gene 898 words KG: ERN1
Contents

ERN1 — Endoplasmic Reticulum To Nucleus Signaling 1

🧬 Gene Info
Gene SymbolERN1
Full NameEndoplasmic Reticulum To Nucleus Signaling 1
Chromosome6p24.3
Functionis an important component in the neurobiology of neurodegenerative diseases.
Amino Acids1210 aa
Exons54
PathwaysAkt, Apoptosis, Wnt
GeneCardsERN1
Human Protein AtlasERN1
Associated DiseasesAD, Aging, ALI, Als, Alzheimer
Known Drugs/Compoundsrapamycin
InteractionsABCD3, ACETYL-COA, Actin, AKT, AKT1, AKT1S1
KG Connections981 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (10)

Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Phase-Separated Organelle Targeting
Score: 0.73
Stress Granule Phase Separation Modulators
Score: 0.72
Purinergic Signaling Polarization Control
Score: 0.71
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
RNA Granule Nucleation Site Modulation
Score: 0.66
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62

Related Analyses (3)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (11)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
ABCD3 Gene
gene · KG edge: interacts_with
ACTB Gene
gene · KG edge: expressed_in
AKT1 Gene
gene · KG edge: interacts_with
AMBRA1 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

ERS activates ERN1
ERN1 interacts_with RB1
CAT interacts_with ERN1
OPTN interacts_with ERN1
DNM1L interacts_with ERN1
CANX interacts_with ERN1
LGALS3 interacts_with ERN1
CALCOCO2 interacts_with ERN1
G3BP1 interacts_with ERN1
PEX3 interacts_with ERN1

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