gene

DDIT3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DDIT3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

945Connections

1Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

3Debates

Summary

DDIT3 (CHOP) is a pro-apoptotic transcription factor mediating ER stress responses; implicated in AD, PD, ALS, and other neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	DDIT3
Chromosome	12q24.1
Protein Type	Gene
Function	is an important component in the neurobiology of neurodegenerative diseases.
Amino Acids	169 aa
Pathways	Akt, Wnt
UniProt ID	P35638
NCBI Gene ID	1649
Ensembl ID	ENSG00000100994
GeneCards	DDIT3
Human Protein Atlas	DDIT3
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	rapamycin
Interactions	ABCD3, Actin, AKT, AKT1, AKT1S1, ALS
KG Connections	944 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DDIT3 — AlphaFold P35638 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DDIT3 Gene

gene · 899 words

→

CHOP Protein (DDIT3)

protein · 1489 words

→

Pathway Diagram

graph TD
    DDIT3["DDIT3"] -->|"interacts"| Dementia["Dementia"]
    DDIT3["DDIT3"] -->|"interacts"| Cardiovascular["Cardiovascular"]
    DDIT3["DDIT3"] -->|"interacts"| Als["Als"]
    DDIT3["DDIT3"] -->|"interacts"| Alzheimer["Alzheimer"]
    DDIT3["DDIT3"] -->|"interacts"| Parkinson["Parkinson"]
    DDIT3["DDIT3"] -->|"interacts"| Ms["Ms"]
    CAT["CAT"] -->|"interacts"| DDIT3["DDIT3"]
    OPTN["OPTN"] -->|"interacts"| DDIT3["DDIT3"]
    DNM1L["DNM1L"] -->|"interacts"| DDIT3["DDIT3"]
    CANX["CANX"] -->|"interacts"| DDIT3["DDIT3"]
    style DDIT3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (636)

Target	Relation	Type	Str
DDIT3	encodes	protein	0.00
Endoplasmic Reticulum Stress	participates_in	process	0.80
PUMA	upregulates	gene	0.80
ATF4	upregulates	gene	0.80
HSPA5	upregulates	gene	0.80
Tumor	activates	disease	0.75
Als	activates	disease	0.75
autophagy pathway	participates_in	pathway	0.70
oxidative stress response	participates_in	pathway	0.70
MAPK signaling	participates_in	pathway	0.70
JNK	regulates	gene	0.70
LC3	regulates	gene	0.70
SQSTM1	regulates	gene	0.70
STING1	regulates	gene	0.70
necroptosis	participates_in	pathway	0.70
NBR1	regulates	gene	0.70
EIF2AK3	regulates	gene	0.70
OPTN	regulates	gene	0.70
ERN1	regulates	gene	0.70
FIP200	regulates	gene	0.70
RB1	regulates	gene	0.70
RB1CC1	regulates	gene	0.70
Er Stress	activates	pathway	0.70
ER stress	activates	mechanism	0.70
NLR	regulates	gene	0.70
NLR	activates	gene	0.70
DNA	regulates	gene	0.70
ROS	regulates	gene	0.70
neural stem cells	regulates	cell_type	0.70
DNA	activates	gene	0.70
neural stem cells	activates	cell_type	0.70
MAPT	inhibits	gene	0.70
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Glioma	activates	disease	0.65
ALS	interacts_with	disease	0.65
Fibrosis	interacts_with	disease	0.65
Fibrosis	regulates	disease	0.65
Cancer	interacts_with	disease	0.65
Als	regulates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	inhibits	disease	0.65
Carcinoma	inhibits	disease	0.65
Cancer	activates	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Parkinson	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Heart Failure	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Dementia	interacts_with	disease	0.65

Incoming (309)

Source	Relation	Type	Str
DDIT3	encodes	gene	0.00
H5	inhibits	hypothesis	0.00
DTG	upregulates	drug	0.85
ATF4	activates	gene	0.70
proteostatic_stress	activates	process	0.70
HSPA5	activates	gene	0.60
CXCL2	activates	gene	0.60
IL23A	activates	gene	0.60
PERK	activates	gene	0.60
IL12B	activates	gene	0.60
OCLN	activates	gene	0.60
IL6	activates	gene	0.60
ATM	activates	entity	0.60
BCL2L11	activates	entity	0.60
ABCD3	activates	entity	0.60
BCL2L13	activates	entity	0.60
PI3K	interacts_with	gene	0.60
BNIP3	activates	entity	0.60
OCLN	therapeutic_target	gene	0.60
HSP70	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
MLST8	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
TFE3	interacts_with	gene	0.60
CLDN5	therapeutic_target	gene	0.60
BECN1	activates	entity	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
ROS	interacts_with	gene	0.60
LYSOSOME	interacts_with	gene	0.60
MTORC1	interacts_with	gene	0.60
RAS	interacts_with	gene	0.60
ALS	activates	entity	0.60
AMPK	activates	entity	0.60
CANCER	phosphorylates	entity	0.60
CYTOKINES	therapeutic_target	gene	0.60
DNA	activates	gene	0.60
rapamycin	targets	drug	0.60
ALS	regulates	gene	0.60
AMPK	regulates	gene	0.60
ATG	regulates	gene	0.60
ATP	regulates	gene	0.60
HIF1	interacts_with	gene	0.60
PARKINSON	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60