gene

LMNA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LMNA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

825Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

LMNA is a gene implicated in neurodegeneration research. Key relationships include: interacts with, therapeutic target, associated with. Associated with AD, ALI, ALS. Connected to 420 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	LMNA
Chromosome	1q22
Protein Type	Protein
Function	### Nuclear Lamina Structure
Primary Expression	Universal (all cell types)
Molecular Weight	72 kDa
Amino Acids	33 aa
Exons	12
Pathways	calcium_homeostasis
UniProt ID	P02545
NCBI Gene ID	3999
Ensembl ID	ENSG00000160789
OMIM	150330
GeneCards	LMNA
Human Protein Atlas	LMNA
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Interactions	A2M, ABCD3, ACETYL-COA, Actin, AGING, ALS
KG Connections	825 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: LMNA — AlphaFold P02545 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

LMNA Protein

protein · 1305 words

→

LMNA Gene

gene · 893 words

→

Pathway Diagram

graph TD
    LMNA["LMNA"] -->|"Encodes"| Lamin_AC["Lamin_AC"]
    LMNA["LMNA"] -->|"Causes"| DCM["DCM"]
    LMNA["LMNA"] -->|"Interacts With"| Alzheimer["Alzheimer"]
    LMNA["LMNA"] -->|"Interacts With"| Tumor["Tumor"]
    LMNA["LMNA"] -->|"Interacts With"| Als["Als"]
    LMNA["LMNA"] -->|"Interacts With"| Dementia["Dementia"]
    LMNA["LMNA"] -->|"Interacts With"| Cardiovascular["Cardiovascular"]
    LMNA["LMNA"] -->|"Interacts With"| Parkinson["Parkinson"]
    NCSTN["NCSTN"] -->|"Interacts With"| LMNA["LMNA"]
    FAS["FAS"] -->|"Interacts With"| LMNA["LMNA"]
    TNF["TNF"] -->|"Interacts With"| LMNA["LMNA"]
    CAT["CAT"] -->|"Interacts With"| LMNA["LMNA"]
    OPTN["OPTN"] -->|"Interacts With"| LMNA["LMNA"]
    style LMNA fill:#8d4900,color:#e0e0e0
    style Lamin_AC fill:#0d47a1,color:#e0e0e0
    style DCM fill:#b71c1c,color:#e0e0e0
    style Alzheimer fill:#b71c1c,color:#e0e0e0
    style Tumor fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Dementia fill:#b71c1c,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style NCSTN fill:#8d4900,color:#e0e0e0
    style FAS fill:#8d4900,color:#e0e0e0
    style TNF fill:#8d4900,color:#e0e0e0
    style CAT fill:#8d4900,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0

Outgoing (469)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:LMNA	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Progerin	associated_with	protein	0.95
NEURODEGENERATIVE DISEASES	involved_in	disease	0.85
Lamin_AC	encodes	protein	0.80
Nuclear Export	involved_in	process	0.80
Tumor	interacts_with	disease	0.75
DCM	causes	disease	0.72
DNA	interacts_with	gene	0.70
OPTN	interacts_with	gene	0.70
Cardiomyopathy	causes	disease	0.65
Cardiac	associated_with	disease	0.65
Ms	activates	disease	0.65
Senescence	expressed_in	disease	0.65
ALZHEIMER'S DISEASE	associated_with	entity	0.65
Cancer	expressed_in	disease	0.65
Inflammation	associated_with	disease	0.65
Senescence	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Cardiac	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Heart Failure	associated_with	disease	0.65
Aging	regulates	disease	0.65
Cancer	regulates	disease	0.65
Tumor	regulates	disease	0.65
Heart Failure	therapeutic_target	disease	0.65
Fibrosis	associated_with	disease	0.65
Senescence	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Cancer	associated_with	disease	0.65
Cardiac	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Aging	expressed_in	disease	0.65
Aging	interacts_with	disease	0.65
Huntington	interacts_with	disease	0.65
Senescence	interacts_with	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Obesity	therapeutic_target	disease	0.65
Ms	interacts_with	disease	0.65
Als	regulates	disease	0.65
ALS	regulates	disease	0.65
Tumor	associated_with	disease	0.65
Aging	activates	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Melanoma	interacts_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65

Incoming (356)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:LMNA	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
AUTOPHAGY	interacts_with	gene	0.60
FUNDC1	regulates	gene	0.60
DNA	interacts_with	gene	0.60
HIF1	interacts_with	gene	0.60
BNIP3	regulates	gene	0.60
AMBRA1	regulates	gene	0.60
DDIT3	regulates	gene	0.60
FIP200	regulates	gene	0.60
JNK	regulates	gene	0.60
LGALS3	regulates	gene	0.60
MITOCHONDRIAL DNA	interacts_with	gene	0.60
NIX	interacts_with	gene	0.60
HRAS	therapeutic_target	gene	0.60
NPM1	interacts_with	gene	0.60
BCL2	regulates	gene	0.60
BECN1	regulates	gene	0.60
CAT	regulates	gene	0.60
CTSD	regulates	gene	0.60
DNM1L	regulates	gene	0.60
ERN1	regulates	gene	0.60
GBA	regulates	gene	0.60
HIF1A	regulates	gene	0.60
PRDX1	interacts_with	gene	0.60
LC3	regulates	gene	0.60
ARHGEF2	interacts_with	gene	0.60
EMD	activates	entity	0.60
TPM3	interacts_with	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
DISC1	activates	entity	0.60
ATM	regulates	gene	0.60
PHB2	interacts_with	gene	0.60
LC3B	interacts_with	gene	0.60
DRD2	therapeutic_target	gene	0.60
A2M	interacts_with	gene	0.60
NCOA4	interacts_with	gene	0.60
BCL2L13	regulates	gene	0.60
IDH2	therapeutic_target	gene	0.60
CALCOCO2	regulates	gene	0.60
CDKN2A	interacts_with	gene	0.60
CHOP	regulates	gene	0.60
EPAS1	activates	entity	0.60
DISC1	regulates	gene	0.60
DRP1	regulates	gene	0.60
EIF2AK3	regulates	gene	0.60
CARDIOMYOPATHY	associated_with	entity	0.60
MYO5A	interacts_with	gene	0.60
RET	interacts_with	gene	0.60
BNIP3L	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LMNA in their description or question text

No additional research found