protein

ATM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1366Connections

5Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ATM is a protein involved in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with AD, ALI, ALS. Connected to 589 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	ATM
Full Name	Ataxia-Telangiectasia Mutated
Chromosome	11q22.3
Protein Type	Serine/Threonine Kinase
Function	is a PIKK-family serine/threonine kinase that coordinates genomic stress responses, especially after DNA double-strand breaks.
Pathways	Akt, Apoptosis, Autophagy, Cell Cycle, Dna Damage Response
UniProt ID	[Q13315](https://www.uniprot.org/uniprotkb/Q13315)
Ensembl ID	ENSG00000149311
GeneCards	ATM
Human Protein Atlas	ATM
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	mtDNA, rapamycin
Interactions	ABCD3, ACETYL-COA, Actin, AGING, AKT, ALOX
KG Connections	1366 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ATM Gene

gene · 887 words

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Pathway Diagram

graph TD
    ATM["ATM"] -->|"expressed in"| synaptic_vesicles["synaptic vesicles"]
    ATM["ATM"] -->|"expressed in"| endosomes["endosomes"]
    ATM["ATM"] -->|"expressed in"| lysosomes["lysosomes"]
    ATM["ATM"] -->|"interacts"| ATR["ATR"]
    ATM["ATM"] -->|"interacts"| Dementia["Dementia"]
    ATM["ATM"] -->|"interacts"| Cardiovascular["Cardiovascular"]
    CAT["CAT"] -->|"interacts"| ATM["ATM"]
    OPTN["OPTN"] -->|"interacts"| ATM["ATM"]
    DNM1L["DNM1L"] -->|"interacts"| ATM["ATM"]
    CANX["CANX"] -->|"interacts"| ATM["ATM"]
    style ATM fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (953)

Target	Relation	Type	Str
Cancer	activates	disease	1.00
Tumor	associated_with	disease	0.90
Inflammation	activates	disease	0.85
Ataxia	activates	disease	0.85
Tumor	inhibits	disease	0.85
Senescence	activates	disease	0.85
Als	activates	disease	0.85
RFWD3	phosphorylates	gene	0.85
autophagy pathway	participates_in	pathway	0.80
neural stem cells	activates	cell_type	0.80
neural stem cells	regulates	cell_type	0.80
Ferroptosis	associated_with	process	0.80
DLBCL	biomarker_for	disease	0.80
mtDNA	modulates	compound	0.75
Cancer	associated_with	disease	0.75
Cancer	therapeutic_target	disease	0.75
Als	inhibits	disease	0.75
Cancer	inhibits	disease	0.75
Aging	activates	disease	0.75
Mitochondrial dysfunction	associated_with	phenotype	0.75
Als	associated_with	disease	0.75
ATR	interacts_with	protein	0.70
Apoptosis	therapeutic_target	pathway	0.70
Dna Repair	activates	pathway	0.70
Autophagy	activates	pathway	0.70
Apoptosis	activates	pathway	0.70
Mapk	activates	pathway	0.70
Dna Damage Response	associated_with	pathway	0.70
unfolded protein response	participates_in	pathway	0.70
Nf-Κb	activates	pathway	0.70
Autophagy-Lysosomal Pathway	regulates	biological_process	0.70
AUTOPHAGY	associated_with	phenotype	0.70
lysosomes	expressed_in	cell_type	0.70
TNF	inhibits	gene	0.70
CELL DEATH	regulates	phenotype	0.70
synaptic vesicles	expressed_in	cell_type	0.70
Ferroptosis	activates	pathway	0.70
TNF	stabilizes	gene	0.70
endosomes	expressed_in	cell_type	0.70
TDP-43	regulates	gene	0.70
MAP1LC3B	regulates	gene	0.70
DNA	disrupts	gene	0.70
neurons	activates	cell_type	0.70
epigenetic regulation	participates_in	pathway	0.70
senescence	participates_in	pathway	0.70
ULK1	activates	gene	0.70
STING1	regulates	gene	0.70
CREB	treats	gene	0.70
LC3	regulates	gene	0.70
Als	interacts_with	disease	0.65

Incoming (413)

Source	Relation	Type	Str
DNA	activates	gene	1.00
CANCER	activates	gene	1.00
INFLAMMATION	activates	gene	0.80
P53	activates	gene	0.80
TP53	inhibits	gene	0.80
CYTOKINES	activates	gene	0.70
GENES	inhibits	gene	0.70
CANCER	inhibits	gene	0.70
NF-ΚB	activates	gene	0.70
DNA	inhibits	gene	0.70
ATG	activates	gene	0.70
APOPTOSIS	therapeutic_target	gene	0.70
CANCER	therapeutic_target	gene	0.70
CANCER	associated_with	gene	0.70
FERROPTOSIS	causes	phenotype	0.70
ATG	regulates	gene	0.70
APOPTOSIS	activates	gene	0.70
GENES	activates	gene	0.70
AUTOPHAGY	transports	phenotype	0.65
FERROPTOSIS	interacts_with	phenotype	0.65
INFLAMMATION	therapeutic_target	gene	0.60
INFLAMMATION	associated_with	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
P53	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
MICROGLIA	associated_with	gene	0.60
VIRAL INFECTIONS	regulates	gene	0.60
AKT	expressed_in	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
AGING	therapeutic_target	gene	0.60
ERK	therapeutic_target	gene	0.60
INSULIN RESISTANCE	activates	gene	0.60
DIABETES MELLITUS	therapeutic_target	gene	0.60
APOPTOSIS	inhibits	gene	0.60
ALS	associated_with	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
NF-ΚB	associated_with	gene	0.60
APOPTOSIS	regulates	gene	0.60
ALOX	associated_with	gene	0.60
AGING	associated_with	gene	0.60
OXIDATIVE STRESS	expressed_in	gene	0.60
CANCER	regulates	gene	0.60
COMPLEMENT	interacts_with	gene	0.60
ROS	associated_with	gene	0.60
ATG	associated_with	gene	0.60
CYTOKINES	regulates	gene	0.60
ALPHA-SYNUCLEIN	activates	gene	0.60
SRXN1	biomarker_for	gene	0.60
FERROPTOSIS	associated_with	gene	0.60

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Multi-Biomarker Composite Index Surpassing Amyloid PET for T	0.933	neurodegeneration	What amyloid threshold level is required
Dynamic Microglial Phenotype Switching Biomarker Panel for N	0.577	neurodegeneration	What amyloid threshold level is required
Optogenetic restoration of hippocampal gamma oscillations vi	0.555	Alzheimer's disease	Circuit-level neural dynamics in neurode
Combined p-tau217 + p-tau231 Panel Increases Specificity for	0.546	neurodegeneration	-
CSF p-tau217 Threshold of <0.15 pg/mL Predicts Durable Clini	0.512	neurodegeneration	-

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ATM in their description or question text

No additional research found