gene

SARS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SARS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

151Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

SARS1

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🧬 Gene Info

Gene Symbol	SARS
Aliases	Seryl-tRNA Synthetase 1
Function	SARS1 is a human gene whose product encodes seryl-tRNA synthetase 1 (SerRS), an enzyme essential for protein synthesis
Primary Expression	blood-brain barrier
Amino Acids	514 aa
Pathways	Mitochondrial Function, Apoptosis, Inflammasome, Immune Response, autophagy pathway
GeneCards	SARS
Human Protein Atlas	SARS
Associated Diseases	Aging, ALS, Alzheimer, Covid, disease, Infection
Known Drugs/Compounds	metformin, quercetin, rapamycin
Interactions	ACE2, AND, APOE, APOE4, APOPTOSIS, ATF4
KG Connections	151 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

SARS1

gene · 833 words

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Pathway Diagram

graph TD
    SARS["SARS"]
    FCGRT["FCGRT"]
    SARS -->|"interacts with"| FCGRT
    Infection["Infection"]
    SARS -->|"regulates"| Infection
    FCGRT["FCGRT"]
    SARS -->|"regulates"| FCGRT
    Infection["Infection"]
    SARS -->|"activates"| Infection
    FCGRT["FCGRT"]
    SARS -->|"activates"| FCGRT
    Infection["Infection"]
    SARS -->|"protects against"| Infection
    LYSOSOME["LYSOSOME"]
    SARS -->|"activates"| LYSOSOME
    ATG8["ATG8"]
    SARS -->|"activates"| ATG8
    RAPAMYCIN["RAPAMYCIN"]
    SARS -->|"activates"| RAPAMYCIN
    Infection["Infection"]
    SARS -->|"associated with"| Infection
    B_CELLS["B CELLS"]
    SARS -->|"regulates"| B_CELLS
    disease["disease"]
    SARS -->|"associated with"| disease
    Covid["Covid"]
    SARS -->|"associated with"| Covid
    Infection["Infection"]
    SARS -->|"causes"| Infection
    Covid["Covid"]
    SARS -->|"causes"| Covid
    Proteins["Proteins"]
    SARS -->|"associated with"| Proteins
    Covid["Covid"]
    SARS -->|"activates"| Covid
    disease["disease"]
    SARS -->|"causes"| disease
    Infection["Infection"]
    SARS -->|"interacts with"| Infection
    Infection["Infection"]
    SARS -->|"inhibits"| Infection
    Genes["Genes"]
    SARS -->|"associated with"| Genes
    CELL_DEATH["CELL DEATH"]
    SARS -->|"activates"| CELL_DEATH
    Proteins["Proteins"]
    SARS -->|"activates"| Proteins
    MAPT["MAPT"]
    MAPT -->|"activates"| SARS
    EIF2A["EIF2A"]
    EIF2A -->|"activates"| SARS
    ATF4["ATF4"]
    ATF4 -->|"activates"| SARS
    Autophagy["Autophagy"]
    Autophagy -->|"activates"| SARS
    G3BP1["G3BP1"]
    G3BP1 -->|"activates"| SARS
    GABA["GABA"]
    GABA -->|"activates"| SARS
    mTOR["mTOR"]
    mTOR -->|"activates"| SARS

Outgoing (95)

Target	Relation	Type	Str
pericytes	expressed_in	cell_type	0.70
macrophages	expressed_in	cell_type	0.70
ALS	interacts_with	disease	0.65
Cardiovascular	activates	disease	0.65
Obesity	activates	disease	0.65
Diabetes	activates	disease	0.65
ALS	activates	disease	0.65
Hypertension	activates	disease	0.65
Aging	associated_with	disease	0.65
Inflammation	contributes_to	disease	0.65
Stroke	contributes_to	disease	0.65
Anxiety	contributes_to	disease	0.65
Traumatic Brain Injury	contributes_to	disease	0.65
ALS	associated_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Neurodegeneration	contributes_to	disease	0.65
Neuroinflammation	contributes_to	disease	0.65
Als	interacts_with	disease	0.65
Alzheimer	associated_with	disease	0.65
NLRP3	interacts_with	gene	0.60
Inflammasome	interacts_with	pathway	0.60
Immune Response	interacts_with	pathway	0.60
ACE2	interacts_with	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
APOE4	interacts_with	gene	0.60
epigenetic regulation	participates_in	pathway	0.60
complement cascade	participates_in	pathway	0.60
AND	activates	gene	0.60
RNA	protects_against	gene	0.60
AND	associated_with	gene	0.60
STAT1	activates	gene	0.60
TLR4	activates	gene	0.60
IFN	activates	gene	0.60
STAT3	activates	gene	0.60
AND	causes	gene	0.60
PROINFLAMMATORY CYTOKINES	activates	gene	0.60
CYTOKINES	activates	gene	0.60
AND	inhibits	gene	0.60
endothelial cells	expressed_in	cell_type	0.60
stem cells	expressed_in	cell_type	0.60
neuroinflammation	activates	disease	0.60
T cells	expressed_in	cell_type	0.60
microglia	expressed_in	cell_type	0.60
blood-brain barrier	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.60
pyroptosis	participates_in	pathway	0.60
blood-brain barrier	expressed_in	brain_region	0.60
traumatic brain injury	activates	disease	0.60
neuroinflammation	regulates	disease	0.60
neuroinflammation	causes	disease	0.60

Incoming (56)

Source	Relation	Type	Str
EGFR	activates	gene	0.60
APOE	interacts_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
NRF2	associated_with	gene	0.60
BIN1	interacts_with	gene	0.60
MAPT	interacts_with	gene	0.60
BRAIN INJURY	contributes_to	gene	0.60
ANXIETY	contributes_to	gene	0.60
APOPTOSIS	activates	gene	0.60
ATP	causes	gene	0.60
NEURODEGENERATION	activates	gene	0.60
ACE2	regulates	gene	0.60
ATP	activates	gene	0.60
ROS	activates	gene	0.60
IFN	inhibits	gene	0.60
quercetin	targets	drug	0.60
ACE2	inhibits	gene	0.60
ACE2	associated_with	gene	0.60
IFN	activates	gene	0.60
RNA	associated_with	gene	0.60
DNA	activates	gene	0.60
DNA	inhibits	gene	0.60
NLRP3	regulates	gene	0.60
NLRP3	associated_with	gene	0.60
P2X7	associated_with	gene	0.60
NLRP3	interacts_with	gene	0.60
KRAS	inhibits	gene	0.60
ACE2	interacts_with	gene	0.60
FCGRT	interacts_with	gene	0.60
FCGRT	regulates	gene	0.60
ACE2	activates	gene	0.60
FCGRT	activates	gene	0.60
ATG	activates	gene	0.60
MTOR	activates	gene	0.60
RNA	activates	gene	0.60
rapamycin	targets	drug	0.60
NUFIP2	activates	gene	0.60
NLRP3	activates	gene	0.60
metformin	targets	drug	0.60
GABA	activates	gene	0.50
mTOR	activates	entity	0.50
FMR1	activates	gene	0.50
EIF2Α	activates	protein	0.50
GABARAP	activates	protein	0.50
MAPT	activates	gene	0.50
STAT3	activates	gene	0.50
Neurodegeneration	activates	disease	0.50
MITOCHONDRIA	activates	cell_type	0.50
MITOCHONDRIA	associated_with	cell_type	0.50
TIA1	activates	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SARS in their description or question text

No additional research found