gene

STAT3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STAT3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3839Connections

5Hypotheses

7Analyses

50Outgoing

50Incoming

0Experiments

8Debates

Summary

Signal Transducer and Activator of Transcription 3 - key transcription factor in neuroinflammation and neuronal survival

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🧬 Gene Info

Gene Symbol	STAT3
Full Name	Signal Transducer and Activator of Transcription 3
Chromosome	17q21.2
Protein Type	Transcription Factor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	92 kDa
Amino Acids	770 aa
Pathways	Akt, Amyloid, Angiogenesis, Apoptosis, Autophagy
UniProt ID	[P40763](https://www.uniprot.org/uniprot/P40763)
Ensembl ID	ENSG00000168610
GeneCards	STAT3
Human Protein Atlas	STAT3
Associated Diseases	acute lung injury, Aging, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	Acetyl-CoA, BARICITINIB, Benzo[a]pyrene, curcumin, Curcumin, dimethyl fumarate
Interactions	ABCG2, acetyl-CoA, ACETYL-COA, ACHE, ACSL4, Actin
KG Connections	3788 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    STAT3["STAT3"] -->|"regulates"| MMP9["MMP9"]
    STAT3["STAT3"] -->|"regulates"| GFAP["GFAP"]
    STAT3["STAT3"] -->|"regulates"| MYC["MYC"]
    STAT3["STAT3"] -->|"regulates"| BCL2["BCL2"]
    STAT3["STAT3"] -->|"interacts"| Cancer["Cancer"]
    STAT3["STAT3"] -->|"interacts"| Als["Als"]
    JAK["JAK"] -->|"activates"| STAT3["STAT3"]
    GP130["GP130"] -->|"activates"| STAT3["STAT3"]
    TSPAN8["TSPAN8"] -->|"interacts"| STAT3["STAT3"]
    TRF33["TRF33"] -.->|"inhibits"| STAT3["STAT3"]
    style STAT3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (2150)

Target	Relation	Type	Str
CYTOKINES	activates	gene	1.00
INFLAMMATION	therapeutic_target	gene	1.00
Autoimmune	activates	disease	1.00
INFLAMMATION	activates	gene	1.00
IL-6	inhibits	gene	1.00
CANCER	therapeutic_target	gene	1.00
IL-6	activates	entity	1.00
CANCER	inhibits	gene	1.00
Inflammation	therapeutic_target	disease	1.00
Angiogenesis	activates	pathway	1.00
Inflammation	associated_with	disease	1.00
Cancer	regulates	disease	1.00
INFLAMMATION	inhibits	gene	1.00
Inflammation	inhibits	disease	1.00
Tumor	therapeutic_target	disease	1.00
CANCER	regulates	disease	1.00
Tumor	regulates	disease	1.00
NF-ΚB	associated_with	gene	1.00
Neurodegeneration	activates	disease	1.00
Alzheimer	activates	disease	1.00
Als	inhibits	disease	1.00
Nf-Κb	regulates	pathway	1.00
Jak-Stat	activates	pathway	1.00
Cancer	inhibits	disease	1.00
Apoptosis	activates	pathway	1.00
CANCER	activates	disease	1.00
TNF-Α	inhibits	gene	1.00
NEUROINFLAMMATION	activates	gene	1.00
Carcinoma	activates	disease	1.00
Tumor	activates	disease	1.00
Apoptosis	inhibits	pathway	1.00
Inflammation	activates	disease	1.00
Tumor	inhibits	disease	1.00
Aging	activates	disease	1.00
Autophagy	activates	pathway	1.00
Inflammation	regulates	disease	1.00
GENES	activates	gene	1.00
Cancer	associated_with	disease	1.00
Cancer	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
Nf-Κb	activates	pathway	1.00
Neuroinflammation	activates	disease	1.00
Als	activates	disease	1.00
PI3K	therapeutic_target	gene	1.00
Als	regulates	disease	1.00
Immune Response	activates	pathway	1.00
AKT	therapeutic_target	gene	1.00
Cancer	activates	disease	1.00
JAK2	activates	gene	1.00
INFLAMMATION	associated_with	gene	1.00

Incoming (1689)

Source	Relation	Type	Str
IL-6	associated_with	gene	1.00
APOPTOSIS	therapeutic_target	gene	1.00
ds-db4a006ea647	data_in	dataset	1.00
APOPTOSIS	activates	gene	1.00
TNF	activates	gene	1.00
ALZHEIMER'S DISEASE	associated_with	disease	1.00
APOPTOSIS	regulates	gene	1.00
ROS	activates	gene	1.00
TNF	inhibits	gene	1.00
CASP3	associated_with	gene	0.98
NEUROINFLAMMATION	associated_with	concept	0.98
CASP3	activates	gene	0.95
LEPTIN	activates	protein	0.95
FYN	activates	gene	0.95
MN	downregulates	compound	0.95
PHF2	regulates	enzyme	0.95
IPA	inhibits	compound	0.95
IL-6R	activates	protein	0.95
ILA	inhibits	drug	0.95
CHI3L1	binds_to	protein	0.95
Polyphyllin B	binds_to	drug	0.95
isoquercitrin	binds_to	drug	0.95
LRWE	downregulates	compound	0.95
leptin signaling	activates	pathway	0.92
Cyclosporine A	upregulates	drug	0.92
JAK	activates	protein	0.90
JAK2	activates	protein	0.90
PPP1CB	modifies	protein	0.90
JAK1	activates	protein	0.90
JAK2	phosphorylates	protein	0.90
IL6	activates	protein	0.90
BRSK2	activates	protein	0.90
Curcumin	suppresses	drug	0.90
TRIM32	inhibits	protein	0.90
SBP	downregulates	drug	0.90
NF-KB	associated_with	protein	0.90
Curcumin	inhibits	drug	0.90
IL6	interacts_with	protein	0.90
FAK	activates	protein	0.90
PKM2	phosphorylates	protein	0.90
NF-KB	interacts_with	pathway	0.90
JAK	phosphorylates	protein	0.90
ACETYL-COA	activates	gene	0.90
JAK	associated_with	gene	0.90
AKT1	therapeutic_target	gene	0.90
TNF	therapeutic_target	gene	0.90
ERK	activates	gene	0.90
PD-L1	binds_to	protein	0.89
S1PR1	phosphorylates	protein	0.88
SD36	inhibits	drug	0.88

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
PDGF-BB/PDGFRβ/STAT3 Paracrine Signaling Axis Mediates Aβ-In	0.618	neurodegeneration	How do perivascular cells specifically r
Astrocytic SPP1 Modulation Through STAT3-Dependent Transcrip	0.551	neuroinflammation	What molecular mechanisms mediate SPP1-i
Systemic IL-6–STAT3–Hepatic C3 Axis and BBB-Mediated Complem	0.540	neuroinflammation	How does sevoflurane-induced NF-κB activ
Astrocytic SPP1 Modulation via STAT3-Dependent Transcription	0.459	neuroinflammation	What molecular mechanisms mediate SPP1-i
RAGE/STAT3/IL-6 Autocrine Loop Mediates Aβ-Induced SPP1 Upre	0.442	neurodegeneration	How do perivascular cells specifically r