gene

CTSD

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CTSD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1555Connections

0Hypotheses

4Analyses

50Outgoing

50Incoming

0Experiments

6Debates

Summary

CTSD is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, regulates. Associated with AD, ADH, ALI. Connected to 651 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CTSD
Full Name	Cathepsin D
Aliases	CPSD, CLN10
Chromosome	11p15.5
Protein Type	Protease
Function	is a lysosomal aspartic protease encoded by the CTSD gene.
Primary Expression	Brain, liver, macrophages, neurons, microglia
Molecular Weight	48 kDa
Pathways	Akt, Angiogenesis, Apoptosis, Autophagy, Blood-Brain Barrier
UniProt ID	P07339
NCBI Gene ID	1509
Ensembl ID	ENSG00000103811
GeneCards	CTSD
Human Protein Atlas	CTSD
Pre-proenzyme	Signal peptide + prosegment + mature enzyme
Associated Diseases	AD, ADH, Aging, ALI, Als
Known Drugs/Compounds	CHLOROQUINE, COENZYME Q10, H2S, rapamycin, RAPAMYCIN
Interactions	ABCA1, ABCD3, ACTB, Actin, ADRA2A, AGING
KG Connections	1555 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CTSD — AlphaFold P07339 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CTSD["CTSD"] -->|"activates"| Metabolic_Syndrome["Metabolic Syndrome"]
    CTSD["CTSD"] -->|"regulates"| Ischemia["Ischemia"]
    CTSD["CTSD"] -->|"regulates"| Ms["Ms"]
    CTSD["CTSD"] -->|"interacts"| Dementia["Dementia"]
    CTSD["CTSD"] -->|"interacts"| Cardiovascular["Cardiovascular"]
    CTSD["CTSD"] -->|"interacts"| Als["Als"]
    ACTB["ACTB"] -->|"regulates"| CTSD["CTSD"]
    PPARA["PPARA"] -->|"regulates"| CTSD["CTSD"]
    CAT["CAT"] -->|"regulates"| CTSD["CTSD"]
    SQSTM1["SQSTM1"] -->|"regulates"| CTSD["CTSD"]
    style CTSD fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (987)

Target	Relation	Type	Str
lysosomal_degradation	catalyzes	pathway	0.00
Amyloid fibril fragmentation	mediates	process	0.95
neural stem cells	activates	cell_type	0.90
Neuronal ceroid lipofuscinosis	causes	disease	0.90
Lysosomal Function	regulates	process	0.90
Autophagy	associated_with	process	0.90
HSP90α	inhibits	protein	0.90
CLN10	associated_with	disease	0.90
CLN10	causes	disease	0.90
neuronal ceroid lipofuscinosis	causes	disease	0.90
Amyloid propagation	contributes_to	process	0.87
Alpha-Synuclein Neurotoxicity	modulates	phenotype	0.85
proteostasis	modulates	pathway	0.80
lysosome	part_of	cell_type	0.80
autophagy	part_of	pathway	0.80
neural stem cells	regulates	cell_type	0.80
Apoptosis	modulates	process	0.80
neuronal ceroid lipofuscinosis	associated_with	disease	0.80
lysosomal-autophagy machinery	part_of	pathway	0.80
Cell Proliferation	modulates	process	0.80
Parkinson's disease	contributes_to	disease	0.80
α-synuclein neurotoxicity	modulates	phenotype	0.80
Alzheimer	associated_with	disease	0.75
Als	associated_with	disease	0.75
Dementia	associated_with	disease	0.75
Neuroinflammation	involved_in	process	0.75
Aging	associated_with	disease	0.75
LPL	associated_with	gene	0.70
SNCA	regulates	protein	0.70
autophagy	enhances	pathway	0.70
autophagy	regulates	process	0.70
SNCA aggregates	inhibits	protein	0.70
phagocytosis	part_of	pathway	0.70
endocytosis	part_of	pathway	0.70
Complement	associated_with	pathway	0.70
atherosclerosis	associated_with	disease	0.70
osteoporosis	associated_with	disease	0.70
Parkinson disease	associated_with	disease	0.70
Alzheimer's disease	interacts_with	disease	0.70
SNCA	targets	protein	0.70
GFP	activates	gene	0.70
oxidative stress response	participates_in	pathway	0.70
GFP	interacts_with	gene	0.70
Parkinson's disease	activates	disease	0.70
Autophagy	inhibits	pathway	0.70
Alzheimer's disease	activates	disease	0.70
MCOLN1	interacts_with	gene	0.70
MCOLN1	activates	gene	0.70
ULK1	interacts_with	gene	0.70
LC3B	regulates	gene	0.70

Incoming (568)

Source	Relation	Type	Str
lnc-HIBADH-4	regulates	biomarker	0.85
rapamycin	targets	drug	0.80
LRP6	interacts_with	protein	0.80
SLAMF7	inhibits	gene	0.80
LRP6	activates	protein	0.80
ATG	activates	gene	0.80
AMPK	regulates	gene	0.70
ATP	activates	gene	0.70
TNF	associated_with	gene	0.70
GENES	associated_with	gene	0.70
BECN1	regulates	gene	0.70
APOE	inhibits	gene	0.70
CTSB	interacts_with	gene	0.70
PRESENILIN	associated_with	gene	0.70
AMBRA1	regulates	gene	0.70
BCL2	regulates	gene	0.70
CERAMIDE	regulates	phenotype	0.65
CANCER	targets	disease	0.65
MICROGLIA	regulates	cell_type	0.65
TFEB	mediates	gene	0.65
CLU	co_discussed	gene	0.65
BDNF	co_discussed	gene	0.65
MTOR	phosphorylates	gene	0.65
CHLOROQUINE	activates	drug	0.65
CR1	co_discussed	gene	0.65
APOE	co_discussed	gene	0.65
SREBF1	regulates	gene	0.60
CALCOCO2	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
RAB7A	regulates	gene	0.60
CAT	regulates	gene	0.60
CANX	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
SNCAIP	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
ULK1	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
RAB9A	associated_with	gene	0.60
BCL2L1	associated_with	gene	0.60
GLA	associated_with	gene	0.60
DNM1L	interacts_with	gene	0.60
RPS6KB1	regulates	gene	0.60
STING1	interacts_with	gene	0.60
MTOR	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (4)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (6)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning CTSD in their description or question text

No additional research found

CTSD

Understanding Entity Pages

Summary

Wiki Pages (7)

CTSD — Cathepsin D

CTSD Gene - Cathepsin D

CTSD — Cathepsin D

CTSD (Cathepsin D)

Cathepsin D (CTSD)

CTSD Protein - Cathepsin D

Pathway Diagram

Outgoing (987)

Incoming (568)

Targeting Hypotheses (0)

Mentioning Analyses (4)

Neuroinflammation and microglial priming in early AD

Tau propagation mechanisms and therapeutic interception points

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas

Experiments (0)

Related Papers (0)

Debates (6)

Investigate prion-like spreading of tau pathology through connected brain region

How does microglial priming contribute to early Alzheimer's disease pathology? F

Neuroinflammation and microglial priming in early AD

Tau propagation mechanisms and therapeutic interception points

What cell types are most vulnerable in Alzheimers Disease based on SEA-AD transc

Cell-type specific expression patterns of neurodegeneration genes in SEA-AD

Related Research