protein

PARL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PARL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

520Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

PARL is a protein involved in neurodegeneration research. Key relationships include: interacts with, implicated in, activates. Associated with AD, ALI, Als. Connected to 190 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	PARL
Chromosome	3q27.1
Protein Type	Protein
Function	OPA1 processing: Cleaves OPA1 (optic atrophy 1) to regulate mitochondrial fusion
Subcellular Localization	** Inner mitochondrial membrane
Molecular Weight	42 kDa
Amino Acids	379 aa
Pathways	Autophagy
UniProt ID	Search UniProt
GeneCards	PARL
Human Protein Atlas	PARL
Associated Diseases	AD, ALI, Als, Alzheimer, Cardiac
Interactions	ABCD3, Actin, AIFM1, ALS, ALZHEIMER, ALZHEIMER DISEASE
KG Connections	520 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: PARL — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PARL Protein

protein · 513 words

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Pathway Diagram

graph TD
    PARL["PARL"]
    PARL -->|"interacts"| Alzheimer["Alzheimer"]
    PARL -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    PARL -->|"interacts"| Dementia["Dementia"]
    PARL -->|"interacts"| Cardiovascular["Cardiovascular"]
    PARL -->|"interacts"| Parkinson["Parkinson"]
    PARL -->|"interacts"| EIF2S1["EIF2S1"]
    PARL -->|"interacts"| NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    PARL -->|"interacts"| ALS["ALS"]
    PARL -->|"interacts"| CALCOCO2["CALCOCO2"]
    PARL -->|"interacts"| MIRO1["MIRO1"]
    BCL2L11["BCL2L11"] -->|"interacts"| PARL
    DNA["DNA"] -->|"interacts"| PARL
    NIX["NIX"] -->|"interacts"| PARL
    HIF1["HIF1"] -->|"interacts"| PARL
    RB1["RB1"] -->|"interacts"| PARL
    NLRP3["NLRP3"] -->|"interacts"| PARL
    PARKINSON["PARKINSON"] -->|"interacts"| PARL
    FMR1["FMR1"] -->|"interacts"| PARL
    RB1CC1["RB1CC1"] -->|"interacts"| PARL

Outgoing (244)

Target	Relation	Type	Str
PINK1	associated_with	protein	0.90
Cardiac	implicated_in	disease	0.65
Heart Failure	implicated_in	disease	0.65
Als	associated_with	disease	0.65
Als	interacts_with	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Cardiac	activates	disease	0.65
Dementia	interacts_with	disease	0.65
Cancer	therapeutic_target	disease	0.65
Alzheimer	activates	disease	0.65
Parkinson	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
PRKN	activates	gene	0.60
FUNDC1	associated_with	gene	0.60
DRP1	regulates	gene	0.60
STX17	regulates	gene	0.60
OPTN	regulates	gene	0.60
USP30	implicated_in	gene	0.60
ATG	interacts_with	gene	0.60
TOMM20	interacts_with	gene	0.60
RTN3	activates	entity	0.60
RIPK3	activates	entity	0.60
PIK3C3	activates	gene	0.60
SESN2	activates	entity	0.60
SNCA	activates	entity	0.60
SNCAIP	activates	entity	0.60
SQSTM1	activates	entity	0.60
STING1	activates	entity	0.60
TAX1BP1	activates	entity	0.60
UBIQUITIN	activates	entity	0.60
PHB2	interacts_with	gene	0.60
PERK	activates	entity	0.60
PARKIN	associated_with	gene	0.60
CPT2	implicated_in	gene	0.60
RHOT1	activates	entity	0.60
frontotemporal	associated_with	disease	0.60
RB1CC1	activates	entity	0.60
TOMM70	interacts_with	gene	0.60
ALZHEIMER DISEASE	interacts_with	gene	0.60
PHB2	regulates	gene	0.60
TUBB	activates	gene	0.60
cancer	activates	disease	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
ALS	interacts_with	gene	0.60
ATP	interacts_with	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
PGAM5	interacts_with	gene	0.60
RETREG1	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60

Incoming (276)

Source	Relation	Type	Str
DISC1	activates	entity	0.60
DNM1L	activates	entity	0.60
DRP1	activates	entity	0.60
BCL2L11	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
FMR1	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
EPAS1	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
MAPK8	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
CAT	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
EMD	interacts_with	gene	0.60
MIRO1	interacts_with	gene	0.60
PTEN	interacts_with	gene	0.60
SESN2	interacts_with	gene	0.60
FUNDC1	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
JNK	interacts_with	gene	0.60
RTN3	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
DRP1	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
RIPK3	interacts_with	gene	0.60
RHOT1	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
MUL1	interacts_with	gene	0.60
HIF1A	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
FIP200	interacts_with	gene	0.60
PERK	interacts_with	gene	0.60
SNCAIP	interacts_with	gene	0.60
EIF2S1	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60
CHOP	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60
DDIT3	activates	entity	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PARL in their description or question text

No additional research found