protein

IRE1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IRE1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

225Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

IRE1 is a protein involved in neurodegeneration research. Key relationships include: activates, implicated in, expressed in. Associated with ALS. Connected to 23 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	IRE1
Function	Inositol-requiring enzyme 1 (IRE1) is the most evolutionarily conserved sensor of the unfolded protein response (UPR)
Molecular Weight	110 kDa
Pathways	Endoplasmic Reticulum Stress
GeneCards	IRE1
Human Protein Atlas	IRE1
Associated Diseases	Cardiovascular, Diabetes, Neurodegeneration
Known Drugs/Compounds	Dolutegravir, DTG, rapamycin
Interactions	AND, APOPTOSIS, ATF4, ATF6, ATG, AUTOPHAGY
KG Connections	225 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    IRE1["IRE1"]
    ALS{"ALS"}
    IRE1 -->|"activates"| ALS
    IL6["IL6"]
    IRE1 -->|"activates"| IL6
    CXCL1["CXCL1"]
    IRE1 -->|"activates"| CXCL1
    Blood_Brain_Barrier(["Blood-Brain Barrier"])
    IRE1 -->|"activates"| Blood_Brain_Barrier
    Er_Stress(["Er Stress"])
    IRE1 -->|"activates"| Er_Stress
    ATF4["ATF4"]
    IRE1 -->|"activates"| ATF4
    PPP1R15A["PPP1R15A"]
    IRE1 -->|"activates"| PPP1R15A
    Endothelial_Cell["Endothelial Cell"]
    IRE1 -->|"expressed in"| Endothelial_Cell
    neurodegeneration["neurodegeneration"]
    IRE1 -->|"implicated in"| neurodegeneration
    Dolutegravir["Dolutegravir"]
    Dolutegravir -->|"activates"| IRE1
    XBP1["XBP1"]
    XBP1 -->|"activates"| IRE1
    ATF4 -->|"activates"| IRE1
    HSPA5["HSPA5"]
    HSPA5 -->|"activates"| IRE1
    CXCL2["CXCL2"]
    CXCL2 -->|"activates"| IRE1
    CLDN5["CLDN5"]
    CLDN5 -->|"activates"| IRE1
    IL23A["IL23A"]
    IL23A -->|"activates"| IRE1
    PERK["PERK"]
    PERK -->|"activates"| IRE1
    PPP1R15A -->|"activates"| IRE1
    DDIT3["DDIT3"]
    DDIT3 -->|"activates"| IRE1
    IL12B["IL12B"]
    IL12B -->|"activates"| IRE1
    CYTOKINES["CYTOKINES"]
    CYTOKINES -->|"activates"| IRE1
    style IRE1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (132)

Target	Relation	Type	Str
Endoplasmic Reticulum Stress	mediates	process	0.90
JNK	activates	pathway	0.88
Endoplasmic Reticulum Stress	involved_in	process	0.85
Obesity	activates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Pyroptosis	activates	disease	0.65
Diabetes	activates	disease	0.65
Cancer	protects_against	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
ALS	activates	disease	0.65
Blood-Brain Barrier	therapeutic_target	pathway	0.60
XBP1	expressed_in	gene	0.60
Blood-Brain Barrier	activates	pathway	0.60
Er Stress	activates	pathway	0.60
XBP1	associated_with	gene	0.60
PERK	expressed_in	gene	0.60
Erk	activates	protein	0.60
App	therapeutic_target	protein	0.60
ATF4	activates	gene	0.60
PPP1R15A	activates	gene	0.60
JNK	regulates	gene	0.60
PERK	regulates	gene	0.60
DDIT3	activates	gene	0.60
OCLN	activates	gene	0.60
AND	activates	gene	0.60
RNA	activates	gene	0.60
MAPK signaling	participates_in	pathway	0.60
apoptosis pathway	participates_in	pathway	0.60
ER stress	activates	process	0.60
autophagy pathway	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
ferroptosis	participates_in	pathway	0.60
CXCL2	activates	gene	0.60
HSPA5	activates	gene	0.60
IL23A	activates	gene	0.60
CLDN5	activates	gene	0.60
CYTOKINES	activates	gene	0.60
IL12B	activates	gene	0.60
PERK	associated_with	gene	0.60
LAMP1	activates	gene	0.60
MTOR	activates	gene	0.60
RBFOX3	activates	gene	0.60
WDR45	activates	gene	0.60
neurodegeneration	activates	disease	0.60
Er Stress	associated_with	pathway	0.60
Endothelial	therapeutic_target	cell_type	0.60
Apoptosis	activates	pathway	0.60

Incoming (93)

Source	Relation	Type	Str
Dolutegravir	activates	drug	0.92
DTG	activates	drug	0.90
HSPA5	activates	gene	0.60
CXCL2	activates	gene	0.60
CLDN5	activates	gene	0.60
IL23A	activates	gene	0.60
PERK	activates	gene	0.60
PPP1R15A	activates	gene	0.60
DDIT3	activates	gene	0.60
IL12B	activates	gene	0.60
OCLN	activates	gene	0.60
IL6	activates	gene	0.60
CLDN5	therapeutic_target	gene	0.60
AND	activates	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
XBP1	activates	gene	0.60
ATF4	activates	gene	0.60
rapamycin	targets	drug	0.60
NLRP3	activates	gene	0.60
GPX4	activates	gene	0.60
PYROPTOSIS	activates	gene	0.60
ATG	activates	gene	0.60
GFP	activates	gene	0.60
PPARGC1A	inhibits	gene	0.60
IL6	therapeutic_target	gene	0.60
IL12B	therapeutic_target	gene	0.60
CXCL1	therapeutic_target	gene	0.60
OCLN	therapeutic_target	gene	0.60
CXCL2	therapeutic_target	gene	0.60
IL23A	therapeutic_target	gene	0.60
ATF4	associated_with	gene	0.60
CHOP	associated_with	gene	0.60
ATF4	expressed_in	gene	0.60
DNA	activates	gene	0.60
COX2	activates	gene	0.60
EIF2AK3	associated_with	gene	0.60
ERN1	associated_with	gene	0.60
ATF6	activates	gene	0.60
CHOP	activates	gene	0.60
EIF2A	activates	gene	0.60
EIF2AK3	activates	gene	0.60
ERN1	activates	gene	0.60
HSP70	activates	gene	0.60
CYTOKINES	activates	gene	0.60
JNK	regulates	gene	0.60
PERK	regulates	gene	0.60
RAGE	associated_with	gene	0.60
NRF2	associated_with	gene	0.60
RNA	activates	gene	0.60
EIF2Α	activates	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IRE1 in their description or question text

No additional research found