gene

TAX1BP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TAX1BP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

748Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

TAX1BP1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, regulates, activates. Associated with AD, ALI, ALS. Connected to 318 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TAX1BP1
Chromosome	7p15.2
Protein Type	Receptor
Function	Mitophagy: Recognizes ubiquitinated damaged mitochondria through its UBZ domain
Primary Expression	various tissues with particularly high expression in immune cells and the brain
Molecular Weight	90 kDa
Amino Acids	789 aa
Exons	14
Pathways	NF-κB
Ensembl ID	ENSG00000133107
GeneCards	TAX1BP1
Human Protein Atlas	TAX1BP1
LIR motif (LC3-interacting region)	For autophagy receptor function
Coiled-coil domains	Mediate protein-protein interactions
Multiple UBDs	Ubiquitin-binding domains throughout
Associated Diseases	AD, ALI, Als, Alzheimer, AMI
Interactions	ABCD3, ACTB, Actin, ALS, ALZHEIMER, ALZHEIMER DISEASE
KG Connections	748 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TAX1BP1 Gene

gene · 1362 words

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Pathway Diagram

graph TD
    TAX1BP1["TAX1BP1"] -->|"Interacts With"| FIP200["FIP200"]
    TAX1BP1["TAX1BP1"] -->|"Degrades"| p62["p62"]
    TAX1BP1["TAX1BP1"] -->|"Regulates"| neural_stem_cells["neural stem cells"]
    TAX1BP1["TAX1BP1"] -->|"Regulates"| autophagy["autophagy"]
    TAX1BP1["TAX1BP1"] -->|"Interacts With"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    TAX1BP1["TAX1BP1"] -->|"Interacts With"| Dementia["Dementia"]
    TAX1BP1["TAX1BP1"] -->|"Interacts With"| Als["Als"]
    TAX1BP1["TAX1BP1"] -->|"Interacts With"| Cardiovascular["Cardiovascular"]
    ACTB["ACTB"] -->|"Interacts With"| TAX1BP1["TAX1BP1"]
    OPTN["OPTN"] -->|"Interacts With"| TAX1BP1["TAX1BP1"]
    ULK1["ULK1"] -->|"Interacts With"| TAX1BP1["TAX1BP1"]
    SMCR8["SMCR8"] -->|"Interacts With"| TAX1BP1["TAX1BP1"]
    CALCOCO2["CALCOCO2"] -->|"Interacts With"| TAX1BP1["TAX1BP1"]
    style TAX1BP1 fill:#8d4900,color:#e0e0e0
    style FIP200 fill:#8d4900,color:#e0e0e0
    style p62 fill:#0d47a1,color:#e0e0e0
    style neural_stem_cells fill:#795548,color:#e0e0e0
    style autophagy fill:#9C27B0,color:#e0e0e0
    style Amyotrophic_Lateral_Sclerosis fill:#b71c1c,color:#e0e0e0
    style Dementia fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style ACTB fill:#8d4900,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style ULK1 fill:#8d4900,color:#e0e0e0
    style SMCR8 fill:#8d4900,color:#e0e0e0
    style CALCOCO2 fill:#8d4900,color:#e0e0e0

Outgoing (322)

Target	Relation	Type	Str
p62	inhibits	protein	0.90
FIP200	interacts_with	gene	0.90
macroautophagy	regulates	process	0.90
neural stem cells	regulates	cell_type	0.90
GPX4	modulates	protein	0.90
FIP200	associated_with	protein	0.85
xenophagy	promotes	process	0.85
PARP5A	interacts_with	protein	0.85
innate immune response	modulates	process	0.80
autophagy pathway	participates_in	pathway	0.80
ubiquitin-proteasome	participates_in	pathway	0.80
Autophagy	activates	pathway	0.80
Autophagy	interacts_with	pathway	0.80
Als	interacts_with	disease	0.75
Als	regulates	disease	0.75
Innate Immunity	regulates	pathway	0.70
Nf-Κb	regulates	pathway	0.70
autophagy	regulates	pathway	0.70
Mitophagy	interacts_with	pathway	0.70
TBK1	regulates	gene	0.70
TBK1	interacts_with	gene	0.70
frontotemporal dementia	activates	disease	0.70
GABARAP	interacts_with	gene	0.70
oxidative stress response	participates_in	pathway	0.70
ALS	activates	disease	0.70
P62	interacts_with	gene	0.70
Autophagy	inhibits	pathway	0.70
ALS	regulates	disease	0.70
AUTOPHAGY	inhibits	gene	0.70
AUTOPHAGY	interacts_with	gene	0.70
necroptosis	participates_in	pathway	0.70
frontotemporal dementia	regulates	disease	0.70
Necroptosis	interacts_with	disease	0.65
Aging	activates	disease	0.65
Infection	regulates	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Ftd	interacts_with	disease	0.65
Inflammation	inhibits	disease	0.65
Dementia	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Cancer	activates	disease	0.65
Breast Cancer	activates	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Ms	regulates	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Neurodegeneration	activates	disease	0.65

Incoming (426)

Source	Relation	Type	Str
AUTOPHAGY	activates	gene	0.80
NEURODEGENERATIVE DISEASES	regulates	gene	0.70
LC3B	activates	gene	0.70
CGAS-STING	regulates	gene	0.70
UBIQUITIN	activates	gene	0.70
NF-ΚB	regulates	gene	0.70
ALS	regulates	gene	0.70
BECN1	regulates	gene	0.70
P62	associated_with	gene	0.70
OPTN	activates	gene	0.70
PINK1	interacts_with	gene	0.70
CGAS	regulates	gene	0.70
SQSTM1	regulates	gene	0.70
G3BP1	regulates	gene	0.70
P62	activates	gene	0.70
FIP200	interacts_with	gene	0.70
LC3	regulates	gene	0.70
NDP52	activates	gene	0.70
STING	activates	gene	0.70
TBK1	regulates	gene	0.70
OPTN	regulates	gene	0.70
NBR1	activates	gene	0.70
CALCOCO2	regulates	gene	0.70
NDP52	regulates	gene	0.70
AUTOPHAGY	interacts_with	gene	0.70
PARKIN	interacts_with	gene	0.70
NDP52	interacts_with	gene	0.70
LC3	interacts_with	gene	0.70
MITOPHAGY	interacts_with	gene	0.70
RAS	activates	gene	0.60
ACTB	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
SMCR8	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
C9ORF72	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
RNA	expressed_in	gene	0.60
CAT	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
CTSD	activates	entity	0.60
MAPK8	interacts_with	gene	0.60
BCL2L11	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
NLRP3	interacts_with	gene	0.60
FUNDC1	interacts_with	gene	0.60
EMD	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TAX1BP1 in their description or question text

No additional research found