pathway

autophagy pathway

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about autophagy pathway: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

971Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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🔀 Pathway Info

Name	autophagy pathway
Key Genes/Proteins	ABCA1, ABCB1, ABCD3, ABCG1, ABCG2, ABL1
Linked Hypotheses	1 hypotheses

Pathway Diagram

graph TD
    autophagy_pathway["autophagy pathway"] -->|"active in"| neurons["neurons"]
    style neurons fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    autophagy_pathway["autophagy pathway"] -->|"protects against"| Neuronal_Health["Neuronal Health"]
    style Neuronal_Health fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    autophagy_pathway["autophagy pathway"] -->|"mediates"| ferroptosis["ferroptosis"]
    style ferroptosis fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    autophagy_pathway["autophagy pathway"] -->|"mediates"| phagocytosis["phagocytosis"]
    style phagocytosis fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    autophagy_pathway["autophagy pathway"] -->|"active in"| endothelial_cells["endothelial cells"]
    style endothelial_cells fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    autophagy_pathway["autophagy pathway"] -->|"mediates"| protein_misfolding["protein misfolding"]
    style protein_misfolding fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    autophagy_pathway["autophagy pathway"] -->|"mediates"| ER_stress["ER stress"]
    style ER_stress fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    OPTN["OPTN"] -->|"regulates"| autophagy_pathway["autophagy pathway"]
    style OPTN fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    MTOR["MTOR"] -->|"participates in"| autophagy_pathway["autophagy pathway"]
    style MTOR fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    MTORC1["MTORC1"] -->|"participates in"| autophagy_pathway["autophagy pathway"]
    style MTORC1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    SQSTM1["SQSTM1"] -->|"participates in"| autophagy_pathway["autophagy pathway"]
    style SQSTM1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    PI3K["PI3K"] -->|"participates in"| autophagy_pathway["autophagy pathway"]
    style PI3K fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style autophagy_pathway fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (80)

Target	Relation	Type	Str
h-0a83fc12c7	targeted_by	hypothesis	1.00
neural stem cells	active_in	cell_type	0.90
neurons	active_in	cell_type	0.90
ferroptosis	mediates	process	0.90
phagocytosis	mediates	process	0.90
Neuronal Health	protects_against	phenotype	0.90
Neurodegeneration	associated_with	disease	0.85
Autophagosome Biogenesis	regulates	process	0.85
endothelial cells	active_in	cell_type	0.80
ER stress	mediates	process	0.80
protein misfolding	mediates	process	0.80
necroptosis	mediates	process	0.70
lysosomal dysfunction	mediates	process	0.70
unfolded protein response	crosstalk_with	pathway	0.70
NEURON	regulates	cell_type	0.65
CGAS	inhibits	gene	0.65
BECN1	activates	gene	0.65
TAU	treats	protein	0.65
nucleus accumbens	active_in	brain_region	0.60
ubiquitin-proteasome	crosstalk_with	pathway	0.60
oxidative stress response	crosstalk_with	pathway	0.60
calcium signaling	mediates	process	0.60
necroptosis	crosstalk_with	pathway	0.60
blood-brain barrier	active_in	brain_region	0.60
monocytes	active_in	cell_type	0.60
microglia	active_in	cell_type	0.60
dendritic cells	active_in	cell_type	0.60
insulin signaling	crosstalk_with	pathway	0.60
complement cascade	crosstalk_with	pathway	0.60
cGAS-STING	crosstalk_with	pathway	0.60
cerebellum	active_in	brain_region	0.60
mitochondrial dynamics	crosstalk_with	pathway	0.60
macrophages	active_in	cell_type	0.60
lipid metabolism	crosstalk_with	pathway	0.60
ferroptosis	crosstalk_with	pathway	0.60
INFLAMMATION	associated_with	phenotype	0.45
ROS	associated_with	phenotype	0.45
NEURON	associated_with	cell_type	0.45
ALPHA-SYNUCLEIN	associated_with	protein	0.45
MACROPHAGES	associated_with	cell_type	0.45
MACROPHAGE	associated_with	cell_type	0.45
MITOPHAGY	associated_with	phenotype	0.45
SENESCENCE	associated_with	phenotype	0.45
AMPK	associated_with	gene	0.45
ER STRESS	associated_with	phenotype	0.45
AGING	associated_with	phenotype	0.45
AUTOPHAGY	associated_with	phenotype	0.45
PARKIN	associated_with	gene	0.45
PINK1	associated_with	gene	0.45
ULK1	associated_with	gene	0.45

Incoming (891)

Source	Relation	Type	Str
h-0a83fc12c7	targets	hypothesis	1.00
Autophagosome	involved_in	process	0.95
TFEB	participates_in	gene	0.90
P62	links	protein	0.90
AMBRA1	participates_in	gene	0.90
PRKN	participates_in	gene	0.90
ATG8	participates_in	gene	0.90
GABARAP	participates_in	gene	0.90
OPTN	regulates	protein	0.90
TNF	participates_in	gene	0.90
NLR	participates_in	gene	0.90
PI3K-AKT-mTOR signaling	crosstalk_with	pathway	0.90
RB1CC1	participates_in	gene	0.90
BNIP3	participates_in	gene	0.90
BCL2	participates_in	gene	0.90
AMPK	participates_in	gene	0.90
LC3B	participates_in	gene	0.90
GPX4	participates_in	gene	0.90
AKT	participates_in	gene	0.90
VAMP8	participates_in	gene	0.90
PINK1	participates_in	gene	0.90
LC3	participates_in	gene	0.90
NLRP3	participates_in	gene	0.90
APP	participates_in	gene	0.90
GFP	participates_in	gene	0.90
CALCOCO2	participates_in	gene	0.90
LAMP2	participates_in	gene	0.90
RUBCNL	participates_in	gene	0.90
AR	participates_in	gene	0.90
SNAP29	participates_in	gene	0.90
neurodegeneration	involves	disease	0.90
MTORC1	participates_in	gene	0.90
SQSTM1	participates_in	gene	0.90
LRRK2	involved_in	protein	0.90
MTOR	participates_in	gene	0.90
PI3K	participates_in	gene	0.90
PRESENILIN	regulates	protein	0.88
DAM microglia	active_in	cell_type	0.85
rapamycin	modulates	drug	0.85
neurons	active_in	cell_type	0.85
trehalose	modulates	drug	0.85
OPTN	participates_in	gene	0.80
BECN1	participates_in	gene	0.80
CASP1	participates_in	gene	0.80
MAP1LC3	participates_in	gene	0.80
FOXO3	participates_in	gene	0.80
IL1B	participates_in	gene	0.80
ROS	participates_in	gene	0.80
ATG4B	participates_in	gene	0.80
ULK1	participates_in	gene	0.80

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Dendritic tau missorting persists through local proteostatic	0.530	neurodegeneration	Does tau dendritic missorting persist in

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning autophagy pathway in their description or question text

No additional research found