protein

DRP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DRP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1700Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

DRP1 is a protein involved in neurodegeneration research. Key relationships include: interacts with, activates, regulates. Associated with AD, ALI, ALS. Connected to 777 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	DRP1
Protein Type	Enzyme
Function	The DRP1 gene encodes a 736-amino acid GTPase
Pathways	Apoptosis, Autophagy, Cell Cycle, Complement, Dna Methylation
Ensembl ID	ENSG00000141971
GeneCards	DRP1
Human Protein Atlas	DRP1
N-terminal GTPase domain	Catalyzes GTP hydrolysis (residues 1-300)
Middle domain	Mediates self-assembly and dimerization
GTPase effector domain (GED)	Stimulates GTPase activity upon oligomerization
C-terminal variable region	Determines mitochondrial recruitment and interactions
Fis1	Tail-anchored protein that serves as a minimal DRP1 receptor
MiD49/MiD50	Mitochondrial dynamics proteins that enhance DRP1 recruitment
MFF	Mitochondrial fission factor, the primary DRP1 receptor in most tissues
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	ginsenoside Re, Ginsenoside Re, Mdivi-1, Palmitic Acid, propionic acid, Rg1
Interactions	ABCD3, ABCG2, Actin, ADORA2A, AGING, AKT
KG Connections	1696 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    DRP1(["DRP1"])
    MITOPHAGY(["MITOPHAGY"])
    Mitophagy["Mitophagy"]
    Als["Als"]
    Cancer["Cancer"]
    Mitochondrial_Derived_Vesicle_Biogenesis("Mitochondrial-Derived Vesicle Bi...")
    MITOCHONDRIAL_DERIVED_VESICLES["MITOCHONDRIAL-DERIVED VESICLES"]
    DNA(["DNA"])
    Mitochondrial_Function["Mitochondrial Function"]
    MITOCHONDRIA(["MITOCHONDRIA"])
    MITOCHONDRIAL_DNA(["MITOCHONDRIAL DNA"])
    Neurodegeneration["Neurodegeneration"]
    Autophagy["Autophagy"]
    Apoptosis["Apoptosis"]

    MITOPHAGY -->|"activates"| DRP1
    DRP1 -->|"activates"| Mitophagy
    DRP1 -->|"activates"| Als
    DRP1 -->|"activates"| Cancer
    DRP1 -->|"mediates"| Mitochondrial_Derived_Vesicle_Biogenesis
    DRP1 -->|"regulates"| MITOCHONDRIAL_DERIVED_VESICLES
    DRP1 -->|"regulates"| Mitophagy
    DRP1 -->|"activates"| DNA
    DRP1 -.->|"inhibits"| Mitochondrial_Function
    DRP1 -->|"activates"| MITOCHONDRIA
    MITOPHAGY -->|"regulates"| DRP1
    MITOCHONDRIAL_DNA -->|"activates"| DRP1
    DRP1 -->|"implicated in"| Neurodegeneration
    DRP1 -->|"activates"| Autophagy
    DRP1 -->|"activates"| Apoptosis

    style DRP1 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (1084)

Target	Relation	Type	Str
Mitophagy	activates	pathway	1.00
Mitochondrial Dysfunction	regulates	process	0.95
Serine 616	phosphorylates	biomarker	0.95
Mitochondrial Dynamics	involved_in	process	0.95
Membrane Scission	mediates	process	0.95
Mitochondrial-Derived Vesicle Biogenesis	promotes	process	0.95
mitochondrial-derived vesicle biogenesis	drives	process	0.95
MITOCHONDRIAL-DERIVED VESICLES	regulates	entity	0.95
Mitochondrial Fragmentation	activates	process	0.95
Cancer	activates	disease	0.95
Mitochondrial-Derived Vesicle Biogenesis	mediates	process	0.95
Mitochondrial Fragmentation	mediates	process	0.95
Mitochondrial-Derived Vesicle Biogenesis	activates	process	0.95
Als	activates	disease	0.95
Purkinje Cell Apoptosis	regulates	process	0.95
Axonal Degeneration	mediates	process	0.92
Neuronal Degeneration	involved_in	phenotype	0.91
Cerebellar Ataxia	associated_with	disease	0.90
oxidative stress response	participates_in	pathway	0.90
mitochondrial dynamics	participates_in	pathway	0.90
Retinal Ganglion Neuron Degeneration	protects_against	phenotype	0.90
Mitochondrial Dynamics	regulates	process	0.90
Mitochondrial Fission	mediates	process	0.90
Mitochondrial Fission	promotes	process	0.90
MITOCHONDRIA	activates	gene	0.90
Mitophagy	regulates	pathway	0.90
DNA	activates	gene	0.90
Mitochondrial Function	inhibits	pathway	0.90
Mitochondrial Fission	regulates	process	0.85
Neuronal Cell Death	mediates	phenotype	0.85
mitochondrial fission	regulates	phenotype	0.85
mitochondrial fragmentation	mediates	phenotype	0.85
Tumor Growth	mediates	phenotype	0.85
Alzheimer's Disease	biomarker_for	disease	0.85
Parkinson's disease	involved_in	disease	0.85
Tumor Growth	contributes_to	phenotype	0.85
mitochondrial fission	regulates	process	0.85
Neurodegeneration	associated_with	disease	0.85
vascular leakage	drives	phenotype	0.80
mitophagy	regulates	pathway	0.80
Purkinje cells	causes	cell_type	0.80
Purkinje cells	regulates	cell_type	0.80
Axotomy	targets	process	0.80
Ginsenoside Re	binds	compound	0.80
Chemotherapy-induced peripheral neuropathy	involved_in	disease	0.80
Mitochondrial Dysfunction	involved_in	phenotype	0.80
mitochondrial function	participates_in	pathway	0.80
mitochondrial dynamics	mediates	biological_process	0.80
Autophagy	activates	pathway	0.80
NEURON	activates	gene	0.80

Incoming (616)

Source	Relation	Type	Str
MITOPHAGY	activates	gene	1.00
genes-drp1	linked_to	wiki_page	1.00
Mdivi-1	inhibits	drug	0.95
Rg1	inhibits	compound	0.95
PGAM5	promotes	protein	0.95
MAPK	phosphorylates	pathway	0.90
ataluren	associated_with	drug	0.90
Paclitaxel	upregulates	drug	0.90
DIZE	upregulates	drug	0.90
DLK	phosphorylates	protein	0.90
genes-drp1	describes	wiki	0.90
MITOPHAGY	regulates	gene	0.90
MITOCHONDRIAL DNA	activates	gene	0.90
Palmitic Acid	phosphorylates	compound	0.85
endothelial cell	expressed_in	cell_type	0.85
AMYLOID-BETA	upregulates	protein	0.85
MAP3K12	phosphorylates	gene	0.85
Aging	upregulates	process	0.85
GJA1-20k	associated_with	protein	0.85
PM10	upregulates	compound	0.85
E2F1	regulates	gene	0.80
MIROS	drives	protein	0.80
Onconase	downregulates	drug	0.80
MTOR	modulates	protein	0.80
Palmitic Acid	modulates	compound	0.80
OPA1	activates	gene	0.80
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.80
APOPTOSIS	regulates	gene	0.80
AUTOPHAGY	activates	gene	0.80
OXIDATIVE STRESS	regulates	gene	0.80
CANCER	activates	gene	0.80
PINK1	activates	gene	0.80
NEURODEGENERATION	implicated_in	gene	0.80
PGAM5	regulates	protein	0.72
phosphorylated tau	interacts_with	protein	0.70
GPR41	regulates	protein	0.70
Zuo Gui Wan	inhibits	drug	0.70
Phosphorylated tau	interacts_with	protein	0.70
APOE4	activates	protein	0.70
HSF1	activates	protein	0.70
APOPTOSIS	activates	gene	0.70
PINK1	associated_with	gene	0.70
Copper	activates	drug	0.70
propionic acid	inhibits	drug	0.70
CLDN5	inhibits	gene	0.70
ginsenoside Re	binds	drug	0.70
CLDN5	protects_against	gene	0.70
FUNDC1	interacts_with	gene	0.70
amyloid beta	interacts_with	protein	0.70
Amyloid beta	interacts_with	protein	0.70

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Drp1-S616 Phosphorylation Fission Priming Enables t-Bid-Driv	0.693	neurodegeneration	What upstream mechanisms cause TDP-43 to

Mentioning Analyses (1)

Scientific analyses that reference this entity

Mitochondrial transfer between astrocytes and neurons

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.813

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Mitochondrial transfer between astrocytes and neurons

closed · Rounds: 4 · Score: 0.95 · 2026-04-06

Related Research

Hypotheses and analyses mentioning DRP1 in their description or question text

No additional research found

DRP1

Understanding Entity Pages

Summary

Wiki Pages (4)

DRP1 (Dynamin-Related Protein 1)

DRP1 Protein (Dynamin-1-like Protein)

DRP1 Protein

DRP1 Gene - Dynamin 1-Like Protein

Pathway Diagram

Outgoing (1084)

Incoming (616)

Targeting Hypotheses (1)

Mentioning Analyses (1)

Mitochondrial transfer between astrocytes and neurons

Experiments (0)

Related Papers (0)

Debates (1)

Mitochondrial transfer between astrocytes and neurons

Related Research