gene

HSPA5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSPA5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

489Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for HSPA5 — Heat Shock Protein Family A (Hsp70) Member 5

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🧬 Gene Info

Gene Symbol	HSPA5 / GRP78 / BiP
Full Name	Heat Shock Protein Family A (Hsp70) Member 5
Aliases	Hsp70
Chromosome	9q33.3
Protein Family	Hsp70 family (ER-resident)
Protein Type	Chaperone
Function	HSPA5/GRP78 is a BiP (Binding Immunoglobulin Protein) that resides in the ER lumen.
Primary Expression	brain, particularly in neurons and glia
Pathways	Akt, Autophagy, Lipid Metabolism, Wnt
UniProt ID	P11021
NCBI Gene ID	3309
Ensembl ID	ENSG00000156006
OMIM	138120
Location	Chromosome 9q33.3
Protein	HSPA5/GRP78/BiP
Associated Diseases	Aging, Atherosclerosis, Diabetes
Known Drugs/Compounds	rapamycin
Interactions	ACETYL-COA, AKT, AKT1, AKT1S1, AMBRA1, AMPK
KG Connections	489 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HSPA5 — AlphaFold P11021 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

HSPA5 — Heat Shock Protein Family A (Hsp70) Member 5

gene · 802 words

→

HSPA5/BiP Protein

protein · 1184 words

→

Pathway Diagram

graph TD
    HSPA5["HSPA5"] -->|"Interacts With"| Cancer["Cancer"]
    HSPA5["HSPA5"] -->|"Interacts With"| Als["Als"]
    HSPA5["HSPA5"] -->|"Interacts With"| Ms["Ms"]
    HSPA5["HSPA5"] -->|"Interacts With"| Fibrosis["Fibrosis"]
    HSPA5["HSPA5"] -->|"Activates"| Arthritis["Arthritis"]
    HSPA5["HSPA5"] -->|"Interacts With"| MAVS["MAVS"]
    HSPA5["HSPA5"] -->|"Interacts With"| FIP200["FIP200"]
    HSPA5["HSPA5"] -->|"Interacts With"| AMBRA1["AMBRA1"]
    OPTN["OPTN"] -->|"Interacts With"| HSPA5["HSPA5"]
    CASP3["CASP3"] -->|"Interacts With"| HSPA5["HSPA5"]
    AKT1["AKT1"] -->|"Interacts With"| HSPA5["HSPA5"]
    CALCOCO2["CALCOCO2"] -->|"Interacts With"| HSPA5["HSPA5"]
    CGAS["CGAS"] -->|"Interacts With"| HSPA5["HSPA5"]
    style HSPA5 fill:#8d4900,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Fibrosis fill:#b71c1c,color:#e0e0e0
    style Arthritis fill:#b71c1c,color:#e0e0e0
    style MAVS fill:#8d4900,color:#e0e0e0
    style FIP200 fill:#8d4900,color:#e0e0e0
    style AMBRA1 fill:#8d4900,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style CASP3 fill:#8d4900,color:#e0e0e0
    style AKT1 fill:#8d4900,color:#e0e0e0
    style CALCOCO2 fill:#8d4900,color:#e0e0e0
    style CGAS fill:#8d4900,color:#e0e0e0

Outgoing (293)

Target	Relation	Type	Str
ER STRESS	mediates	entity	0.90
ROS	inhibits	entity	0.85
ERK	regulates	entity	0.85
APOPTOSIS	inhibits	entity	0.85
Endoplasmic Reticulum Stress	biomarker_for	process	0.85
OXIDATIVE STRESS	inhibits	entity	0.85
EPITHELIUM	expressed_in	entity	0.85
JNK	regulates	entity	0.85
THERAPEUTIC_TARGET	therapeutic_target	entity	0.80
MAPK	regulates	entity	0.80
NEUROINFLAMMATION	mediates	entity	0.70
NEURODEGENERATION	implicated_in	entity	0.70
ER STRESS	regulates	entity	0.70
OXIDATIVE STRESS	modulates	entity	0.70
APOPTOSIS	regulates	entity	0.70
CANCER	implicated_in	entity	0.70
Hypertension	expressed_in	disease	0.65
Als	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	regulates	disease	0.65
ALS	interacts_with	disease	0.65
Tumor	inhibits	disease	0.65
Ovarian Cancer	regulates	disease	0.65
Als	inhibits	disease	0.65
Aging	associated_with	disease	0.65
Ms	inhibits	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Ms	activates	disease	0.65
Diabetes	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	interacts_with	disease	0.65
Fibrosis	interacts_with	disease	0.65
Arthritis	activates	disease	0.65
Fibrosis	regulates	disease	0.65
ALS	activates	disease	0.65
Osteoarthritis	activates	disease	0.65
Als	regulates	disease	0.65
Ras	activates	protein	0.60
IFN	activates	gene	0.60
NLR	activates	gene	0.60
NRBF2	activates	gene	0.60
ROS	activates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
necroptosis	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
MAPK signaling	participates_in	pathway	0.60

Incoming (196)

Source	Relation	Type	Str
DTG	upregulates	entity	0.90
Endoplasmic Reticulum Stress	upregulates	process	0.90
KDEL	interacts_with	protein	0.85
DDIT3	upregulates	gene	0.80
TFEB	upregulates	entity	0.75
DEPTOR	interacts_with	gene	0.60
HMGB1	interacts_with	gene	0.60
EGF	interacts_with	gene	0.60
MLST8	interacts_with	gene	0.60
RICTOR	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
PIK3C3	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60
PPARG	interacts_with	gene	0.60
RAB7A	therapeutic_target	gene	0.60
IGF2R	therapeutic_target	gene	0.60
CAPZB	therapeutic_target	gene	0.60
RAB5A	therapeutic_target	gene	0.60
HSPA1A	therapeutic_target	gene	0.60
RAB8A	therapeutic_target	gene	0.60
CANX	therapeutic_target	gene	0.60
DDIT3	phosphorylates	entity	0.60
DEPTOR	phosphorylates	entity	0.60
EGF	phosphorylates	entity	0.60
EGFR	phosphorylates	entity	0.60
EIF2A	phosphorylates	entity	0.60
EIF2AK3	phosphorylates	entity	0.60
ERN1	phosphorylates	entity	0.60
FIP200	phosphorylates	entity	0.60
GABARAP	phosphorylates	entity	0.60
GRB2	phosphorylates	entity	0.60
HMGB1	phosphorylates	entity	0.60
HSP70	phosphorylates	entity	0.60
HK2	regulates	gene	0.60
MITOPHAGY	associated_with	gene	0.60
DIABETES MELLITUS	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
AUTOPHAGY-RELATED GENES	associated_with	gene	0.60
RAS	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
ATP	interacts_with	gene	0.60
MLKL	interacts_with	gene	0.60
IFN	interacts_with	gene	0.60
CASP3	interacts_with	gene	0.60
AKT1	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
CGAS	interacts_with	gene	0.60
CFTR	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity