCD3, Actin, AKT, AKT1, AKT1S1, ALS
KG Connections	940 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DDIT3 — AlphaFold P35638 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DDIT3 Gene

gene · 899 words

→

CHOP Protein (DDIT3)

protein · 1489 words

→

Pathway Diagram

graph TD
    DDIT3["DDIT3"] -->|"interacts"| Dementia["Dementia"]
    DDIT3["DDIT3"] -->|"interacts"| Cardiovascular["Cardiovascular"]
    DDIT3["DDIT3"] -->|"interacts"| Als["Als"]
    DDIT3["DDIT3"] -->|"interacts"| Alzheimer["Alzheimer"]
    DDIT3["DDIT3"] -->|"interacts"| Parkinson["Parkinson"]
    DDIT3["DDIT3"] -->|"interacts"| Ms["Ms"]
    CAT["CAT"] -->|"interacts"| DDIT3["DDIT3"]
    OPTN["OPTN"] -->|"interacts"| DDIT3["DDIT3"]
    DNM1L["DNM1L"] -->|"interacts"| DDIT3["DDIT3"]
    CANX["CANX"] -->|"interacts"| DDIT3["DDIT3"]
    style DDIT3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (634)

Target	Relation	Type	Str
Endoplasmic Reticulum Stress	participates_in	biological_process	0.80
PUMA	upregulates	gene	0.80
ATF4	upregulates	gene	0.80
HSPA5	upregulates	gene	0.80
Als	activates	disease	0.75
Tumor	activates	disease	0.75
MAPK signaling	participates_in	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
neural stem cells	activates	cell_type	0.70
necroptosis	participates_in	pathway	0.70
oxidative stress response	participates_in	pathway	0.70
ROS	regulates	gene	0.70
DNA	regulates	gene	0.70
EIF2AK3	regulates	gene	0.70
STING1	regulates	gene	0.70
NLR	regulates	gene	0.70
OPTN	regulates	gene	0.70
neural stem cells	regulates	cell_type	0.70
NLR	activates	gene	0.70
LC3	regulates	gene	0.70
RB1	regulates	gene	0.70
FIP200	regulates	gene	0.70
ERN1	regulates	gene	0.70
NBR1	regulates	gene	0.70
RB1CC1	regulates	gene	0.70
Er Stress	activates	pathway	0.70
JNK	regulates	gene	0.70
SQSTM1	regulates	gene	0.70
DNA	activates	gene	0.70
Frontotemporal Dementia	interacts_with	disease	0.65
Ftd	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Als	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Fibrosis	regulates	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Fibrosis	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
ALS	activates	disease	0.65
Ms	associated_with	disease	0.65
Cancer	therapeutic_target	disease	0.65
Fibrosis	therapeutic_target	disease	0.65

Incoming (306)

Source	Relation	Type	Str
DTG	upregulates	drug	0.85
ATF4	activates	gene	0.70
CAT	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
SNCAIP	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
BNIP3	interacts_with	gene	0.60
MUL1	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
FMR1	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
FAM134B	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
EPAS1	interacts_with	gene	0.60
MIRO1	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
BCL2L11	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60
EIF2S1	interacts_with	gene	0.60
RIPK3	interacts_with	gene	0.60
DRP1	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
PTEN	interacts_with	gene	0.60
CASP3	interacts_with	gene	0.60
AKT1	interacts_with	gene	0.60
CGAS	interacts_with	gene	0.60
CFTR	interacts_with	gene	0.60
RPS6KB1	interacts_with	gene	0.60
GRB2	interacts_with	gene	0.60
RHEB	interacts_with	gene	0.60
EIF2A	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
ATG16L1	interacts_with	gene	0.60
GABARAP	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
ATF4-DDIT3 stress signaling indirectly represses MAPT transc	0.624	neurodegeneration	Which specific transcription factors med

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DDIT3 in their description or question text

No additional research found