concept

RAPAMYCIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAPAMYCIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1399Connections

1Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

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💡 Concept Info

Name	RAPAMYCIN
Key Genes/Proteins	ACTB, ACTIN, AIF1, AKT, ALPHA-SYNUCLEIN, ALS4
Related Diseases	aging, AGING, ALS, ALZHEIMER, Alzheimer Disease

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

clinical · 4511 words

→

Pathway Diagram

graph TD
    RAPAMYCIN["RAPAMYCIN"]
    RAPAMYCIN -->|"inhibits"| MTORC1["MTORC1"]
    RAPAMYCIN -->|"inhibits"| MTOR["MTOR"]
    RAPAMYCIN -->|"activates"| SQSTM1["SQSTM1"]
    RAPAMYCIN -->|"activates"| RAS["RAS"]
    RAPAMYCIN -->|"activates"| STEM_CELLS["STEM CELLS"]
    RAPAMYCIN -->|"activates"| TFEB["TFEB"]
    RAPAMYCIN -->|"activates"| ULK1["ULK1"]
    PEROXISOME["PEROXISOME"] -->|"activates"| RAPAMYCIN
    LYSOSOME["LYSOSOME"] -->|"activates"| RAPAMYCIN
    LAMP1["LAMP1"] -->|"activates"| RAPAMYCIN
    PI3K["PI3K"] -->|"activates"| RAPAMYCIN
    AKT["AKT"] -->|"activates"| RAPAMYCIN
    BECN1["BECN1"] -->|"activates"| RAPAMYCIN
    AMPK["AMPK"] -->|"activates"| RAPAMYCIN
    LC3["LC3"] -->|"activates"| RAPAMYCIN

Outgoing (664)

Target	Relation	Type	Str
MTOR	inhibits	gene	0.95
MTORC1	inhibits	protein	0.95
MTORC1	targets	protein	0.95
STEM CELLS	activates	cell_type	0.95
RAS	activates	gene	0.95
ULK1	activates	gene	0.95
SQSTM1	activates	gene	0.95
TFEB	activates	gene	0.95
MTOR	inhibits	gene	0.92
MAP1LC3	targets	gene	0.90
GAPDH	targets	gene	0.90
RAS	targets	gene	0.90
SQSTM1	downregulates	protein	0.90
ATG	targets	gene	0.90
Neurotoxic Astrocyte Effects	associated_with	phenotype	0.90
PI3K	targets	gene	0.90
Autophagy	activates	process	0.90
aging	prevents	process	0.90
SQSTM1	targets	gene	0.90
Neuronal Death	suppresses	phenotype	0.90
RNA	targets	gene	0.90
BECN1	targets	gene	0.90
MTOR	targets	gene	0.90
MAP1LC3B	targets	gene	0.90
AKT	targets	gene	0.90
ULK1	targets	gene	0.90
LAMP1	targets	gene	0.90
AMPK	targets	gene	0.90
MTORC1	targets	gene	0.90
mTOR	inhibits	protein	0.90
seizures	treats	phenotype	0.90
autophagy	upregulates	process	0.90
autophagy	activates	process	0.90
TFEB	activates	protein	0.90
TFEB	targets	gene	0.90
autophagy	activates	pathway	0.90
autophagy pathway	activates	pathway	0.90
GABARAP	targets	gene	0.90
GABA	targets	gene	0.90
LC3	targets	gene	0.90
MTOR	targets	protein	0.89
MTORC1	inhibits	protein	0.87
Apoptosis	inhibits	process	0.86
autophagy pathway	modulates	pathway	0.85
STING signaling	inhibits	process	0.85
Neurodegeneration	treats	disease	0.85
AUTOPHAGY	activates	process	0.85
Osteoarthritis	protects_against	disease	0.85
Pericyte Senescence	treats	phenotype	0.82
Sqstm1	downregulates	protein	0.80

Incoming (735)

Source	Relation	Type	Str
MTOR	targets	gene	0.95
LC3	activates	gene	0.95
PI3K	activates	gene	0.95
AUTOPHAGY	regulates	process	0.95
P62	activates	gene	0.95
MTOR	regulates	gene	0.95
BECN1	activates	gene	0.95
AMPK	activates	gene	0.95
AKT	activates	gene	0.95
LAMP1	activates	gene	0.95
MTOR	targets	gene	0.90
31112550	directly activates	paper	0.90
31112550	binds directly to	paper	0.90
APOPTOSIS	activates	process	0.80
GAPDH	activates	gene	0.80
MTOR	targets	gene	0.80
MOTOR NEURON	interacts_with	cell_type	0.65
ATAXIA	interacts_with	disease	0.65
P62	interacts_with	gene	0.65
PARKIN	activates	gene	0.65
RAGE	targets	gene	0.65
PSEN1	targets	gene	0.65
ATP	targets	gene	0.65
FRONTOTEMPORAL DEMENTIA	interacts_with	disease	0.65
P62	regulates	gene	0.65
ATG7	expressed_in	gene	0.65
NEURON	expressed_in	cell_type	0.65
GSK3B	interacts_with	gene	0.65
ISCHEMIA	targets	disease	0.65
FTD	interacts_with	disease	0.65
PSEN2	targets	gene	0.65
CREB	interacts_with	gene	0.65
HTT	interacts_with	gene	0.65
LAMP1	interacts_with	gene	0.65
LC3	targets	gene	0.65
NEURON	interacts_with	cell_type	0.65
PI3K	phosphorylates	gene	0.65
MLKL	targets	gene	0.65
ALS	interacts_with	disease	0.65
ISCHEMIA	regulates	disease	0.65
OPTN	phosphorylates	gene	0.65
LAMP1	regulates	gene	0.65
HUNTINGTON	interacts_with	disease	0.65
PARKIN	targets	gene	0.65
PARKINSON	targets	disease	0.65
ATP	regulates	gene	0.65
OPTN	targets	gene	0.65
LC3	regulates	gene	0.65
DEMENTIA	interacts_with	disease	0.65
NADH	regulates	gene	0.65

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Caloric Restriction Mimetic Combination Therapy (Metformin +	0.640	neurodegeneration	-

Mentioning Analyses (2)

Scientific analyses that reference this entity

Epigenetic clocks as biomarkers for Alzheimer disease and neurodegeneration

neurodegeneration | 2026-04-25 | 6 hypotheses Top: 0.387

Lysosomal dysfunction and cathepsin leakage in Alzheimer disease progression

neuroscience | 2026-04-04 | 7 hypotheses Top: 0.679

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Epigenetic clocks as biomarkers for Alzheimer disease and neurodegeneration

completed · Rounds: 5 · Score: 0.50 · 2026-04-25

Lysosomal membrane permeabilization releasing cathepsins triggers NLRP3 inflamma

closed · Rounds: 4 · Score: 0.76 · 2026-04-22

Related Research

Hypotheses and analyses mentioning RAPAMYCIN in their description or question text

No additional research found