gene

RB1CC1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RB1CC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1183Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

RB1CC1 (FIP200) - autophagy initiation scaffold protein, key in neurodegeneration

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🧬 Gene Info

Gene Symbol	RB1CC1
Aliases	FIP200
Chromosome	8q11.23
Protein Type	Kinase
Function	encodes a large scaffolding protein that plays essential roles in autophagy, mitophagy, cell cycle regulation, and tumor suppression.
Molecular Weight	200 kDa
Amino Acids	894 aa
Pathways	Akt, Apoptosis, Autophagy, Car-T, Immunotherapy
UniProt ID	Q8TDW5
NCBI Gene ID	9821
Ensembl ID	ENSG00000051596
OMIM	606082
GeneCards	RB1CC1
Human Protein Atlas	RB1CC1
Associated Diseases	AD, ALI, Als, Alzheimer, cancer
Known Drugs/Compounds	rapamycin
Interactions	ABCD3, ACAT1, Actin, AKT1, AKT1S1, ALS
KG Connections	1183 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RB1CC1 — AlphaFold Q8TDW5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RB1CC1 Gene

gene · 978 words

→

RB1CC1 Protein

protein · 610 words

→

Pathway Diagram

graph TD
    RB1CC1["RB1CC1"] -->|"interacts"| Dementia["Dementia"]
    RB1CC1["RB1CC1"] -->|"interacts"| Cardiovascular["Cardiovascular"]
    RB1CC1["RB1CC1"] -->|"interacts"| Als["Als"]
    RB1CC1["RB1CC1"] -->|"interacts"| Alzheimer["Alzheimer"]
    RB1CC1["RB1CC1"] -->|"interacts"| Parkinson["Parkinson"]
    RB1CC1["RB1CC1"] -->|"interacts"| Ms["Ms"]
    CAT["CAT"] -->|"interacts"| RB1CC1["RB1CC1"]
    OPTN["OPTN"] -->|"interacts"| RB1CC1["RB1CC1"]
    DNM1L["DNM1L"] -->|"interacts"| RB1CC1["RB1CC1"]
    CANX["CANX"] -->|"interacts"| RB1CC1["RB1CC1"]
    style RB1CC1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (562)

Target	Relation	Type	Str
CD19 CAR-T cell cytotoxicity	protects_against	phenotype	0.90
autophagy pathway	participates_in	pathway	0.90
Autophagy Initiation	involved_in	process	0.87
neural stem cells	activates	cell_type	0.80
neural stem cells	regulates	cell_type	0.80
SQSTM1	regulates	gene	0.80
CHCHD3	activates	gene	0.80
ubiquitin-proteasome	participates_in	pathway	0.80
RB1	regulates	gene	0.80
ELP3	interacts_with	protein	0.80
neurite growth	activates	phenotype	0.80
Autophagy	associated_with	pathway	0.80
Als	associated_with	disease	0.75
Tumor	associated_with	disease	0.75
Parkinson	associated_with	disease	0.75
autophagy	regulates	process	0.70
WIPI2	associated_with	gene	0.70
NBR1	associated_with	gene	0.70
MTOR	associated_with	gene	0.70
FIP200	encodes	protein	0.70
Apoptosis	associated_with	pathway	0.70
Toll-Like Receptor	associated_with	pathway	0.70
necroptosis	participates_in	pathway	0.70
oxidative stress response	participates_in	pathway	0.70
MAPK signaling	participates_in	pathway	0.70
RUBCNL	activates	gene	0.70
apoptosis pathway	participates_in	pathway	0.70
ROS	activates	gene	0.70
Mtor	associated_with	pathway	0.70
Parkinson's disease	activates	disease	0.70
Autophagy	inhibits	pathway	0.70
Parkinson's disease	regulates	disease	0.70
ROS	regulates	gene	0.70
AMPK signaling	participates_in	pathway	0.70
STX17	regulates	gene	0.70
TFEB	regulates	gene	0.70
SNAP29	regulates	gene	0.70
STING1	regulates	gene	0.70
ULK1	regulates	gene	0.70
Alzheimer	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Atherosclerosis	expressed_in	disease	0.65
Als	interacts_with	disease	0.65
Longevity	expressed_in	disease	0.65
Cardiovascular	expressed_in	disease	0.65
ALS	associated_with	disease	0.65

Incoming (621)

Source	Relation	Type	Str
STBD1	interacts_with	protein	0.90
lipid ROS	activates	phenotype	0.90
STBD1	binds	protein	0.90
rapamycin	targets	drug	0.80
ATG	regulates	gene	0.80
FIP200	regulates	gene	0.80
NBR1	regulates	gene	0.80
OPTN	regulates	gene	0.80
LC3	regulates	gene	0.80
MTOR	regulates	gene	0.80
RB1	associated_with	gene	0.80
LC3	associated_with	gene	0.80
CALCOCO2	associated_with	gene	0.70
OPTN	associated_with	gene	0.70
GABARAP	associated_with	gene	0.70
PRKN	associated_with	gene	0.70
SQSTM1	associated_with	gene	0.70
JNK	regulates	gene	0.70
ERN1	regulates	gene	0.70
EIF2AK3	regulates	gene	0.70
DNM1L	regulates	gene	0.70
DDIT3	regulates	gene	0.70
CALCOCO2	regulates	gene	0.70
PIK3C3	regulates	gene	0.70
GABARAP	regulates	gene	0.70
PRKN	regulates	gene	0.70
NDP52	regulates	gene	0.70
MAP1LC3B	regulates	gene	0.70
APOPTOSIS	associated_with	gene	0.70
BECN1	associated_with	gene	0.70
ATG	associated_with	gene	0.70
DNA	regulates	gene	0.70
TFEB	associated_with	gene	0.70
AMPK	regulates	gene	0.70
PARKINSON	associated_with	gene	0.70
DNA	activates	gene	0.70
GABA	regulates	gene	0.70
NLR	regulates	gene	0.70
PIK3C3	associated_with	gene	0.70
AUTOPHAGY	associated_with	gene	0.70
NLR	activates	gene	0.70
PKM2	activates	gene	0.60
LC3B	activates	gene	0.60
RAS	activates	gene	0.60
MAP1LC3	activates	gene	0.60
GSK3	activates	gene	0.60
HIF1	activates	gene	0.60
BIM	activates	gene	0.60
LC3B	regulates	gene	0.60
CREB	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RB1CC1 in their description or question text

No additional research found