Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PARKINSON: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
PARKINSON is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with ALS, ALZHEIMER'S, ALZHEIMER'S DISEASE. Connected to 2646 entities in the SciDEX knowledge graph.
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| Gene Symbol | PARKINSON |
| STN DBS | Subthalamic nucleus stimulation |
| GPi DBS | Internal segment of globus pallidus stimulation |
| Associated Diseases | Addiction, aging, Als, Alzheimer |
| Known Drugs/Compounds | LEVODOPA, RAPAMYCIN, RESVERATROL |
| Interactions | 6-OHDA, AADC, ABCB1, ABCD3, ACETYL-COA, ACHE |
| KG Connections | 6128 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
subgraph Pathology["Pathology"]
PARKINSON["PARKINSON"] -->|"associated with"| ALS["ALS"]
PARKINSON["PARKINSON"] -->|"associated with"| Parkinson["Parkinson"]
PARKINSON["PARKINSON"] -->|"associated with"| CANCER["CANCER"]
PARKINSON["PARKINSON"] -->|"associated with"| AGING["AGING"]
PARKINSON["PARKINSON"] -->|"associated with"| Aging["Aging"]
PARKINSON["PARKINSON"] -->|"associated with"| Alzheimer["Alzheimer"]
PARKINSON["PARKINSON"] -->|"associated with"| Cancer["Cancer"]
PARKINSON["PARKINSON"] -->|"associated with"| NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"associated with"| PARKINSON["PARKINSON"]
OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"associated with"| PARKINSON["PARKINSON"]
APOPTOSIS["APOPTOSIS"] -->|"associated with"| PARKINSON["PARKINSON"]
end
subgraph Interactions["Interactions"]
PARKINSON["PARKINSON"] -->|"interacts with"| Parkinson_1["Parkinson"]
end
subgraph Signaling["Signaling"]
PARKINSON_S_DISEASE_2["PARKINSON'S DISEASE"] -.->|"inhibits"| PARKINSON["PARKINSON"]
PARKINSON_S_DISEASE_3["PARKINSON'S DISEASE"] -->|"regulates"| PARKINSON["PARKINSON"]
PARKINSON_S_DISEASE_4["PARKINSON'S DISEASE"] -->|"activates"| PARKINSON["PARKINSON"]
end
style PARKINSON fill:#4a1a6b,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
style ALS fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Parkinson fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Parkinson_1 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style CANCER fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style AGING fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Aging fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Alzheimer fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Cancer fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style NEURODEGENERATIVE_DISEASES fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style PARKINSON_S_DISEASE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style OXIDATIVE_STRESS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style PARKINSON_S_DISEASE_2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style PARKINSON_S_DISEASE_3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style PARKINSON_S_DISEASE_4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style APOPTOSIS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Autophagy | activates | pathway | 1.00 |
| NEURODEGENERATIVE DISORDERS | causes | gene | 1.00 |
| Neurodegeneration | inhibits | disease | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| HUNTINGTON'S DISEASE | associated_with | gene | 1.00 |
| Oxidative Stress | associated_with | pathway | 1.00 |
| NEURODEGENERATIVE DISEASES | regulates | gene | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| NEURODEGENERATIVE DISORDERS | associated_with | gene | 1.00 |
| Depression | associated_with | disease | 1.00 |
| GENES | activates | gene | 1.00 |
| Stroke | activates | disease | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| Neuroinflammation | associated_with | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| NEURODEGENERATIVE DISORDERS | regulates | gene | 1.00 |
| Neuroinflammation | activates | disease | 1.00 |
| Parkinson | inhibits | disease | 1.00 |
| Aging | associated_with | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Neurodegeneration | protects_against | disease | 1.00 |
| NEURODEGENERATIVE DISORDERS | activates | gene | 1.00 |
| Oxidative Stress | associated_with | pathway | 1.00 |
| NEUROINFLAMMATION | associated_with | gene | 1.00 |
| Als | associated_with | disease | 1.00 |
| NEURODEGENERATIVE DISEASES | associated_with | gene | 1.00 |
| Mitophagy | activates | pathway | 1.00 |
| Neurodegeneration | interacts_with | disease | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| NEUROINFLAMMATION | activates | gene | 1.00 |
| Immune Response | activates | pathway | 1.00 |
| Huntington | associated_with | disease | 1.00 |
| Mitophagy | associated_with | pathway | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| Parkinson | associated_with | disease | 1.00 |
| ALS | associated_with | disease | 1.00 |
| Blood-Brain Barrier | therapeutic_target | pathway | 1.00 |
| CANCER | associated_with | gene | 1.00 |
| Multiple Sclerosis | associated_with | disease | 1.00 |
| AUTOPHAGY | associated_with | gene | 1.00 |
| Multiple Sclerosis | associated_with | disease | 1.00 |
| AGING | associated_with | gene | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| Autophagy | associated_with | pathway | 1.00 |
| Amyotrophic Lateral Sclerosis | associated_with | disease | 1.00 |
| AMYOTROPHIC LATERAL SCLEROSIS | associated_with | gene | 1.00 |
| Mitophagy | associated_with | pathway | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NEURODEGENERATION | contributes_to | gene | 1.00 |
| NEURODEGENERATIVE DISORDERS | contributes_to | gene | 1.00 |
| PARKINSON | interacts_with | gene | 1.00 |
| HUNTINGTON | associated_with | gene | 1.00 |
| PARKINSON | inhibits | gene | 1.00 |
| PARKINSON'S DISEASE | inhibits | gene | 1.00 |
| PARKINSON'S DISEASE | associated_with | gene | 1.00 |
| PARKINSON | associated_with | gene | 1.00 |
| ALZHEIMER | associated_with | gene | 1.00 |
| PARKINSON'S DISEASE | expressed_in | gene | 1.00 |
| OXIDATIVE STRESS | associated_with | gene | 1.00 |
| MITOCHONDRIA | regulates | gene | 1.00 |
| NEURODEGENERATION | causes | gene | 1.00 |
| HUNTINGTON | regulates | gene | 1.00 |
| NEURODEGENERATIVE DISORDERS | activates | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | contributes_to | gene | 1.00 |
| APOPTOSIS | associated_with | gene | 1.00 |
| ALZHEIMER'S DISEASE | therapeutic_target | gene | 1.00 |
| EXERCISE | activates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | regulates | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| NEURODEGENERATION | biomarker_for | gene | 1.00 |
| MICROGLIA | associated_with | gene | 1.00 |
| PINK1 | associated_with | gene | 1.00 |
| NEURODEGENERATION | interacts_with | gene | 1.00 |
| AGING | activates | gene | 1.00 |
| NEURON | associated_with | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | expressed_in | gene | 1.00 |
| ALZHEIMER | regulates | gene | 1.00 |
| AMYOTROPHIC LATERAL SCLEROSIS | activates | gene | 1.00 |
| SIRT1 | activates | gene | 1.00 |
| ALPHA-SYNUCLEIN | activates | gene | 1.00 |
| AKT | therapeutic_target | gene | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| LRRK2 | associated_with | gene | 1.00 |
| MITOCHONDRIAL DYSFUNCTION | activates | gene | 1.00 |
| INFLAMMATION | regulates | gene | 1.00 |
| FERROPTOSIS | associated_with | gene | 1.00 |
| PARKIN | associated_with | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | activates | gene | 1.00 |
| NEUROINFLAMMATION | associated_with | gene | 1.00 |
| PINK1 | activates | gene | 1.00 |
| NEURODEGENERATION | inhibits | gene | 1.00 |
| PTEN | activates | gene | 1.00 |
| PARKINSON'S DISEASE | interacts_with | gene | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| PARKIN | regulates | gene | 1.00 |
| PINK1 | regulates | gene | 1.00 |
| PARKINSON'S DISEASE | regulates | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity