protein

DNA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5282Connections

18Hypotheses

14Analyses

50Outgoing

50Incoming

11Experiments

18Debates

Summary

DNA is a protein involved in neurodegeneration research. Key relationships include: activates, associated with, interacts with. Associated with AD, ALI, ALS. Connected to 2929 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	DNA
Function	is an epigenetic modification that regulates gene expression without changing the DNA sequence.
Pathways	AMPK signaling, Adaptive Immunity, Akt, Amyloid, Angiogenesis
GeneCards	DNA
Human Protein Atlas	DNA
Associated Diseases	AD, Addiction, aging, ALI, Als
Known Drugs/Compounds	ketamine, metformin, rapamycin, resveratrol, valproic acid
Interactions	A2M, ABCB1, ABCD3, ACETYL-COA, ACTB, Actin
KG Connections	5276 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    subgraph Signaling["Signaling"]
        DNA["DNA"] -->|"activates"| CGAS["CGAS"]
        DNA["DNA"] -.->|"inhibits"| Cancer_2["Cancer"]
        DNA["DNA"] -.->|"inhibits"| Tumor_3["Tumor"]
        STING["STING"] -->|"activates"| DNA["DNA"]
        CGAS_4["CGAS"] -->|"activates"| DNA["DNA"]
        MTDNA["MTDNA"] -->|"activates"| DNA["DNA"]
        MITOCHONDRIAL_DNA_5["MITOCHONDRIAL DNA"] -->|"activates"| DNA["DNA"]
    end
    subgraph Pathology["Pathology"]
        DNA["DNA"] -->|"associated with"| GENES["GENES"]
        DNA["DNA"] -->|"associated with"| Alzheimer["Alzheimer"]
        DNA["DNA"] -->|"associated with"| Als_1["Als"]
        ROS["ROS"] -->|"causes"| DNA["DNA"]
        MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"] -->|"associated with"| DNA["DNA"]
    end
    subgraph Therapeutic["Therapeutic"]
        DNA["DNA"] -->|"therapeutic target"| Cancer["Cancer"]
        DNA["DNA"] -->|"expressed in"| Als["Als"]
    end
    subgraph Interactions["Interactions"]
        DNA["DNA"] -->|"interacts with"| Tumor["Tumor"]
    end
    style DNA fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
    style CGAS fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style GENES fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Als fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Alzheimer fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Als_1 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Tumor fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Cancer_2 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Tumor_3 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ROS fill:#5d4400,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style MITOCHONDRIAL_DNA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style STING fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style CGAS_4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style MTDNA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style MITOCHONDRIAL_DNA_5 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0

Outgoing (3291)

Target	Relation	Type	Str
Alzheimer	therapeutic_target	disease	1.00
Inflammation	activates	disease	1.00
Inflammation	regulates	disease	1.00
Aging	inhibits	disease	1.00
Amyotrophic Lateral Sclerosis	interacts_with	disease	1.00
Aging	regulates	disease	1.00
Tumor	interacts_with	disease	1.00
Als	regulates	disease	1.00
Cancer	inhibits	disease	1.00
Epigenetic	regulates	pathway	1.00
Neurodegeneration	activates	disease	1.00
Als	therapeutic_target	disease	1.00
Als	interacts_with	disease	1.00
Aging	activates	disease	1.00
Carcinoma	associated_with	disease	1.00
Neurodegeneration	associated_with	disease	1.00
Cancer	therapeutic_target	disease	1.00
Als	expressed_in	disease	1.00
Immune Response	associated_with	pathway	1.00
Alzheimer	associated_with	disease	1.00
Cancer	regulates	disease	1.00
Cancer	interacts_with	disease	1.00
Tumor	therapeutic_target	disease	1.00
Inflammation	associated_with	disease	1.00
Tumor	regulates	disease	1.00
Cardiovascular	therapeutic_target	disease	1.00
Epigenetic	associated_with	pathway	1.00
Epigenetic	therapeutic_target	pathway	1.00
Aging	associated_with	disease	1.00
Als	activates	disease	1.00
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	1.00
CANCER	associated_with	gene	1.00
Infection	causes	disease	1.00
Dna Methylation	associated_with	pathway	1.00
Oxidative Stress	regulates	pathway	1.00
CGAS	activates	protein	1.00
Lung Cancer	therapeutic_target	disease	1.00
Immune Response	regulates	pathway	1.00
Oxidative Stress	causes	pathway	1.00
Oxidative Stress	associated_with	pathway	1.00
Tumor	associated_with	disease	1.00
Cancer	associated_with	disease	1.00
Als	associated_with	disease	1.00
Autophagy	associated_with	pathway	1.00
Innate Immunity	activates	pathway	1.00
Tumor	inhibits	disease	1.00
Dna Repair	associated_with	pathway	1.00
Tumor	treats	disease	1.00
GENES	associated_with	gene	1.00
Immune Response	activates	pathway	1.00

Incoming (1991)

Source	Relation	Type	Str
CANCER	regulates	gene	1.00
AUTOPHAGY	associated_with	gene	1.00
MITOCHONDRIAL DYSFUNCTION	activates	gene	1.00
UBIQUITIN	regulates	gene	1.00
ROS	regulates	gene	1.00
ROS	activates	gene	1.00
AGING	regulates	gene	1.00
MITOPHAGY	activates	gene	1.00
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	1.00
MITOCHONDRIA	activates	gene	1.00
NEURODEGENERATION	associated_with	gene	1.00
ROS	therapeutic_target	gene	1.00
CYTOKINES	activates	gene	1.00
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	1.00
AGING	activates	gene	1.00
P53	activates	gene	1.00
CANCER	associated_with	gene	1.00
AGING	inhibits	gene	1.00
INFLAMMATION	causes	gene	1.00
CANCER	expressed_in	gene	1.00
INFLAMMATION	therapeutic_target	gene	1.00
MITOCHONDRIAL DNA	associated_with	gene	1.00
CANCER	activates	gene	1.00
NEURODEGENERATION	causes	gene	1.00
APOPTOSIS	inhibits	gene	1.00
TP53	associated_with	gene	1.00
GENES	associated_with	gene	1.00
CANCER	therapeutic_target	gene	1.00
AGING	associated_with	gene	1.00
INFLAMMATION	activates	gene	1.00
INFLAMMATION	associated_with	gene	1.00
MTDNA	associated_with	gene	1.00
TBK1	activates	gene	1.00
BAX	activates	gene	1.00
AUTOPHAGY	regulates	gene	1.00
GENES	inhibits	gene	1.00
STAT3	inhibits	gene	1.00
INFLAMMATION	regulates	gene	1.00
MITOCHONDRIA	associated_with	gene	1.00
NEURODEGENERATION	activates	gene	1.00
ALZHEIMER	therapeutic_target	gene	1.00
ALZHEIMER	associated_with	gene	1.00
EGFR	therapeutic_target	gene	1.00
FERROPTOSIS	activates	gene	1.00
DSDNA	activates	gene	1.00
MITOCHONDRIAL DYSFUNCTION	causes	gene	1.00
APOPTOSIS	regulates	gene	1.00
ALZHEIMER'S DISEASE	therapeutic_target	gene	1.00
OXIDATIVE STRESS	causes	gene	1.00
AGING	therapeutic_target	gene	1.00

Targeting Hypotheses (18)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Re	0.804	neurodegeneration	What are the mechanisms by which gut mic
Mitochondrial DNA-Driven AIM2 Inflammasome Activation in Neu	0.803	neurodegeneration	What are the mechanisms by which gut mic
Senescent Cell Mitochondrial DNA Release	0.742	neurodegeneration	Senolytic therapy for age-related neurod
Temporal CAG Repeat Stabilization via CRISPR-Mediated DNA Mi	0.681	neurodegeneration	CRISPR-based therapeutic approaches for
Oligodendrocyte DNA Repair Enhancement Therapy	0.665	neurodegeneration	Cell type vulnerability in Alzheimer's D

PARP1 Inhibition Blocks Poly(PR)-Triggered DNA Damage and Su	0.661	neurodegeneration	What upstream mechanisms trigger p53 act
Neuronal TET1 Upregulation Reactivates Immediate-Early Genes	0.640	neurodegeneration	epigenetic reprogramming aging neurons
TREM2 Promoter Silencing via DNA Hypermethylation	0.580	developmental neurobiology	Do perinatal immune challenges create pe
Oligodendrocyte DNA Repair Enhancement	0.550	neurodegeneration	Cell type vulnerability in Alzheimers Di
HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor	0.544	neurodegeneration	Protein aggregation cross-seeding across
Telomere Attrition and DNA Damage Response Activation Induce	0.520	neurodegeneration	What molecular mechanisms drive microgli
Severely Depleted mtDNA and Impaired OXPHOS Defines Senescen	0.520	neurodegeneration	How can senescent microglia be molecular
Mitochondrial DNA Damage and cGAS-STING Activation Induces M	0.520	neurodegeneration	What molecular mechanisms drive microgli
Targeted DNA Demethylation at the Klotho Locus via dCas9-TET	0.510	neurodegeneration	epigenetic reprogramming aging neurons
DNA Methylation Clock Drift at Glial Promoters	0.480	neurodegeneration	Comparative epigenetic signatures: DNA m
DNA Hypomethylation at P2RY12 Promoter Correlates with Disea	0.440	neurodegeneration	What determines P2RY12 receptor expressi
DNA Damage Repair Dysfunction Creating TDP-43 Pathology Feed	0.430	neurodegeneration	How does APOE4 mechanistically increase
TET Enzyme Enhancement to Prevent Aberrant DNA Methylation	0.350	neurodegeneration	Comparative epigenetic signatures across

Mentioning Analyses (14)

Scientific analyses that reference this entity

Comparative epigenetic signatures: DNA methylation age acceleration and histone

neurodegeneration | 2026-04-18 | 7 hypotheses Top: 0.620

Comparative epigenetic signatures: DNA methylation age acceleration and histone

neurodegeneration | 2026-04-18 | 0 hypotheses

Comparative epigenetic signatures across AD, PD, and ALS

neurodegeneration | 2026-04-16 | 7 hypotheses Top: 0.550

Does DNAJB6 directly inhibit cross-seeding between tau, α-synuclein, and TDP-43

neurodegeneration | 2026-04-12 | 0 hypotheses

Do oligodendrocytes require DNA repair enhancement or inhibition for neuroprotec

neurodegeneration | 2026-04-11 | 0 hypotheses

Experiments (11)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Nation-wide NGS-based genetic screening of LGMD patients in US	exploratory	Limb-girdle muscular dystrophy	0.950	0.00	Human patients	proposed	N/A
iPSC-derived astrocyte-neuron co-culture mitochondrial transfer in PD	exploratory	Parkinson's disease	0.900	0.00	iPSC-derived dopaminergic neur	proposed	N/A
Proposed experiment from debate on Senolytics targeting p16/p21+ senes	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
Biomechanical Impact Profiles and Chronic Traumatic Encephalopathy Phe	clinical	Neurodegeneration	0.400	0.50	in_silico	proposed	$180,000
Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk Cohorts	clinical	ALS	0.400	0.50	human	proposed	$6,550,000
cGAS-STING Pathway Validation Study in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$7,100,000
Mixed Pathology Effects on Parkinson's Disease Progression and Treatme	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
NLRP3 Inflammasome Validation Study in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Regulated Necrosis Validation Study in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Senolytic Therapy (D+Q) Phase IIa Trial in Early Alzheimer's Disease	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Traumatic Brain Injury and Alzheimer's Disease Relationship	validation	Alzheimer's Disease	0.400	0.50	human	proposed	$3,000,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745]	Yu CH, Davidson S, Harapas CR, Hilton JB	Cell	2020	2
Past, present and future perspectives on the science of aging. [PMID:41566049]	Fabrisia Ambrosio; Maxim N Artyomov; Ste	Nature aging	2026	0
Overexpression of the ERG oncogene in prostate cancer identifies candidates for [PMID:41632544]	Köcher S, Elsesy ME, Moustafa A, Mohamma	J Clin Invest	2026	0
Mismatch repair MLH complexes make distinct contributions to post-replicative mi [PMID:41648604]	Casazza KM, Williams GM, Johengen L, Kel	bioRxiv	2026	0
Genetic variations in base excision repair genes and the risk of developing hepa [PMID:41844453]	Shao B, Yin H, Zhang S, He S, Lu H et al	Cancer Genet	2026	0
Parkinson's disease linked LRRK2 G2019S drives oxidative nuclear DNA damage and [PMID:41889852]	Liu J, Gonzalez-Hunt CP, Richbourg T, Ba	bioRxiv : the preprint server	2026	0
PARG inhibition sequesters nuclear PAR-binding proteins, including XRCC1 and its [PMID:41890038]	Dumoulin I, Lee BJ, Zhang C, Lin X, Wang	bioRxiv	2026	0
Function of HIF-1α in Regulation of Antioxidative Stress of Tribolium castaneum [PMID:41899005]	Wan Z, Li X, Wang Y, Miao S, Chen Z et a	Insects	2026	0
Versatile and sensitive detection of mono- and poly(ADP-ribosyl)ation reveals XR [PMID:41922367]	Dauben H, Mihaljević M, Kolvenbach A, Pa	Nat Commun	2026	0
DNAJB6: A guardian against neurodegeneration. [PMID:40536953]	Hentze J, Gelman A, Brudek T, Hansen C	Neural regeneration research	2026	0
Stimuli-responsive nanoplatforms for precision activation of the STING pathway i [PMID:41668757]	["Bi D", "Yang X", "Wang Y", "Yong J", "	Frontiers in immunology	2026	0
Decoding senescent drivers in Alzheimer's disease: From bench to bedside. [PMID:41344577]	["Zhou R", "Lin X", "Liao Z", "Lin J", "	Ageing research reviews	2026	0
Role of NEIL1 in genome maintenance. [PMID:40010204]	["McCullough A", "Minko I", "Luzadder M"	DNA repair	2025	0
Bionanoconjugates in Neurodegeneration: Peptide-Nanoparticle Alliances for Next- [PMID:41199078]	["Ranjitha V", "Kumar A", "Kaalappa P"]	Pharmaceutical research	2025	0
Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven imm [PMID:40203808]	["Lai P", "Liu L", "Bancaro N", "Troiani	Immunity	2025	0
Apheresis for senescence: Targeting the senescence-associated secretory phenotyp [PMID:40651559]	["Akgun Y"]	Ageing research reviews	2025	0
Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non- [PMID:41271702]	Resnick SJ, Qamar S, Krishna P, Korobeyn	Nature communications	2025	0
Methodological influences on circulating cell-free-mitochondrial and nuclear DNA [PMID:40080226]	["Daubermann C", "Herhaus B", "Neuberger	Molecular biology reports	2025	0
Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflamma [PMID:40902587]	["Song Z", "Xie X", "Chen Y", "Zhang B",	Immunity	2025	0
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746]	["Sanadgol N", "Abedi M", "Hashemzaei M"	Journal of nanobiotechnology	2025	0

Debates (18)

Multi-agent debates referencing this entity

While DNAJB1 enhancement showed promise, the debate raised concerns about whethe

closed · Rounds: 4 · Score: 0.73 · 2026-04-22

While the study establishes TDP-43 triggers mtDNA release via mPTP to activate c

closed · Rounds: 4 · Score: 0.73 · 2026-04-21

The study identifies cGAS/STING activation as a consequence of TDP-43-mediated m

closed · Rounds: 4 · Score: 0.73 · 2026-04-21

While the study demonstrates TDP-43 triggers mPTP-mediated mtDNA release, the mo

closed · Rounds: 4 · Score: 0.77 · 2026-04-21

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

closed · Rounds: 4 · Score: 0.50 · 2026-04-21

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

closed · Rounds: 0 · Score: 0.48 · 2026-04-21

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

closed · Rounds: 0 · Score: 0.51 · 2026-04-21

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

closed · Rounds: 4 · Score: 0.73 · 2026-04-21

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

closed · Rounds: 0 · Score: 0.52 · 2026-04-21

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

closed · Rounds: 0 · Score: 0.58 · 2026-04-21

Related Research

Hypotheses and analyses mentioning DNA in their description or question text

DNA

Understanding Entity Pages

Summary

Wiki Pages (21)

DNA Damage Response in Parkinson's Disease

DNA Damage Response in Corticobasal Syndrome

DNA Damage Response Impairment Pathway

DNAJC13 — DnaJ Heat Shock Protein Family Member C13

DNA Damage Response in Alzheimer's Disease

DNA Sensing Pathways in Neurodegeneration

PRIMPOL — DNA Primase/Polymerase

TAR DNA-Binding Protein 43 (TDP-43)

POLN Gene — DNA Polymerase Nu

DNA Damage Response in Corticobasal Syndrome

ZBP1 (Z-DNA Binding Protein 1)

Huntington's Disease Somatic CAG Expansion and DNA Repair

DNA-PKcs (PRKDC) Protein

Mitochondrial DNA Mutations in Neurodegeneration

DNAJB5 (DnaJ Heat Shock Protein Family Member B5)

POLG2 Gene — DNA Polymerase Gamma 2, Accessory Subunit

CBS DNA Damage Response Mechanisms

POLG — DNA Polymerase Subunit Gamma

LIG3 Protein — DNA Ligase III

TDP-43 (TAR DNA-Binding Protein 43) - Biomarker

cGAS-STING Cytosolic DNA Sensing Pathway in Neurodegeneration

Pathway Diagram

Outgoing (3291)

Incoming (1991)

Targeting Hypotheses (18)

Mentioning Analyses (14)

Comparative epigenetic signatures: DNA methylation age acceleration and histone

Comparative epigenetic signatures: DNA methylation age acceleration and histone

Comparative epigenetic signatures across AD, PD, and ALS

Does DNAJB6 directly inhibit cross-seeding between tau, α-synuclein, and TDP-43

Do oligodendrocytes require DNA repair enhancement or inhibition for neuroprotec

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

What determines the specificity of DDR protein recruitment to dilncRNA-induced c

How do dilncRNAs specifically drive molecular crowding and phase separation of D

What upstream mechanisms cause TDP-43 to trigger mPTP opening and can this be th

How does chronic cGAS/STING activation downstream of TDP-43 contribute to progre

What determines the specificity of TDP-43-induced mitochondrial DNA release for

Can chaperone enhancement approaches overcome tau seed saturation effects in adv

Epigenetic reprogramming in aging neurons

Experiments (11)

Related Papers (20)

Debates (18)

While DNAJB1 enhancement showed promise, the debate raised concerns about whethe

While the study establishes TDP-43 triggers mtDNA release via mPTP to activate c

The study identifies cGAS/STING activation as a consequence of TDP-43-mediated m

While the study demonstrates TDP-43 triggers mPTP-mediated mtDNA release, the mo

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Related Research

PARP1 Inhibition Blocks Poly(PR)-Triggered DNA Damage and Subsequent p53 Activat

Neuronal TET1 Upregulation Reactivates Immediate-Early Genes and Restores Dendri

TREM2 Promoter Silencing via DNA Hypermethylation

Oligodendrocyte DNA Repair Enhancement

HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor

Telomere Attrition and DNA Damage Response Activation Induces Microglial Senesce

Severely Depleted mtDNA and Impaired OXPHOS Defines Senescent Microglia

Mitochondrial DNA Damage and cGAS-STING Activation Induces Microglial Senescence

Targeted DNA Demethylation at the Klotho Locus via dCas9-TET1 Rescues Neuroprote

DNA Methylation Clock Drift at Glial Promoters

DNA Hypomethylation at P2RY12 Promoter Correlates with Disease Progression

DNA Damage Repair Dysfunction Creating TDP-43 Pathology Feed-Forward Loop

TET Enzyme Enhancement to Prevent Aberrant DNA Methylation