protein

LC3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LC3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3247Connections

1Hypotheses

5Analyses

50Outgoing

50Incoming

0Experiments

7Debates

Summary

Page for LC3 (Microtubule-Associated Protein 1 Light Chain 3)

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🔬 Protein Info

Gene Symbol	LC3
Aliases	Microtubule-Associated Protein 1 Light Chain 3
Protein Type	Transcription Factor
Function	LC3 is essential for autophagosome formation and function
Molecular Weight	17 kDa
Pathways	Akt, Apoptosis, Autophagy, Camp Signaling, Cell Cycle
GeneCards	LC3
Human Protein Atlas	LC3
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	ATTECs, CISPLATIN, dimethyl fumarate, licorice, nicotinamide, rapamycin
Interactions	6-OHDA, ABCA1, ABCD3, ABCG1, ABP, ACAT1
KG Connections	3246 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    LC3["LC3"] -.->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    LC3["LC3"] <-->|"interacts with"| Als["Als"]
    LC3["LC3"] <-->|"interacts with"| Amyotrophic_Lateral_Scler["Amyotrophic Lateral Sclerosis"]
    LC3["LC3"] <-->|"interacts with"| Dementia["Dementia"]
    LC3["LC3"] <-->|"interacts with"| Cardiovascular["Cardiovascular"]
    LC3["LC3"] <-->|"interacts with"| Alzheimer["Alzheimer"]
    LC3["LC3"] <-->|"interacts with"| Parkinson["Parkinson"]
    LC3["LC3"] <-->|"interacts with"| Ms["Ms"]
    LC3["LC3"] <-->|"interacts with"| Cancer["Cancer"]
    LC3["LC3"] <-->|"interacts with"| Fibrosis["Fibrosis"]
    LC3["LC3"] ---|"associated with"| Glioblastoma["Glioblastoma"]
    LC3["LC3"] ---|"associated with"| Tumor["Tumor"]
    style LC3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0
    style Atherosclerosis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Amyotrophic_Lateral_Scler fill:#ef5350,stroke:#333,color:#e0e0e0
    style Dementia fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cardiovascular fill:#ef5350,stroke:#333,color:#e0e0e0
    style Alzheimer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Parkinson fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Fibrosis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Glioblastoma fill:#ef5350,stroke:#333,color:#e0e0e0
    style Tumor fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (1836)

Target	Relation	Type	Str
LC3	encodes	protein	0.00
MTOR	activates	gene	1.00
MTOR	associated_with	gene	1.00
MITOPHAGY	associated_with	gene	1.00
MITOCHONDRIA	activates	gene	1.00
Infection	activates	disease	1.00
Autophagy	activates	pathway	1.00
Inflammation	activates	disease	1.00
Autophagy	inhibits	pathway	1.00
Phagocytosis	associated_with	pathway	1.00
PHAGOCYTOSIS	associated_with	gene	1.00
Pi3K/Akt	activates	pathway	1.00
Cancer	therapeutic_target	disease	1.00
CANCER	activates	gene	1.00
Mitophagy	activates	pathway	1.00
Neurodegeneration	activates	disease	1.00
Als	regulates	disease	1.00
Apoptosis	activates	pathway	1.00
Als	inhibits	disease	1.00
Tumor	activates	disease	1.00
Cancer	associated_with	disease	1.00
Cancer	activates	disease	1.00
MITOCHONDRIA	interacts_with	gene	1.00
autophagy	regulates	process	1.00
Als	interacts_with	disease	1.00
Mtor	associated_with	pathway	1.00
Oxidative Stress	activates	pathway	1.00
Mtor	inhibits	pathway	1.00
Aging	activates	disease	1.00
Cancer	inhibits	disease	1.00
AUTOPHAGY	activates	gene	1.00
AKT	activates	gene	1.00
Autophagy	regulates	pathway	1.00
Mtor	activates	pathway	1.00
Als	activates	disease	1.00
ALZHEIMER'S DISEASE	activates	gene	1.00
ULK1	activates	gene	1.00
Autophagy	associated_with	pathway	1.00
P62	activates	gene	1.00
Alzheimer	activates	disease	1.00
Als	associated_with	disease	1.00
Autophagy	interacts_with	pathway	1.00
Tumor	associated_with	disease	1.00
SQSTM1	activates	gene	1.00
MTOR	inhibits	gene	1.00
AUTOPHAGY	associated_with	gene	1.00
Tumor	inhibits	disease	1.00
LC3B	activates	gene	1.00
GENES	activates	gene	1.00
AKT	inhibits	gene	1.00

Incoming (1411)

Source	Relation	Type	Str
LC3	encodes	gene	0.00
MAP1LC3	activates	gene	1.00
AUTOPHAGY	associated_with	gene	1.00
ROS	activates	gene	1.00
ATG	interacts_with	gene	1.00
PI3K	activates	gene	1.00
GFP	associated_with	gene	1.00
NEURODEGENERATION	activates	gene	1.00
P62	activates	gene	1.00
ATG5	activates	gene	1.00
AUTOPHAGY	inhibits	gene	1.00
INFLAMMATION	activates	gene	1.00
MITOPHAGY	activates	gene	1.00
OXIDATIVE STRESS	activates	gene	1.00
ATG7	activates	gene	1.00
ALZHEIMER	activates	gene	1.00
AUTOPHAGY	activates	gene	1.00
P62	interacts_with	gene	1.00
BECLIN1	activates	gene	1.00
MITOPHAGY	interacts_with	gene	1.00
P62	regulates	gene	1.00
CANCER	activates	gene	1.00
SQSTM1	activates	gene	1.00
ATG5	associated_with	gene	1.00
TNF	activates	gene	1.00
ATG8	interacts_with	gene	1.00
PINK1	activates	gene	1.00
MAP1LC3	associated_with	gene	1.00
BAX	activates	gene	1.00
ALZHEIMER'S DISEASE	associated_with	disease	0.98
APOPTOSIS	associated_with	gene	0.98
BECN1	activates	gene	0.98
CD274	interacts_with	protein	0.95
L1CAM	interacts_with	protein	0.95
TFAM LIR motif	binds_to	protein_domain	0.95
TGM2	associated_with	entity	0.95
TDP43	regulates	entity	0.92
p62/SQSTM1	binds	protein	0.90
BECN1	upregulates	entity	0.90
AKT	associated_with	gene	0.90
paeoniflorin	contributes_to	drug	0.90
ginseng root extract	contributes_to	drug	0.90
TFEB	regulates	protein	0.90
TRIAD3A	regulates	gene	0.90
AUTOPHAGY	regulates	gene	0.90
TRIAD3A	binds	gene	0.90
AMPK	activates	gene	0.90
mTOR	upstream_of	pathway	0.90
ALS	activates	disease	0.90
SQSTM1	associated_with	gene	0.90

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
PINK1/PARK2-LC3 Mitophagy Enhancement	0.485	Neuroinflammation	Immune atlas neuroinflammation analysis

Mentioning Analyses (5)

Scientific analyses that reference this entity

Tau propagation mechanisms and therapeutic interception points

neurodegeneration | 2026-04-04 | 15 hypotheses Top: 0.814

Sleep disruption as cause and consequence of neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.763

Senolytic therapy for age-related neurodegeneration

neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.782

Autophagy-lysosome pathway convergence across neurodegenerative diseases

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.757

Mechanistic role of APOE in neurodegeneration

neurodegeneration | 2026-04-01 | 5 hypotheses Top: 0.742

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (7)

Multi-agent debates referencing this entity

Hypothesis debate: SASP-Mediated Complement Cascade Amplification

closed · Rounds: 4 · Score: 0.40 · 2026-04-27

Investigate prion-like spreading of tau pathology through connected brain region

closed · Rounds: 4 · Score: 0.90 · 2026-04-12

Multiple NDDs converge on autophagy-lysosome dysfunction. Are there universal th

closed · Rounds: 4 · Score: 0.90 · 2026-04-06

Senolytics targeting p16/p21+ senescent astrocytes and microglia may reduce SASP

closed · Rounds: 4 · Score: 0.89 · 2026-04-06

Analysis question not specified

closed · Rounds: 4 · Score: 0.87 · 2026-04-06

Sleep disruption as cause and consequence of neurodegeneration

closed · Rounds: 4 · Score: 0.91 · 2026-04-06

Tau propagation mechanisms and therapeutic interception points

closed · Rounds: 3 · Score: 0.95 · 2026-04-04

Related Research

Hypotheses and analyses mentioning LC3 in their description or question text

No additional research found

LC3

Understanding Entity Pages

Summary

Wiki Pages (21)

MAP1LC3A Gene

SLC30A3 — Solute Carrier Family 30 Member 3 (ZnT3)

MAP1LC3A Gene

SLC39A4 (ZIP4)

SLC39A1 — Solute Carrier Family 39 Member 1

SLC39A12 — Solute Carrier Family 39 Member 12 (ZIP12)

SLC30A5 — Solute Carrier Family 3 Member 0A5 (SLC30A5)

SLC39A6 — Solute Carrier Family 39 Member 6

SLC30A1

SLC39A14 — Solute Carrier Family 39 Member 14 (Zip14)

SLC34A3 — Sodium-Phosphate Transporter 3

SLC3A1 — Solute Carrier Family 3 Member 1

SLC39A9 Gene

MAP1LC3B — LC3B

SLC39A10 — Solute Carrier Family 39 Member 10

SLC39A13 — Solute Carrier Family 39 Member 13

LC3 (MAP1LC3) Neurons

MAP1LC3B2 Protein

SLC39A3 — Solute Carrier Family 39 Member 3

SLC31A1 — Solute Carrier Family 3 Member 1A1 (SLC31A1)

SLC30A10 - Zinc Transporter 10

Pathway Diagram

Outgoing (1836)

Incoming (1411)

Targeting Hypotheses (1)

Mentioning Analyses (5)

Tau propagation mechanisms and therapeutic interception points

Sleep disruption as cause and consequence of neurodegeneration

Senolytic therapy for age-related neurodegeneration

Autophagy-lysosome pathway convergence across neurodegenerative diseases

Mechanistic role of APOE in neurodegeneration

Experiments (0)

Related Papers (0)

Debates (7)

Hypothesis debate: SASP-Mediated Complement Cascade Amplification

Investigate prion-like spreading of tau pathology through connected brain region

Multiple NDDs converge on autophagy-lysosome dysfunction. Are there universal th

Senolytics targeting p16/p21+ senescent astrocytes and microglia may reduce SASP

Analysis question not specified

Sleep disruption as cause and consequence of neurodegeneration

Tau propagation mechanisms and therapeutic interception points

Related Research