gene

DNM1L

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNM1L: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

970Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

DNM1L is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with AD, ALI, ALS. Connected to 466 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	DNM1L
Full Name	Dynamin 1 Like (Dynamin-Related Protein 1)
Chromosome	12p11.21
Function	DRP1 orchestrates mitochondrial fission
Primary Expression	astrocytes and microglia
Pathways	Apoptosis, Mitochondrial Function, Mitophagy, Oxidative Stress
UniProt ID	[O00429](https://www.uniprot.org/uniprot/O00429)
Ensembl ID	ENSG00000087470
GeneCards	DNM1L
Human Protein Atlas	DNM1L
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	metformin, rapamycin
Interactions	ABCD3, ADORA2A, AIF1, AKT, ALS, ALZHEIMER
KG Connections	969 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DNM1L Gene

gene · 646 words

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Pathway Diagram

graph TD
    DNM1L["DNM1L"] -->|"Interacts With"| Dementia["Dementia"]
    DNM1L["DNM1L"] -->|"Interacts With"| Cardiovascular["Cardiovascular"]
    DNM1L["DNM1L"] -->|"Interacts With"| Als["Als"]
    DNM1L["DNM1L"] -->|"Interacts With"| Alzheimer["Alzheimer"]
    DNM1L["DNM1L"] -->|"Interacts With"| Parkinson["Parkinson"]
    DNM1L["DNM1L"] -->|"Interacts With"| Ms["Ms"]
    DNM1L["DNM1L"] -->|"Activates"| Cancer["Cancer"]
    DNM1L["DNM1L"] -->|"Activates"| Inflammation["Inflammation"]
    CKLF["CKLF"] -->|"Increases Risk"| DNM1L["DNM1L"]
    CKLF1["CKLF1"] -->|"Increases Risk"| DNM1L["DNM1L"]
    ROS["ROS"] -->|"Activates"| DNM1L["DNM1L"]
    CAT["CAT"] -->|"Interacts With"| DNM1L["DNM1L"]
    OPTN["OPTN"] -->|"Interacts With"| DNM1L["DNM1L"]
    style DNM1L fill:#8d4900,color:#e0e0e0
    style Dementia fill:#b71c1c,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Alzheimer fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Inflammation fill:#b71c1c,color:#e0e0e0
    style CKLF fill:#0d47a1,color:#e0e0e0
    style CKLF1 fill:#8d4900,color:#e0e0e0
    style ROS fill:#607D8B,color:#e0e0e0
    style CAT fill:#8d4900,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0

Outgoing (559)

Target	Relation	Type	Str
DNM1L	encodes	protein	0.00
Mitofission	mediates	process	0.95
Mitochondrial Division	mediates	process	0.92
Mitochondrial Fission	promotes	process	0.92
Mitochondrial Fission	mediates	process	0.90
mitochondrial dynamics	regulates	process	0.80
autophagy pathway	participates_in	pathway	0.80
oxidative stress response	participates_in	pathway	0.80
Mitochondrial Homeostasis	regulates	process	0.75
ubiquitin-proteasome	participates_in	pathway	0.70
neural stem cells	activates	cell_type	0.70
LC3	regulates	gene	0.70
LC3	interacts_with	gene	0.70
PINK1	biomarker_for	gene	0.70
RB1CC1	regulates	gene	0.70
ROS	regulates	gene	0.70
MAP1LC3B	regulates	gene	0.70
RB1	regulates	gene	0.70
PRKN	regulates	gene	0.70
MAP1LC3B	interacts_with	gene	0.70
LC3B	interacts_with	gene	0.70
PTEN	biomarker_for	gene	0.70
RB1	activates	gene	0.70
TFAM	activates	gene	0.70
Mitophagy	interacts_with	pathway	0.70
UBIQUITIN	associated_with	gene	0.70
PRKN	associated_with	gene	0.70
Mitophagy	associated_with	pathway	0.70
DRP1	interacts_with	gene	0.70
Mitophagy	activates	pathway	0.70
Autophagy	activates	pathway	0.70
mitochondrial dysfunction	biomarker_for	process	0.68
ALS	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Ftd	interacts_with	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Tumor	expressed_in	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Cancer	expressed_in	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Heart Failure	inhibits	disease	0.65
Cancer	activates	disease	0.65
Tumor	regulates	disease	0.65
Als	therapeutic_target	disease	0.65
Colorectal Cancer	activates	disease	0.65
Infection	activates	disease	0.65
Glioblastoma	regulates	disease	0.65
Ms	inhibits	disease	0.65
Aging	regulates	disease	0.65

Incoming (411)

Source	Relation	Type	Str
DNM1L	encodes	gene	0.00
Ros	phosphorylates	process	0.90
AKT	phosphorylates	protein	0.90
Reactive Oxygen Species	phosphorylates	process	0.90
AKT	regulates	entity	0.85
CKLF	upregulates	protein	0.85
CKLF	contributes_to	protein	0.80
CKLF1	contributes_to	gene	0.80
PRKAA	activates	gene	0.80
ROS	activates	phenotype	0.74
MITOPHAGY	associated_with	gene	0.70
MITOPHAGY	interacts_with	gene	0.70
PINK1	associated_with	gene	0.70
ATG	activates	gene	0.70
FUNDC1	interacts_with	gene	0.70
ATG	regulates	gene	0.70
MFF	associated_with	gene	0.70
AUTOPHAGY	activates	gene	0.70
MITOPHAGY	activates	gene	0.70
PTEN	activates	gene	0.60
PRKN	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
AMBRA1	interacts_with	gene	0.60
BNIP3	interacts_with	gene	0.60
OVERVIEW	regulates	gene	0.60
BCL2	interacts_with	gene	0.60
ABCD3	activates	entity	0.60
AMBRA1	activates	entity	0.60
ATM	activates	entity	0.60
BCL2	activates	entity	0.60
BCL2L11	activates	entity	0.60
BCL2L13	activates	entity	0.60
BNIP3	activates	entity	0.60
BNIP3L	activates	entity	0.60
CALCOCO2	activates	entity	0.60
CANX	activates	entity	0.60
CAT	activates	entity	0.60
CHOP	activates	entity	0.60
CTSD	activates	entity	0.60
ADORA2A	regulates	entity	0.60
AMBRA1	regulates	entity	0.60
BCL2	regulates	entity	0.60
BNIP3	regulates	entity	0.60
BNIP3L	regulates	entity	0.60
BNIP3L	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
ATM	regulates	gene	0.60
BCL2L13	regulates	gene	0.60
BECN1	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DNM1L in their description or question text

No additional research found