gene

FIP200

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FIP200: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1093Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

FIP200 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with AD, ALI, Aging. Connected to 512 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	FIP200
Chromosome	6q24.2
Protein Type	Scaffold Protein
Function	is a 200 kDa scaffold protein that plays essential roles in autophagy initiation, cell adhesion, migration, and neuronal survival.
Molecular Weight	200 kDa
Amino Acids	664 aa
Pathways	Akt, Apoptosis, Autophagy, Wnt, autophagy
Ensembl ID	ENSG00000048991
GeneCards	FIP200
Human Protein Atlas	FIP200
Mitochondrial quality control	Removing damaged mitochondria through mitophagy
Protein aggregate clearance	Degrading misfolded proteins and aggregates
Synaptic maintenance	Regulating synaptic vesicle recycling and neurotransmitter release
Neuronal survival	Preventing apoptosis under cellular stress
Associated Diseases	AD, ALI, Als, Alzheimer, Cancer
Known Drugs/Compounds	rapamycin
Interactions	ABCD3, ACAT1, Actin, AGING, AKT1, AKT1S1
KG Connections	1093 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

fip200

gene · 2347 words

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Pathway Diagram

graph TD
    FIP200["FIP200"] -->|"interacts"| LC3["LC3"]
    FIP200["FIP200"] -->|"interacts"| Dementia["Dementia"]
    FIP200["FIP200"] -->|"interacts"| Cardiovascular["Cardiovascular"]
    FIP200["FIP200"] -->|"interacts"| Als["Als"]
    FIP200["FIP200"] -->|"interacts"| Alzheimer["Alzheimer"]
    FIP200["FIP200"] -->|"interacts"| Parkinson["Parkinson"]
    NDP52["NDP52"] -->|"interacts"| FIP200["FIP200"]
    CAT["CAT"] -->|"interacts"| FIP200["FIP200"]
    OPTN["OPTN"] -->|"interacts"| FIP200["FIP200"]
    DNM1L["DNM1L"] -->|"interacts"| FIP200["FIP200"]
    style FIP200 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (685)

Target	Relation	Type	Str
ULK1/2 COMPLEX	associated_with	protein	0.90
TBK1	inhibits	protein	0.90
neurogenesis	regulates	pathway	0.90
p62	inhibits	protein	0.90
neural stem cells	regulates	cell_type	0.90
autophagy	regulates	pathway	0.90
Autophagy	interacts_with	pathway	0.90
ULK1	interacts_with	protein	0.84
RB1CC1	regulates	gene	0.80
OPTN	regulates	gene	0.80
SQSTM1	regulates	gene	0.80
autophagy pathway	participates_in	pathway	0.80
RB1	regulates	gene	0.80
NBR1	regulates	gene	0.80
neural stem cells	activates	cell_type	0.80
CXCL10	inhibits	protein	0.80
CCL5	inhibits	protein	0.80
Mitophagy	interacts_with	pathway	0.80
TBK1	interacts_with	gene	0.80
Neurodegeneration	interacts_with	disease	0.75
Als	activates	disease	0.75
Als	interacts_with	disease	0.75
Tumor	associated_with	disease	0.75
Apoptosis	associated_with	pathway	0.70
Autophagy	associated_with	pathway	0.70
Autophagy	inhibits	pathway	0.70
AUTOPHAGY	inhibits	gene	0.70
OPTN	interacts_with	gene	0.70
ATG7	associated_with	gene	0.70
AUTOPHAGY	associated_with	gene	0.70
P62	interacts_with	gene	0.70
LC3	interacts_with	protein	0.70
NLR	activates	gene	0.70
RB1	associated_with	gene	0.70
ROS	activates	gene	0.70
PIK3C3	regulates	gene	0.70
AMPK signaling	participates_in	pathway	0.70
apoptosis pathway	participates_in	pathway	0.70
NDP52	regulates	gene	0.70
ATG16L1	associated_with	gene	0.70
TFEB	regulates	gene	0.70
MTOR	regulates	gene	0.70
TAX1BP1	interacts_with	gene	0.70
MAPK signaling	participates_in	pathway	0.70
necroptosis	participates_in	pathway	0.70
Parkinson's disease	regulates	disease	0.70
STING1	regulates	gene	0.70
JNK	regulates	gene	0.70
NLR	regulates	gene	0.70
Parkinson's disease	activates	disease	0.70

Incoming (408)

Source	Relation	Type	Str
ULK1	associated_with	gene	0.90
TAX1BP1	interacts_with	gene	0.90
AUTOPHAGY	interacts_with	gene	0.90
P62	associated_with	protein	0.85
TAX1BP1	associated_with	protein	0.85
NDP52	associated_with	protein	0.85
NDP52	interacts_with	protein	0.84
ATG	component_of	gene	0.80
TBK1	modulates	protein	0.80
MITOPHAGY	interacts_with	gene	0.80
PINK1	interacts_with	gene	0.80
ATG5	associated_with	gene	0.70
ERN1	regulates	gene	0.70
CALCOCO2	regulates	gene	0.70
NEURODEGENERATION	interacts_with	gene	0.70
BECN1	regulates	gene	0.70
EIF2AK3	regulates	gene	0.70
DDIT3	regulates	gene	0.70
RB1CC1	encodes	gene	0.70
miR-224-3p	inhibits	gene	0.70
PTEN	interacts_with	gene	0.70
PARKIN	interacts_with	gene	0.70
rapamycin	targets	drug	0.70
ATG	interacts_with	gene	0.70
DNA	regulates	gene	0.70
ATG	regulates	gene	0.70
DNA	activates	gene	0.70
ATG	activates	gene	0.70
AMPK	regulates	gene	0.70
BECN1	associated_with	gene	0.70
AGING	activates	gene	0.60
MICROGLIA	activates	gene	0.60
LC3B	expressed_in	gene	0.60
LC3B	activates	gene	0.60
DNA	interacts_with	gene	0.60
NIX	interacts_with	gene	0.60
PARKINSON	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
ALS	interacts_with	gene	0.60
ATG14L	activates	gene	0.60
LYSOSOME	activates	gene	0.60
AND	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
MTOR	associated_with	gene	0.60
BECN1	inhibits	gene	0.60
CANCER	therapeutic_target	gene	0.60
LAMP2A	associated_with	gene	0.60
KAT2A	associated_with	gene	0.60
TP53	associated_with	gene	0.60
PARL	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FIP200 in their description or question text

No additional research found