gene

CALCOCO2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CALCOCO2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1121Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

Page for CALCOCO2 — Calcium Binding and Coiled-Coil Domain 2

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🧬 Gene Info

Gene Symbol	CALCOCO2
Full Name	Calcium Binding and Coiled-Coil Domain 2
Chromosome	17q25.1
Protein Type	Receptor
Function	Xenophagy: Recognition and elimination of intracellular pathogens including bacteria, viruses, and parasites
Molecular Weight	52 kDa
Amino Acids	446 aa
Pathways	Akt, Autophagy, Mapk, Mitophagy, Mtor
UniProt ID	[Q9BQB6](https://www.uniprot.org/uniprot/Q9BQB6)
Ensembl ID	ENSG00000136436
OMIM	604551
GeneCards	CALCOCO2
Human Protein Atlas	CALCOCO2
Associated Diseases	Als, Alzheimer, Alzheimer's disease, Cardiac, Crohn's disease
Known Drugs/Compounds	dimethyl fumarate, rapamycin
Interactions	ABCD3, ABP, ACAT1, ACTB, Actin, AIFM1
KG Connections	1121 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CALCOCO2 — Calcium Binding and Coiled-Coil Domain 2

gene · 606 words

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Pathway Diagram

graph TD
    CALCOCO2["CALCOCO2"] -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    CALCOCO2["CALCOCO2"] -->|"interacts"| Dementia["Dementia"]
    CALCOCO2["CALCOCO2"] -->|"interacts"| Als["Als"]
    CALCOCO2["CALCOCO2"] -->|"interacts"| Cardiovascular["Cardiovascular"]
    CALCOCO2["CALCOCO2"] -->|"interacts"| Alzheimer["Alzheimer"]
    CALCOCO2["CALCOCO2"] -->|"interacts"| Parkinson["Parkinson"]
    PEDV_N_protein["PEDV_N_protein"] -->|"interacts"| CALCOCO2["CALCOCO2"]
    ACTB["ACTB"] -->|"interacts"| CALCOCO2["CALCOCO2"]
    OPTN["OPTN"] -->|"interacts"| CALCOCO2["CALCOCO2"]
    ULK1["ULK1"] -->|"interacts"| CALCOCO2["CALCOCO2"]
    style CALCOCO2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (754)

Target	Relation	Type	Str
AUTOPHAGY	mediates	entity	0.95
LC3B	interacts_with	protein	0.90
autophagy pathway	participates_in	pathway	0.90
ubiquitin-proteasome	participates_in	pathway	0.90
Stress Granule Elimination	mediates	process	0.90
autophagy	participates_in	pathway	0.90
selective autophagy	participates_in	pathway	0.90
Autophagy	associated_with	process	0.85
PEDV N	binds	protein	0.85
Autophagosome	involved_in	cell_type	0.85
apoptosis pathway	participates_in	pathway	0.80
OPTN	regulates	gene	0.80
NBR1	regulates	gene	0.80
LC3	regulates	gene	0.80
oxidative stress response	participates_in	pathway	0.80
MAP1LC3	regulates	gene	0.80
neural stem cells	activates	cell_type	0.80
neural stem cells	regulates	cell_type	0.80
Parkinson	associated_with	disease	0.75
AMPK signaling	participates_in	pathway	0.70
GAPDH	regulates	gene	0.70
GFP	regulates	gene	0.70
MTOR	associated_with	gene	0.70
frontotemporal dementia	regulates	disease	0.70
ALS	regulates	disease	0.70
RB1CC1	associated_with	gene	0.70
WIPI2	associated_with	gene	0.70
NBR1	associated_with	gene	0.70
Parkinson's disease	regulates	disease	0.70
NLR	regulates	gene	0.70
RB1	activates	gene	0.70
PIK3C3	associated_with	gene	0.70
RNA	activates	gene	0.70
ALS	activates	disease	0.70
frontotemporal dementia	activates	disease	0.70
RNA	regulates	gene	0.70
RB1CC1	regulates	gene	0.70
FIP200	regulates	gene	0.70
RB1	regulates	gene	0.70
MAPK signaling	participates_in	pathway	0.70
PRKN	regulates	gene	0.70
PTEN	regulates	gene	0.70
Parkinson's disease	activates	disease	0.70
PINK1	regulates	gene	0.70
ULK1	regulates	gene	0.70
Mtor	associated_with	pathway	0.70
TAX1BP1	regulates	gene	0.70
Alzheimer's disease	associated_with	disease	0.70
NDP52	encodes	protein	0.70
Crohn's disease	associated_with	disease	0.70

Incoming (367)

Source	Relation	Type	Str
BEX2	interacts_with	protein	0.90
MARCHF8	interacts_with	protein	0.90
BST2	interacts_with	protein	0.90
Stress Granule Accumulation	associated_with	phenotype	0.85
MARCHF8	activates	protein	0.85
ATG	activates	gene	0.80
AUTOPHAGY	associated_with	gene	0.80
STING1	interacts_with	gene	0.70
TFEB	associated_with	gene	0.70
SQSTM1	associated_with	gene	0.70
PARKINSON	associated_with	gene	0.70
TRIM21	interacts_with	gene	0.70
RB1	associated_with	gene	0.70
ATP	activates	gene	0.70
ALS	regulates	gene	0.70
LC3	associated_with	gene	0.70
BECN1	associated_with	gene	0.70
NDP52	interacts_with	gene	0.70
BCL2	regulates	gene	0.70
OPTN	associated_with	gene	0.70
PEDV_N_protein	interacts_with	protein	0.64
DNA	expressed_in	gene	0.60
RNA	associated_with	gene	0.60
ABCD3	interacts_with	gene	0.60
AMPK	regulates	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
MUL1	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
HIF1A	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60
RHOT1	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
DRP1	interacts_with	gene	0.60
SESN2	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
BCL2L13	interacts_with	gene	0.60
SNCAIP	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
RIPK3	interacts_with	gene	0.60
EPAS1	interacts_with	gene	0.60
FIP200	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60
PTEN	interacts_with	gene	0.60
LAMP2A	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What determines the spatial organization of autophagy receptors at stress granul

neurodegeneration | 2026-04-08 | 5 hypotheses Top: 0.633

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

SQSTM1 and CALCOCO2 specifically localize to SG periphery rather than throughout

closed · Rounds: 4 · Score: 0.69 · 2026-04-21

Related Research

Hypotheses and analyses mentioning CALCOCO2 in their description or question text

No additional research found