gene

EPAS1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EPAS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

489Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Comprehensive page on EPAS1 gene (HIF-2α), hypoxia response in neurodegeneration, Alzheimer's disease, Parkinson's disease, and therapeutic targeting

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🧬 Gene Info

Gene Symbol	EPAS1
Full Name	Endothelial PAS Domain Protein 1
Aliases	HIF-2α
Chromosome	2p21
Protein Type	Transcription Factor
Function	is a transcription factor that serves as the master regulator of cellular responses to hypoxia.
Amino Acids	870 aa
Exons	16
Pathways	Apoptosis, MAPK signaling, Reactive Oxygen Species, apoptosis, apoptosis pathway
UniProt ID	Q9Y5Q3
NCBI Gene ID	2034
Ensembl ID	ENSG00000177640
OMIM	603349
GeneCards	EPAS1
Human Protein Atlas	EPAS1
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Interactions	ABCD3, ALS, ALZHEIMER, ALZHEIMER DISEASE, AMBRA1, AMPK
KG Connections	489 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: EPAS1 — AlphaFold Q9Y5Q3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

EPAS1 Gene

gene · 1410 words

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Pathway Diagram

graph TD
    EPAS1["EPAS1"] -->|"Interacts With"| Dementia["Dementia"]
    EPAS1["EPAS1"] -->|"Interacts With"| Cardiovascular["Cardiovascular"]
    EPAS1["EPAS1"] -->|"Interacts With"| Als["Als"]
    EPAS1["EPAS1"] -->|"Interacts With"| Alzheimer["Alzheimer"]
    EPAS1["EPAS1"] -->|"Interacts With"| Parkinson["Parkinson"]
    EPAS1["EPAS1"] -->|"Interacts With"| Ms["Ms"]
    EPAS1["EPAS1"] -->|"Interacts With"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    EPAS1["EPAS1"] -->|"Interacts With"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    CAT["CAT"] -->|"Interacts With"| EPAS1["EPAS1"]
    OPTN["OPTN"] -->|"Interacts With"| EPAS1["EPAS1"]
    DNM1L["DNM1L"] -->|"Interacts With"| EPAS1["EPAS1"]
    CANX["CANX"] -->|"Interacts With"| EPAS1["EPAS1"]
    LGALS3["LGALS3"] -->|"Interacts With"| EPAS1["EPAS1"]
    style EPAS1 fill:#8d4900,color:#e0e0e0
    style Dementia fill:#b71c1c,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Alzheimer fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Amyotrophic_Lateral_Sclerosis fill:#b71c1c,color:#e0e0e0
    style Frontotemporal_Dementia fill:#b71c1c,color:#e0e0e0
    style CAT fill:#8d4900,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style DNM1L fill:#8d4900,color:#e0e0e0
    style CANX fill:#8d4900,color:#e0e0e0
    style LGALS3 fill:#8d4900,color:#e0e0e0

Outgoing (287)

Target	Relation	Type	Str
Als	inhibits	disease	0.65
Parkinson	interacts_with	disease	0.65
Hypertension	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Ms	associated_with	disease	0.65
Asthma	inhibits	disease	0.65
Als	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
ALS	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Ftd	interacts_with	disease	0.65
Schizophrenia	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Infection	activates	disease	0.65
Viral Infection	activates	disease	0.65
Lymphoma	activates	disease	0.65
Tumor	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Autism	associated_with	disease	0.65
Obesity	associated_with	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
ALS	activates	disease	0.60
Alzheimer's disease	activates	disease	0.60
GBA	interacts_with	gene	0.60
Parkinson's disease	activates	disease	0.60
ROS	activates	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
FUNDC1	interacts_with	gene	0.60
NLR	activates	gene	0.60
NIX	activates	gene	0.60
NDP52	interacts_with	gene	0.60
HIF	activates	gene	0.60
RHOT1	interacts_with	gene	0.60
BNIP3L	interacts_with	gene	0.60
HIF1A	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
FAM134B	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
PTEN	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
dementia	associated_with	disease	0.60
Parkinson	associated_with	disease	0.60
NBR1	interacts_with	gene	0.60

Incoming (202)

Source	Relation	Type	Str
G3BP1	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
NIX	interacts_with	gene	0.60
PARKINSON	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
ALS	interacts_with	gene	0.60
CAT	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60
PGAM5	interacts_with	gene	0.60
RETREG1	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
MITOPHAGY	interacts_with	gene	0.60
HIF	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
HIF1	interacts_with	gene	0.60
RAS	interacts_with	gene	0.60
ROS	interacts_with	gene	0.60
DIABETIC RETINOPATHY	therapeutic_target	gene	0.60
EMD	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
LC3B	interacts_with	gene	0.60
GENETIC MODIFIERS	associated_with	gene	0.60
APOPTOSIS	activates	gene	0.60
ALS	activates	entity	0.60
AMPK	activates	entity	0.60
CATALASE	interacts_with	gene	0.60
PRESENILIN	interacts_with	gene	0.60
NLR	interacts_with	gene	0.60
RIP3	interacts_with	gene	0.60
SESTRIN2	interacts_with	gene	0.60
DEMENTIA	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
BIM	interacts_with	gene	0.60
ALZHEIMER DISEASE	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
ATG	activates	gene	0.60
ATP	activates	gene	0.60
BIM	activates	gene	0.60
DNA	activates	gene	0.60
NUCLEOPHAGY	interacts_with	gene	0.60
ATP	interacts_with	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
GENES	associated_with	gene	0.60
PEX3	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning EPAS1 in their description or question text

No additional research found