AUTOPHAGY

While the study establishes LRRK2 as a lysosomal swelling sensor and notes that

closed · Rounds: 4 · Score: 0.85 · 2026-04-16

Do tau-containing vesicles exhibit unique surface glycosylation patterns that di

closed · Rounds: 4 · Score: 0.95 · 2026-04-10

The debate highlighted TFEB's role in mitochondrial-lysosomal coupling but could

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

What are the mechanisms underlying protein aggregation cross-seeding across neur

closed · Rounds: 4 · Score: 0.95 · 2026-04-01

Closed-loop tACS targeting entorhinal cortex layer II SST interneurons to activa

Score: 0.784 · Alzheimer's disease · 2026-04-05

## Mechanistic Overview Closed-loop tACS targeting entorhinal cortex layer II SST interneurons to activate AMPK-autophag

TBK1-OPTN-NDP52 Phospho-Cascade Coordinates Multi-Organelle Autophagy

Score: 0.772 · neurodegeneration · 2026-04-21

## Mechanistic Overview TBK1-OPTN-NDP52 Phospho-Cascade Coordinates Multi-Organelle Autophagy starts from the claim that

Circadian Clock-Autophagy Synchronization

Score: 0.763 · neurodegeneration · 2026-04-02

## Mechanistic Overview Circadian Clock-Autophagy Synchronization starts from the claim that modulating CLOCK within the

H2: Impaired Autophagy Receptor Recruitment Traps G3BP1 Granules

Score: 0.737 · neurodegeneration · 2026-04-22

**Molecular Mechanism and Rationale** The central molecular mechanism underlying this hypothesis involves the intricate

VCP/p97 ATPase mutations impair extraction of ubiquitinated autophagy substrates

Score: 0.720 · neurodegeneration · 2026-04-21

## Mechanistic Overview VCP/p97 ATPase mutations impair extraction of ubiquitinated autophagy substrates, causing protea

C9orf72 DPRs Impair Autophagy Receptor Docking on Stress Granules

Score: 0.717 · neurodegeneration · 2026-04-22

## **Molecular Mechanism and Rationale** The hexanucleotide repeat expansion (GGGGCC) in the C9orf72 gene represents th

p21^Cip1 Phospho-State as Autophagy Responsiveness Predictor

Score: 0.710 · molecular biology · 2026-04-21

**Molecular Mechanism and Rationale** The p21^Cip1 protein, encoded by the CDKN1A gene, functions as a critical molecul

Autophagy-Lysosomal Degradation of IBA1 in Stressed Microglia

Score: 0.706 · neuroinflammation · 2026-04-21

## Mechanistic Overview Autophagy-Lysosomal Degradation of IBA1 in Stressed Microglia starts from the claim that modulat

TFEB-Independent Autophagy Bypass

Score: 0.697 · neurodegeneration · 2026-04-04

## Mechanistic Overview TFEB-Independent Autophagy Bypass starts from the claim that modulating ULK1 within the disease

mTORC1 Reactivation as Autophagy-Senescence Divergence Point Marker

Score: 0.685 · molecular biology · 2026-04-21

## Mechanistic Overview mTORC1 Reactivation as Autophagy-Senescence Divergence Point Marker starts from the claim that m

TDP-43 Pathology Disrupts the HGS-PYGB Autophagy Receptor Cascade in Motor Neuro

Score: 0.678 · neurodegeneration · 2026-04-26

TDP-43 aggregates sequester hepatocyte growth factor-regulated tyrosine kinase substrate (HGS), a critical hub coordinat

GDF15-GFRAL Axis as Systemic Autophagy-Senescence Integrator

Score: 0.653 · molecular biology · 2026-04-21

## Mechanistic Overview GDF15-GFRAL Axis as Systemic Autophagy-Senescence Integrator starts from the claim that modulati

Radiation drives pericyte senescence through lysosome acidification failure and

Score: 0.652 · neurodegeneration · 2026-04-25

Autophagosomes still form after irradiation, but damaged lysosomes cannot clear cargo, sustaining ROS and SASP output.

p62 Liquid-Liquid Phase Separation Nucleates Cross-Organelle Cargo for Coordinat

Score: 0.649 · neurodegeneration · 2026-04-21

## Mechanistic Overview p62 Liquid-Liquid Phase Separation Nucleates Cross-Organelle Cargo for Coordinated Autophagy sta

H7: mTOR Hyperactivity Blocks Autophagy, Permitting Tau Seeding

Score: 0.640 · neurodegeneration · 2026-04-22

**Molecular Mechanism and Rationale** The mechanistic target of rapamycin complex 1 (mTORC1) serves as a critical cellu