gene

BECN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BECN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3143Connections

0Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

3Debates

Summary

BECN1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, activates. Associated with AD, ALI, ALS. Connected to 1696 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	BECN1
Function	BECN1 encodes beclin-1, a key regulator of autophagy—a cellular process for degrading and recycling damaged organelles, protein aggregates, and intracellular pathogens.
Molecular Weight	60 kDa
Pathways	Akt, Apoptosis, Autophagy, Car-T, Epigenetic
UniProt ID	Q9Y5P6
Ensembl ID	ENSG00000126581
GeneCards	BECN1
Human Protein Atlas	BECN1
Autophagosome Maturation	Recruits ATG proteins and facilitates membrane closure
Endocytic Trafficking	Regulates endocytic pathway and vacuolar protein sorting
Tumor Suppression	Functions as a haploinsufficient tumor suppressor
Associated Diseases	AD, ALI, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	crocin, HCQ, Isorhapontigenin, nicotine, rapamycin, RAPAMYCIN
Interactions	ABCD3, ACAT1, ACETYL-COA, ACHE, ACOX1, ACTB
KG Connections	3143 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: BECN1 — AlphaFold Q9Y5P6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    BECN1["BECN1"] <-->|"interacts with"| Amyotrophic_Lateral_Scler["Amyotrophic Lateral Sclerosis"]
    BECN1["BECN1"] <-->|"interacts with"| Dementia["Dementia"]
    BECN1["BECN1"] <-->|"interacts with"| Als["Als"]
    BECN1["BECN1"] <-->|"interacts with"| Cardiovascular["Cardiovascular"]
    BECN1["BECN1"] <-->|"interacts with"| Alzheimer["Alzheimer"]
    BECN1["BECN1"] <-->|"interacts with"| Parkinson["Parkinson"]
    BECN1["BECN1"] <-->|"interacts with"| Ms["Ms"]
    BECN1["BECN1"] <-->|"interacts with"| Cancer["Cancer"]
    BECN1["BECN1"] -->|"regulates"| Fibrosis["Fibrosis"]
    BECN1["BECN1"] ---|"associated with"| Amyotrophic_Lateral_Scler["Amyotrophic Lateral Sclerosis"]
    BECN1["BECN1"] -->|"activates"| Neurodegeneration["Neurodegeneration"]
    BECN1["BECN1"] ---|"associated with"| Ataxia["Ataxia"]
    style BECN1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0
    style Amyotrophic_Lateral_Scler fill:#ef5350,stroke:#333,color:#e0e0e0
    style Dementia fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cardiovascular fill:#ef5350,stroke:#333,color:#e0e0e0
    style Alzheimer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Parkinson fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Fibrosis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Neurodegeneration fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ataxia fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (2176)

Target	Relation	Type	Str
MTOR	activates	gene	1.00
AUTOPHAGY	associated_with	gene	1.00
autophagy	associated_with	pathway	1.00
SQSTM1	activates	gene	1.00
autophagy	activates	pathway	1.00
PIK3C3	associated_with	gene	1.00
autophagy	regulates	process	1.00
Autophagy	associated_with	pathway	1.00
AUTOPHAGY	activates	pathway	1.00
Inflammation	activates	disease	1.00
Autophagy	regulates	pathway	1.00
Autophagy	activates	pathway	1.00
CANCER	activates	gene	1.00
Autophagy	inhibits	pathway	1.00
APOPTOSIS	associated_with	gene	1.00
Ferroptosis	activates	pathway	1.00
Cancer	activates	disease	1.00
P62	activates	gene	1.00
Als	activates	disease	1.00
Mtor	associated_with	pathway	1.00
MTOR	associated_with	gene	1.00
ATG	associated_with	gene	1.00
AUTOPHAGY	inhibits	gene	1.00
Apoptosis	activates	pathway	1.00
LC3	activates	gene	0.98
Tumor	associated_with	disease	0.95
Tumor	activates	disease	0.95
Als	regulates	disease	0.95
Cancer	regulates	disease	0.95
autophagosome biogenesis	necessary_for	process	0.95
STEM CELLS	activates	cell_type	0.95
S-palmitoylation	substrate_of	process	0.95
RAPAMYCIN	activates	drug	0.95
CD19 CAR-T cell cytotoxicity resistance	promotes	phenotype	0.92
Autophagy	involved_in	process	0.91
autophagy	promotes	process	0.90
lipolysis	promotes	process	0.90
mitophagy	associated_with	pathway	0.90
RNA	activates	gene	0.90
ER stress response	regulates	process	0.90
cancer cell evasion from CAR-T cells	enables	process	0.90
SYSTEM XC-	inhibits	receptor	0.90
inflammation	inhibits	phenotype	0.90
apoptosis pathway	participates_in	pathway	0.90
tibial nerve	expressed_in	brain_region	0.90
LC3	upregulates	entity	0.90
neural stem cells	regulates	cell_type	0.90
PIK3C3/VPS34	interacts_with	protein	0.90
autophagy	involved_in	process	0.90
MAP1LC3	regulates	gene	0.90

Incoming (967)

Source	Relation	Type	Str
ROS	activates	gene	1.00
AUTOPHAGY	activates	gene	1.00
AMPK	activates	gene	0.98
ESM1	regulates	protein	0.95
AMPK	phosphorylates	protein	0.95
ATXN3	associated_with	gene	0.95
PKD2	interacts_with	protein	0.92
rapamycin	targets	drug	0.90
IL-6	phosphorylates	entity	0.90
Thermal Adaptation	upregulates	process	0.90
Acetylation	modulates	process	0.90
Autophagy	upregulates	process	0.90
ULK1	phosphorylates	protein	0.90
paeoniflorin	contributes_to	drug	0.90
LRPPRC	interacts_with	protein	0.90
Dopamine-Conjugated Extracellular Vesicles	upregulates	compound	0.90
BCL2	binds	gene	0.90
KLF10	regulates	protein	0.88
VCP	interacts_with	protein	0.88
Thermal adaptation	upregulates	process	0.85
nicotine	activates	drug	0.85
TFEB	upregulates	protein	0.85
curcumin	upstream_of	drug	0.85
crocin	inhibits	drug	0.85
RUBCN	interacts_with	protein	0.85
LYPLAL1-DT	interacts_with	gene	0.85
GXN	binds_to	drug	0.85
aging	inhibits	phenotype	0.85
RUBCNL	interacts_with	protein	0.85
CB13	upregulates	drug	0.83
BCL2	activates	gene	0.82
ALZHEIMER'S DISEASE	associated_with	gene	0.82
ALS	activates	disease	0.82
VCP	associated_with	protein	0.80
CKLF	contributes_to	protein	0.80
LYC	contributes_to	drug	0.80
CKLF1	contributes_to	gene	0.80
CKLF	upregulates	protein	0.80
ATG	component_of	gene	0.80
ACTB	regulates	gene	0.80
AR	activates	gene	0.80
HCQ	modulates	drug	0.80
JNK	upstream_of	protein	0.80
MAP1LC3B	participates_in	gene	0.80
ubiquitin	modifies	protein	0.80
CLOCK	regulates	gene	0.80
MLKL	regulates	gene	0.80
CUL3	inhibits	gene	0.80
SQSTM1	participates_in	gene	0.80
caspases	inhibits	protein	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (3)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

BECN1

Understanding Entity Pages

Summary

Wiki Pages (6)

BECN1 Gene

BECN1 Protein (Beclin-1)

Beclin 1 (BECN1)

BECN1 Protein

Beclin-1 (BECN1) Neurons

BECN1 Gene

Pathway Diagram

Outgoing (2176)

Incoming (967)

Targeting Hypotheses (0)

Mentioning Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving mediators

Autophagy-lysosome pathway convergence across neurodegenerative diseases

Mechanistic role of APOE in neurodegeneration

Experiments (0)

Related Papers (0)

Debates (3)

Multiple NDDs converge on autophagy-lysosome dysfunction. Are there universal th

SPMs (resolvins, protectins, maresins) from omega-3s may promote inflammation re

Analysis question not specified