protein

UBIQUITIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UBIQUITIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

4057Connections

6Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

UBIQUITIN is a protein involved in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with ALS, AMYOTROPHIC LATERAL SCLEROSIS, Aging. Connected to 2278 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	UBIQUITIN
Function	is a highly conserved 76-amino acid protein that covalently attaches to target proteins to mark them for various cellular fates.
Pathways	Adaptive Immunity, Akt, Angiogenesis, Apoptosis, Autophagy
GeneCards	UBIQUITIN
Human Protein Atlas	UBIQUITIN
19S Regulatory Cap	Recognizes polyubiquitinated substrates, removes ubiquitin chains (recycling ubiquitin), unfolds substrates, and translocates them into the core particle
20S Core Particle	Cylindrical proteolytic chamber with three distinct protease activities (beta1, beta2, beta5 subunits)
Associated Diseases	Aging, Als, Alzheimer, Alzheimer'S Disease, Amyotrophic Lateral Sclerosis
Known Drugs/Compounds	proteolysis-targeting chimeras, RAPAMYCIN
Interactions	ABCD3, ABLIM1, ACAT1, ACE, ACETYL-COA, ACOD1
KG Connections	3830 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Ubiquitin-Proteasome System Dysfunction in Corticobasal Syndrome

mechanism · 2085 words

→

Pathway Diagram

graph TD
    subgraph Signaling["Signaling"]
        UBIQUITIN["UBIQUITIN"] -->|"regulates"| Als["Als"]
        UBIQUITIN["UBIQUITIN"] -->|"regulates"| Apoptosis["Apoptosis"]
        UBIQUITIN["UBIQUITIN"] -->|"regulates"| Autophagy_1["Autophagy"]
        UBIQUITIN["UBIQUITIN"] -->|"activates"| Oxidative_Stress["Oxidative Stress"]
        UBIQUITIN["UBIQUITIN"] -->|"regulates"| Proteasome["Proteasome"]
        UBIQUITIN["UBIQUITIN"] -->|"regulates"| Ubiquitin_Proteasome["Ubiquitin-Proteasome"]
        UBIQUITIN["UBIQUITIN"] -->|"activates"| Als_2["Als"]
        UBIQUITIN["UBIQUITIN"] -->|"activates"| Cancer["Cancer"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"activates"| UBIQUITIN["UBIQUITIN"]
        TLR4["TLR4"] -->|"activates"| UBIQUITIN["UBIQUITIN"]
        NEURODEGENERATION["NEURODEGENERATION"] -->|"regulates"| UBIQUITIN["UBIQUITIN"]
    end
    subgraph Interactions["Interactions"]
        UBIQUITIN["UBIQUITIN"] -->|"interacts with"| Autophagy["Autophagy"]
    end
    subgraph Pathology["Pathology"]
        AUTOPHAGY["AUTOPHAGY"] -->|"associated with"| UBIQUITIN["UBIQUITIN"]
    end
    subgraph Therapeutic["Therapeutic"]
        PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"therapeutic target"| UBIQUITIN["UBIQUITIN"]
        NEURODEGENERATION_3["NEURODEGENERATION"] -->|"therapeutic target"| UBIQUITIN["UBIQUITIN"]
    end
    style UBIQUITIN fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
    style Als fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Apoptosis fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Autophagy fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Autophagy_1 fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Oxidative_Stress fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Proteasome fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Ubiquitin_Proteasome fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Als_2 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style OXIDATIVE_STRESS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style TLR4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style AUTOPHAGY fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style PARKINSON_S_DISEASE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style NEURODEGENERATION fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style NEURODEGENERATION_3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0

Outgoing (2139)

Target	Relation	Type	Str
MITOCHONDRIA	activates	gene	1.00
Infection	activates	disease	1.00
Neurodegeneration	activates	disease	1.00
Proteasome	therapeutic_target	pathway	1.00
DNA	regulates	gene	1.00
MITOCHONDRIA	regulates	gene	1.00
Immune Response	regulates	pathway	1.00
Proteasome	activates	pathway	1.00
Ubiquitin-Proteasome	therapeutic_target	pathway	1.00
Ubiquitin-Proteasome	activates	pathway	1.00
Mitophagy	regulates	pathway	1.00
Autophagy	therapeutic_target	pathway	1.00
Tumor	therapeutic_target	disease	1.00
Nf-Κb	activates	pathway	1.00
Parkinson	activates	disease	1.00
Cancer	therapeutic_target	disease	1.00
Neurodegeneration	regulates	disease	1.00
CANCER	therapeutic_target	gene	1.00
Carcinoma	activates	disease	1.00
Als	therapeutic_target	disease	1.00
Neurodegeneration	therapeutic_target	disease	1.00
Inflammation	regulates	disease	1.00
Inflammasome	activates	pathway	1.00
Parkinson	regulates	disease	1.00
Autophagy	interacts_with	pathway	1.00
Aging	activates	disease	1.00
Als	regulates	disease	1.00
Mitophagy	activates	pathway	1.00
Parkinson	therapeutic_target	disease	1.00
Inflammation	activates	disease	1.00
Als	activates	disease	1.00
Cancer	activates	disease	1.00
Tumor	activates	disease	1.00
Als	inhibits	disease	1.00
Apoptosis	regulates	pathway	1.00
Aging	associated_with	disease	1.00
Autophagy	regulates	pathway	1.00
Cancer	inhibits	disease	1.00
Als	interacts_with	disease	1.00
Oxidative Stress	activates	pathway	1.00
Proteasome	regulates	pathway	1.00
Tumor	regulates	disease	1.00
Ubiquitin-Proteasome	regulates	pathway	1.00
Parkinson	associated_with	disease	1.00
Autophagy	activates	pathway	1.00
Tumor	inhibits	disease	1.00
Proteasome	inhibits	pathway	1.00
Cancer	regulates	disease	1.00
CANCER	regulates	gene	1.00
Cell Cycle	regulates	pathway	1.00

Incoming (1918)

Source	Relation	Type	Str
ALZHEIMER	associated_with	gene	1.00
LYSOSOME	activates	gene	1.00
NEURODEGENERATION	activates	gene	1.00
AUTOPHAGY	activates	gene	1.00
NEURODEGENERATION	regulates	gene	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
PARKINSON'S DISEASE	associated_with	gene	1.00
INFLAMMATION	activates	gene	1.00
GENES	activates	gene	1.00
INFLAMMATION	regulates	gene	1.00
PARKINSON'S DISEASE	therapeutic_target	gene	1.00
PARKINSON	activates	gene	1.00
PARKINSON	associated_with	gene	1.00
NF-ΚB	activates	gene	1.00
MITOPHAGY	associated_with	gene	1.00
AUTOPHAGY	associated_with	gene	1.00
NLRP3	activates	gene	1.00
TLR4	activates	gene	1.00
KEAP1	interacts_with	gene	1.00
CANCER	regulates	gene	1.00
PINK1	regulates	gene	1.00
NEURODEGENERATION	therapeutic_target	gene	1.00
NEURODEGENERATION	associated_with	gene	1.00
CANCER	activates	gene	1.00
OXIDATIVE STRESS	activates	gene	1.00
CANCER	inhibits	gene	1.00
LYSOSOME	regulates	gene	1.00
MITOPHAGY	inhibits	gene	1.00
AUTOPHAGY	therapeutic_target	gene	1.00
PINK1	inhibits	gene	1.00
P62	regulates	gene	1.00
GENES	regulates	gene	1.00
OXIDATIVE STRESS	regulates	gene	1.00
PARKINSON	therapeutic_target	gene	1.00
APOPTOSIS	regulates	gene	1.00
TAU	associated_with	gene	0.98
AUTOPHAGY	regulates	gene	0.98
P62	associated_with	gene	0.98
PINK1	activates	gene	0.98
UBQLN2	interacts_with	protein	0.95
E1, E2, E3 enzymes	modulates	protein	0.95
FBXL7	mediates	protein	0.95
OPTN	associated_with	entity	0.95
OTUD6A	degrades	gene	0.95
E3 Ubiquitin Ligases	mediates	enzyme	0.95
USP9X	associated_with	gene	0.95
DUB	cleaves	enzyme	0.95
USP10	removes	protein	0.95
NEDD4L	interacts_with	protein	0.92
ABLIM1	interacts_with	protein	0.92

Targeting Hypotheses (6)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Ubiquitin-Mediated Liquid-to-Solid Transition Prevention	0.730	neurodegeneration	How does TRIM21-mediated K63 ubiquitinat
VCP/p97 ATPase mutations impair extraction of ubiquitinated	0.720	neurodegeneration	What are the neuron-specific effects of
Differential Ubiquitin Chain Topology Creates 'Invisible' Su	0.682	neurodegeneration	How do pathological stress granules in n
Displacement of G3BP1 RGG Box from Target RNA via Ubiquitin-	0.600	neurodegeneration	How does TRIM21-mediated K63 ubiquitinat
CHIP-mediated ubiquitination selectively targets oligomeric	0.580	protein biochemistry	Do chaperones selectively recognize path

TRIM21-Mediated Ubiquitination Creates Peripheral Epitope Gr	0.548	neurodegeneration	What determines the spatial organization

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (15)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Proof of concept: targeted protein degradation of the stress granules component [PMID:41586493]	Unknown	Antimicrobial agents and chemo	2026
Stress granules: Guardians of cellular health and triggers of disease. [PMID:39995077]	["Desai M", "Gulati K", "Agrawal M", "Gh	Neural regeneration research	2026
Implications of virus-induced stress granules in tauopathies. [PMID:41673769]	Sharma S, Vandenakker A, Cortés-Pérez C,	Translational neurodegeneratio	2026
Stress granules: Guardians of cellular health and triggers of disease. [PMID:39995077]	Desai M, Gulati K, Agrawal M, Ghumra S,	Neural Regen Res	2026
Uridine analogs prevent stress granule formation, not by blocking PKR recognitio [PMID:41571440]	Ihn SJ, Jiang E, Kejiou NS, Wang YE, Far	RNA	2026
Proof of concept: targeted protein degradation of the stress granules component [PMID:41586493]	Echavarria-Consuegra L, Goodfellow I	Antimicrob Agents Chemother	2026
Atg5/Autophagy inactivation in mouse bone microenvironment promotes tumor develo [PMID:41612597]	Trojani MC, Nollet M, Camuzard O, Santuc	Autophagy	2026
High expression of G3BP1 is associated with poor prognosis in breast invasive ca [PMID:41635545]	Li J, Zong Z, Shen J, Wang J, Zhou X et	Oncol Lett	2026
Implications of virus-induced stress granules in tauopathies. [PMID:41673769]	Sharma S, Vandenakker A, Cortés-Pérez C,	Transl Neurodegener	2026
Dysregulated miRNAs and downstream gene expression associated with poor treatmen [PMID:41694232]	Yu SC, Wang YC, Lin HP, Jen YW, Hwang TJ	Brain Behav Immun Health	2026
Pharmacological modulation of stress granules via G3BP1/2: A pathway to treat ca [PMID:41924133]	Yang J, Gao F	Front Pharmacol	2026
Stress granules at the crossroads of retroviral replication and antiviral immuni [PMID:41931190]	Akbarin MM, Farjami Z, Álvarez HR	Mol Biol Rep	2026
Targeting G3BP1-Mediated Stress Granules to Suppress SARS-CoV-2 Replication. [PMID:41960678]	Aromokeye R, Kuang L, Ackerman-Berrier M	ACS Infect Dis	2026
The neuroprotective effect of Cucurbitacin B against Aβ and tau toxicities requi [PMID:42012542]	Tu X, Fang M, Yan Y, Liu Y, Yu J et al.	Biogerontology	2026
Pharmacological modulation of stress granules via G3BP1/2: A pathway to treat ca [PMID:41924133]	Yang J, Gao F	Frontiers in pharmacology	2026

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning UBIQUITIN in their description or question text

TRIM21-Mediated Ubiquitination Creates Peripheral Epitope Gradient via K63-Linke

Score: 0.548 · neurodegeneration · 2026-04-21

## Mechanistic Overview TRIM21-Mediated Ubiquitination Creates Peripheral Epitope Gradient via K63-Linked Chain Accumula