gene

GABA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GABA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1381Connections

3Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

GABA is a gene implicated in neurodegeneration research. Key relationships include: co discussed, activates, associated with. Associated with ALS, ALZHEIMER'S DISEASE, PARKINSON'S DISEASE. Connected to 67 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	GABA
Chromosome	12p12.3
Function	is a hallmark of neurodegeneration.
Primary Expression	hippocampus, cortex, cerebellum, thalamus, hypothalamus
Amino Acids	602 aa
Exons	14
Pathways	GABAergic Signaling
GeneCards	GABA
Human Protein Atlas	GABA
Associated Diseases	Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	rapamycin
Interactions	ABCA7, ACTB, Actin, Akt, AKT, AKT1
KG Connections	1381 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GABA["GABA"]
    JNK["JNK"]
    GABA -->|"co discussed"| JNK
    LC3["LC3"]
    GABA -->|"co discussed"| LC3
    LRRK2["LRRK2"]
    GABA -->|"co discussed"| LRRK2
    MTOR["MTOR"]
    GABA -->|"co discussed"| MTOR
    ULK1["ULK1"]
    GABA -->|"co discussed"| ULK1
    HISTONE["HISTONE"]
    GABA -->|"co discussed"| HISTONE
    ISCHEMIA["ISCHEMIA"]
    GABA -->|"co discussed"| ISCHEMIA
    HTT["HTT"]
    GABA -->|"co discussed"| HTT
    MITOCHONDRIA["MITOCHONDRIA"]
    GABA -->|"co discussed"| MITOCHONDRIA
    MITOPHAGY["MITOPHAGY"]
    GABA -->|"co discussed"| MITOPHAGY
    PINK1["PINK1"]
    GABA -->|"co discussed"| PINK1
    HYPOTHALAMUS["HYPOTHALAMUS"]
    GABA -->|"co discussed"| HYPOTHALAMUS
    CRH["CRH"]
    CRH -->|"regulates"| GABA
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"co discussed"| GABA
    EPILEPSY["EPILEPSY"]
    EPILEPSY -->|"co discussed"| GABA
    APP["APP"]
    APP -->|"co discussed"| GABA
    BECN1["BECN1"]
    BECN1 -->|"co discussed"| GABA
    DEMENTIA["DEMENTIA"]
    DEMENTIA -->|"co discussed"| GABA
    FRONTOTEMPORAL["FRONTOTEMPORAL"]
    FRONTOTEMPORAL -->|"co discussed"| GABA
    FTD["FTD"]
    FTD -->|"co discussed"| GABA
    CIRCADIAN["CIRCADIAN"]
    CIRCADIAN -->|"co discussed"| GABA
    DOPAMINERGIC["DOPAMINERGIC"]
    DOPAMINERGIC -->|"co discussed"| GABA
    DEPRESSION["DEPRESSION"]
    DEPRESSION -->|"co discussed"| GABA
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"co discussed"| GABA
    style GABA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (893)

Target	Relation	Type	Str
GABARAP	regulates	gene	0.90
oxidative stress response	participates_in	pathway	0.90
RNA	regulates	gene	0.80
neural stem cells	regulates	cell_type	0.80
HDAC3	inhibits	gene	0.80
RNA	activates	gene	0.80
ULK1	activates	gene	0.80
ULK1	regulates	gene	0.80
LC3	regulates	gene	0.80
TFEB	activates	gene	0.80
TFEB	regulates	gene	0.80
neural stem cells	activates	cell_type	0.80
cortex	expressed_in	brain_region	0.80
MTOR	regulates	gene	0.80
hippocampus	expressed_in	brain_region	0.80
neurons	inhibits	cell_type	0.80
MTOR	activates	gene	0.80
serotonin	associated_with	neurotransmitter	0.80
LC3	activates	gene	0.80
neurons	activates	cell_type	0.70
RB1	activates	gene	0.70
GABRA1	inhibits	gene	0.70
COGNITIVE DECLINE	inhibits	phenotype	0.70
stem cells	expressed_in	cell_type	0.70
neurodegeneration	expressed_in	disease	0.70
NEUROINFLAMMATION	treats	phenotype	0.70
RB1CC1	regulates	gene	0.70
serotonin receptor	expressed_in	receptor	0.70
ALZHEIMER'S DISEASE	causes	disease	0.70
GABAergic neurons	expressed_in	cell_type	0.70
LAMP2	regulates	gene	0.70
NMDA receptor	expressed_in	receptor	0.70
TREM2	regulates	gene	0.70
MICROGLIA	activates	cell_type	0.70
AQP4	causes	gene	0.70
Alzheimer's disease	targets	disease	0.70
neurons	expressed_in	cell_type	0.70
EXCITOTOXICITY	protects_against	phenotype	0.70
RAS	activates	gene	0.70
SQSTM1	regulates	gene	0.70
RB1	regulates	gene	0.70
MTORC1	regulates	gene	0.70
autophagy pathway	participates_in	pathway	0.70
PIK3C3	regulates	gene	0.70
RAS	regulates	gene	0.70
MAP1LC3B	regulates	gene	0.70
EXCITOTOXICITY	inhibits	phenotype	0.70
GABA-A receptor	inhibits	receptor	0.70
neurons	associated_with	cell_type	0.70
NEUROINFLAMMATION	inhibits	phenotype	0.70

Incoming (488)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	0.98
rapamycin	targets	drug	0.90
MTOR	activates	gene	0.80
ATG	regulates	gene	0.80
ATG	activates	gene	0.80
SLC6A13	associated_with	gene	0.80
BACE1	causes	gene	0.70
NEURONS	produces	cell_type	0.70
BDNF	treats	gene	0.70
AR	activates	gene	0.70
ASTROCYTE	associated_with	gene	0.70
BACE1	associated_with	gene	0.70
BECN1	regulates	gene	0.70
TAU	associated_with	protein	0.70
DNA	regulates	gene	0.70
CASP3	associated_with	gene	0.66
PI3K	activates	gene	0.66
BDNF	associated_with	gene	0.66
PARKINSON'S DISEASE	associated_with	disease	0.66
RILUZOLE	regulates	drug	0.65
OXIDATIVE STRESS	treats	phenotype	0.65
DOPAMINE	inhibits	phenotype	0.65
RETINA	inhibits	brain_region	0.65
AUTOPHAGY	regulates	phenotype	0.65
BDNF	targets	gene	0.65
AKT	causes	gene	0.65
OXIDATIVE STRESS	activates	phenotype	0.65
LC3	activates	protein	0.64
MAP1LC3A	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
VAMP8	associated_with	gene	0.60
LYSOSOME	associated_with	gene	0.60
RRAGB	interacts_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
PRKN	associated_with	gene	0.60
AKT1S1	interacts_with	gene	0.60
GABARAPL1	associated_with	gene	0.60
VAMP7	associated_with	gene	0.60
RB1	associated_with	gene	0.60
RPS6KB1	interacts_with	gene	0.60
SNAP29	associated_with	gene	0.60
NBR1	interacts_with	gene	0.60
RRAGA	interacts_with	gene	0.60
STX17	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
AND	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
CASP3	interacts_with	gene	0.60
P38	interacts_with	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
APOE4 astrocytes fail to supply sufficient cholesterol to pa	0.500	neuroscience	APOE4-driven lipid metabolism dysregulat
Astrocytic APOE4 Disruption of GABAergic Support Increasing	0.450	neurodegeneration	How does APOE4 mechanistically increase
GABAergic Hub Stabilization Through α5-Subunit Inverse Agoni	0.420	connectomics	Human connectome alterations in Alzheime

Mentioning Analyses (1)

Scientific analyses that reference this entity

Metabolomic signatures of neurodegeneration and energy metabolism dysfunction

neurodegeneration | 2026-04-04 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

How do metabolomic alterations in glucose metabolism, mitochondrial function, an

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Related Research

Hypotheses and analyses mentioning GABA in their description or question text

No additional research found

GABA

Understanding Entity Pages

Summary

Wiki Pages (21)

GABAergic Neurons — Cell Type Hierarchy

Ventral Pallidum GABAergic Neurons

Alzheimer's Disease GABA Receptor and Excitotoxicity Therapy Companies

GABAergic Signaling Pathway in Neurodegeneration

Substantia Nigra Pars Reticulata GABAergic Output Neurons

Gamma-Aminobutyric Acid (GABA)

Zona Incerta GABAergic Neurons

GABAergic Preoptic Area Neurons

Globus Pallidus Externus GABAergic Neurons

GABA-B Receptor Protein

GABARAP Protein

GABAergic Neurons in Neurodegeneration

Substantia Nigra Pars Reticulata GABA Output Neurons

GABA-B Receptor Neurons

GABRG1 — GABA-A Receptor Subunit Gamma 1

GABAergic System Dysfunction in PSP

Tuberomammillary Nucleus GABA Neurons

Substantia Nigra Pars Reticulata GABA Neurons

Amygdala Central Nucleus GABA Output Neurons

GABRQ — GABA-A Receptor Theta Subunit

GABA (Gamma-Aminobutyric Acid) - Neurodegenerative Disease Biomarker