gene

LRRK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LRRK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2613Connections

3Hypotheses

5Analyses

50Outgoing

50Incoming

1Experiments

6Debates

Summary

A gene referenced in 1 knowledge graph relationship. Key connections: inhibits GCase_trafficking (mechanism).

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🧬 Gene Info

Gene Symbol	LRRK2
Full Name	Leucine Rich Repeat Kinase 2
Chromosome	12q12
Protein Type	Protein
Amino Acids	2527 aa
Pathways	MAPK
UniProt ID	Search UniProt
GeneCards	LRRK2
Human Protein Atlas	LRRK2
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Known Drugs/Compounds	BIIB094, Cigarette Smoking, Environmental Toxicants, levodopa, LPS, LRRK2 inhibitors
Interactions	6-OHDA, ACETYLCHOLINE, ACHE, Actin, AD, AKT
SciDEX Hypotheses	G2019S primarily raises baseline LRRK2 kinase acti
KG Connections	2611 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🧬 3D Structure Comparison — LRRK2 Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

6VP6 — X-ray / Cryo-EM

🔮 AI Predicted Structure

Q5S007 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    LRRK2["LRRK2"] -->|"causes"| PD["PD"]
    LRRK2["LRRK2"] -->|"associated"| Parkinson_s_disease["Parkinson's disease"]
    LRRK2["LRRK2"] -->|"regulates"| SNCA["SNCA"]
    LRRK2["LRRK2"] -->|"causes"| Parkinson_s_disease_1["Parkinson's disease"]
    LRRK2["LRRK2"] -.->|"inhibits"| Parkinson["Parkinson"]
    LRRK2["LRRK2"] -->|"implicated in"| Parkinson_2["Parkinson"]
    GABARAP["GABARAP"] -->|"binds"| LRRK2["LRRK2"]
    STING["STING"] -->|"activates"| LRRK2["LRRK2"]
    CASM_pathway["CASM pathway"] -->|"activates"| LRRK2["LRRK2"]
    GABARAP_3["GABARAP"] -->|"regulates"| LRRK2["LRRK2"]
    style LRRK2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1690)

Target	Relation	Type	Str
PARKINSON'S DISEASE	associated_with	disease	1.00
Parkinson	causes	disease	1.00
PARKINSON	associated_with	gene	1.00
Parkinson	associated_with	disease	1.00
PARKIN	associated_with	gene	0.98
Mitochondrial Protection	inhibits	process	0.95
Parkinson'S Disease	causes	disease	0.95
Als	associated_with	disease	0.95
Parkinson Disease	risk_factor_for	disease	0.95
Macroautophagy	regulates	process	0.95
Parkinson's Disease	causes	disease	0.95
RAB	interacts_with	protein	0.95
Familial Parkinson'S Disease	associated_with	disease	0.95
Parkinson Disease	causes	disease	0.95
Parkinson'S Disease	therapeutic_target	disease	0.95
Parkinson's Disease	associated_with	disease	0.95
Parkinson	therapeutic_target	disease	0.95
Autophagy Process	regulates	process	0.95
Rab GTPases	phosphorylates	protein	0.92
MEK	activates	protein	0.90
oxidative stress response	participates_in	pathway	0.90
Α-SYNUCLEIN	associated_with	protein	0.90
Autophagy-Lysosomal Pathway	regulates	pathway	0.90
Parkinson's disease	activates	disease	0.90
RAB8A	phosphorylates	protein	0.90
RAB GTPASES	phosphorylates	protein	0.90
NRF2	regulates	protein	0.90
α-Synuclein Oligomer Accumulation	associated_with	process	0.90
Kinase Activation	involved_in	mechanism	0.90
Autophagy Pathway	involved_in	pathway	0.90
RAB PROTEINS	targets	protein	0.90
Parkinson's disease	regulates	disease	0.90
G2019S LRRK2	associated_with	protein	0.90
PARKINSON DISEASE	associated_with	disease	0.90
Paneth Cell Dysfunction	causes	phenotype	0.90
MLi-2	targets	drug	0.90
Chaperone-Mediated Autophagy	modulates	pathway	0.90
NFE2L2	inhibits	gene	0.90
Serine 1292 Autophosphorylation	phosphorylates	biomarker	0.90
PINK1/parkin-mediated mitophagy	inhibits	pathway	0.90
Sporadic Parkinson'S Disease	implicated_in	disease	0.90
Type I Interferon Signaling	modulates	pathway	0.90
autophosphorylation	upregulates	process	0.90
Lysosomal stress	associated_with	process	0.90
Crohn's Disease	risk_factor_for	disease	0.90
G2019S mutation	associated_with	compound	0.90
Monocytes	expressed_in	cell_type	0.90
PARKINSON	therapeutic_target	gene	0.90
Endolysosomal Dysfunction	causes	process	0.88
Dysfunctional Alternative Polyadenylation	associated_with	process	0.88

Incoming (923)

Source	Relation	Type	Str
entities-dna-methylation	associated_with	wiki	0.00
entities-snx5	associated_with	wiki	0.00
entities-histone-modifications	interacts_with	wiki	0.00
RAB29	reduces endogenous	protein	1.00
RAB29	operates in a common pathway with	protein	1.00
RAB29	recruits	protein	1.00
PARKINSON'S DISEASE	associated_with	gene	1.00
GABARAP	binds	gene	0.95
LRRK2 kinase inhibitors	inhibits	drug	0.95
BIIB094	targets	drug	0.95
G2019S	associated_with	biomarker	0.95
LRRK2 Inhibitors	inhibits	drug	0.95
INTERFERON GAMMA	upregulates	protein	0.90
Alternative Polyadenylation	modulates	process	0.90
RAB	activates	protein	0.90
PF-06447475	inhibits	drug	0.90
MLi-2	inhibits	drug	0.90
STING	activates	protein	0.90
CASM pathway	activates	pathway	0.90
RAB29	regulates	protein	0.90
PARKINSON'S DISEASE	therapeutic_target	gene	0.90
PPM1H	inhibits	protein	0.88
ALZHEIMER'S DISEASE	associated_with	disease	0.88
PIKFYVE	regulates	protein	0.85
CRISPR-Cas9	targets	process	0.85
Oxidative Stress	activates	process	0.85
Endolysosomal Dysfunction	activates	process	0.85
VPS35	associated_with	protein	0.85
Chaperone Network	regulates	pathway	0.80
Environmental Toxicants	activates	compound	0.80
MIRO1	interacts_with	protein	0.80
GCASE	interacts_with	protein	0.80
IFN	interacts_with	gene	0.80
EEF2	phosphorylates	gene	0.80
lysosome damage	activates	phenotype	0.80
GABARAP	regulates	protein	0.80
NEURODEGENERATION	associated_with	gene	0.80
PINK1	associated_with	gene	0.80
Cigarette Smoking	activates	compound	0.75
DOPAMINERGIC	associated_with	cell_type	0.70
ATP13A2	expressed_in	gene	0.70
ACHE	inhibits	gene	0.70
FRONTOTEMPORAL DEMENTIA	interacts_with	disease	0.70
BDNF	interacts_with	gene	0.70
DYRK1A	activates	gene	0.70
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	disease	0.70
FTD	interacts_with	disease	0.70
APP	interacts_with	gene	0.70
AMPK	targets	gene	0.70
LAMP1	interacts_with	gene	0.70

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
G2019S primarily raises baseline LRRK2 kinase activity rathe	0.790	neurodegeneration	Do pathogenic LRRK2 mutations amplify vo
A downstream LRRK2-Rab10-JIP4 lysosomal stress loop promotes	0.680	neurodegeneration	Do pathogenic LRRK2 mutations amplify vo
LRRK2 Volume Sensor Hijacking Drives Metabolic Dysregulation	0.666	neurodegeneration	Does LRRK2's role as a lysosomal volume

Mentioning Analyses (5)

Scientific analyses that reference this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Never Develo	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,730,000

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (6)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning LRRK2 in their description or question text

No additional research found

LRRK2

Understanding Entity Pages

Summary

Wiki Pages (21)

LRRK2 — Leucine Rich Repeat Kinase 2

LRRK2 Kinase Activation and Endolysosomal Dysfunction in Parkinson's Disease

LRRK2 Pathway in Parkinson's Disease

LRRK2 G2019S

LRRK2 Transgenic Mouse Model for Parkinson's Disease

LRRK2 Consortium

Pathway Diagram

Outgoing (1690)

Incoming (923)

Targeting Hypotheses (3)

Mentioning Analyses (5)

Does LRRK2's role as a lysosomal volume sensor explain the pathogenic mechanism

Neuroinflammation and microglial priming in early Alzheimer's Disease

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas

Digital biomarkers and AI-driven early detection of neurodegeneration

Experiments (1)

Related Papers (0)

Debates (6)

While the study establishes LRRK2 as a lysosomal swelling sensor and notes that

Investigate mechanistic links between early microglial priming states, neuroinfl

Investigate mechanistic links between early microglial priming states, neuroinfl

Can speech, gait, retinal imaging, sleep, and smartphone data detect neurodegene

What cell types are most vulnerable in Alzheimer's Disease based on SEA-AD trans

Cell-type specific expression patterns of neurodegeneration genes in SEA-AD

Related Research

LRRK2

Understanding Entity Pages

Summary

Wiki Pages (21)

LRRK2 — Leucine Rich Repeat Kinase 2

LRRK2 Kinase Activation and Endolysosomal Dysfunction in Parkinson's Disease

LRRK2 Pathway in Parkinson's Disease

LRRK2 G2019S

LRRK2 Transgenic Mouse Model for Parkinson's Disease

LRRK2 Consortium

Parabacteroides goldsteinii Mitigation of Parkinsonism in LRRK2 Mice

LRRK2-GBA Combination Therapy for Parkinson's Disease

LRRK2 (Leucine-Rich Repeat Kinase 2) — Comprehensive Gene Review

LRRK2 Kinase-Targeting Therapies

LRRK2 Kinase Pathway in Parkinson's Disease

LRRK2→Kinase→Autophagy→PD Causal Chain

LRRK2 Signaling Pathway in Parkinson's Disease

LRRK2 Therapeutics: Investment Landscape Analysis

alpha-synuclein-LRRK2 Crosstalk

LRRK2 Pathway in PD

LRRK2 Signaling Pathway in Parkinson's Disease

AAV-LRRK2 IND-Enabling Study Design

LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Never Develop PD

LRRK2 Inhibitor Therapy

LRRK2 Kinase Inhibition in Parkinson's Disease - Therapeutic Mechanism

Pathway Diagram

Outgoing (1690)

Incoming (923)

Targeting Hypotheses (3)

Mentioning Analyses (5)

Does LRRK2's role as a lysosomal volume sensor explain the pathogenic mechanism

Neuroinflammation and microglial priming in early Alzheimer's Disease

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas

Digital biomarkers and AI-driven early detection of neurodegeneration

Experiments (1)

Related Papers (0)

Debates (6)

While the study establishes LRRK2 as a lysosomal swelling sensor and notes that

Investigate mechanistic links between early microglial priming states, neuroinfl

Investigate mechanistic links between early microglial priming states, neuroinfl

Can speech, gait, retinal imaging, sleep, and smartphone data detect neurodegene

What cell types are most vulnerable in Alzheimer's Disease based on SEA-AD trans

Cell-type specific expression patterns of neurodegeneration genes in SEA-AD

Related Research