disease

ATHEROSCLEROSIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATHEROSCLEROSIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2105Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

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Disease Info

Associated Genes	APP, BMAL1, HIF1A, LDLR
Therapeutic Agents	CURCUMIN
KG Connections	222 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Pathway Diagram

graph TD
    ATHEROSCLEROSIS["ATHEROSCLEROSIS"] -->|"promotes"| MACROPHAGE["MACROPHAGE"]
    style MACROPHAGE fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    ATHEROSCLEROSIS["ATHEROSCLEROSIS"] -->|"promotes"| MACROPHAGES["MACROPHAGES"]
    style MACROPHAGES fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    ATHEROSCLEROSIS["ATHEROSCLEROSIS"] -->|"causes"| ENDOTHELIAL["ENDOTHELIAL"]
    style ENDOTHELIAL fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    ATHEROSCLEROSIS["ATHEROSCLEROSIS"] -->|"promotes"| PI3K["PI3K"]
    style PI3K fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    ATHEROSCLEROSIS["ATHEROSCLEROSIS"] -.->|"reduces"| INFLAMMATION["INFLAMMATION"]
    style INFLAMMATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    ATHEROSCLEROSIS["ATHEROSCLEROSIS"] -.->|"reduces"| LDLR["LDLR"]
    style LDLR fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    ATHEROSCLEROSIS["ATHEROSCLEROSIS"] -->|"expressed in"| DIABETES["DIABETES"]
    style DIABETES fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    C1Q["C1Q"] -->|"associated"| ATHEROSCLEROSIS["ATHEROSCLEROSIS"]
    style C1Q fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    C1QA["C1QA"] -->|"associated"| ATHEROSCLEROSIS["ATHEROSCLEROSIS"]
    style C1QA fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    C1QC["C1QC"] -->|"associated"| ATHEROSCLEROSIS["ATHEROSCLEROSIS"]
    style C1QC fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    MACROPHAGE_1["MACROPHAGE"] -->|"contributes to"| ATHEROSCLEROSIS["ATHEROSCLEROSIS"]
    style MACROPHAGE_1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    APOE["APOE"] -->|"associated"| ATHEROSCLEROSIS["ATHEROSCLEROSIS"]
    style APOE fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ATHEROSCLEROSIS fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (597)

Target	Relation	Type	Str
Inflammation	causes	disease	1.00
Inflammation	inhibits	disease	1.00
Inflammation	therapeutic_target	disease	1.00
Inflammation	contributes_to	disease	1.00
Senescence	associated_with	disease	1.00
Inflammation	associated_with	disease	1.00
Inflammasome	activates	pathway	1.00
Lipid Metabolism	regulates	pathway	1.00
Cholesterol	regulates	pathway	1.00
Inflammation	activates	disease	1.00
Cholesterol	inhibits	pathway	1.00
Mtor	therapeutic_target	pathway	1.00
Microrna	regulates	pathway	1.00
Oxidative Stress	activates	pathway	1.00
Lipid Metabolism	associated_with	pathway	1.00
Cardiovascular Morbidity And Mortality	causes	phenotype	0.95
Cardiovascular Disease	causes	disease	0.95
Cardiovascular Diseases	causes	disease	0.95
Vascular Remodelling	associated_with	process	0.95
Inflammation	implicated_in	disease	0.95
Alzheimer'S Disease	risk_factor_for	disease	0.95
Cholesterol	associated_with	pathway	0.95
Stroke	risk_factor_for	disease	0.90
Coronary Artery Disease	causes	disease	0.90
Cholesterol	activates	pathway	0.90
Autophagy	activates	pathway	0.90
Mtor	activates	pathway	0.90
Nf-Κb	inhibits	pathway	0.90
Oxidative Stress	treats	pathway	0.90
Lipid Metabolism	therapeutic_target	pathway	0.90
Epigenetic	therapeutic_target	pathway	0.90
Oxidative Stress	therapeutic_target	pathway	0.90
Lipid Metabolism	activates	pathway	0.90
Cardiovascular	associated_with	disease	0.85
Vascular Brain Injury	causes	process	0.85
Cardiovascular	therapeutic_target	disease	0.85
Heart Failure	causes	disease	0.85
Cardiovascular	activates	disease	0.85
Alzheimer's Disease	risk_factor_for	disease	0.80
MACROPHAGES	activates	cell_type	0.80
Cholesterol	therapeutic_target	pathway	0.80
Immune Response	therapeutic_target	pathway	0.80
Autophagy	therapeutic_target	pathway	0.80
Nf-Κb	therapeutic_target	pathway	0.80
Differentiation	regulates	pathway	0.80
Angiogenesis	regulates	pathway	0.80
Mtor	inhibits	pathway	0.80
Differentiation	implicated_in	pathway	0.80
Toll-Like Receptor	activates	pathway	0.80
Mapk	therapeutic_target	pathway	0.80

Incoming (1508)

Source	Relation	Type	Str
LDL	activates	gene	1.00
NF-ΚB	inhibits	gene	1.00
Als	regulates	disease	1.00
CYTOKINES	activates	gene	1.00
LDL	inhibits	gene	1.00
GENES	therapeutic_target	gene	1.00
Als	activates	disease	1.00
GENES	regulates	gene	1.00
Als	therapeutic_target	disease	1.00
APOE	associated_with	gene	1.00
APOE	inhibits	gene	1.00
INFLAMMATION	activates	gene	1.00
INFLAMMATION	inhibits	gene	1.00
MICRORNAS	regulates	gene	1.00
INFLAMMATION	causes	gene	1.00
INFLAMMATION	associated_with	gene	1.00
CANCER	associated_with	gene	1.00
Aging	associated_with	disease	1.00
INFLAMMATION	contributes_to	gene	1.00
INFLAMMATION	implicated_in	gene	1.00
AGING	activates	gene	1.00
Cancer	associated_with	disease	1.00
APOE	activates	gene	1.00
AGING	associated_with	gene	1.00
INFLAMMATION	therapeutic_target	gene	1.00
OXIDATIVE STRESS	activates	gene	1.00
Diabetes	associated_with	disease	1.00
Cardiovascular	associated_with	disease	1.00
Als	associated_with	disease	1.00
OXIDATIVE STRESS	therapeutic_target	gene	1.00
SPP1	contributes_to	protein	0.95
Shexiang Baoxin Pill	protects_against	drug	0.95
AUTOPHAGY	activates	gene	0.95
INFLAMMATION	regulates	gene	0.95
Stroke	associated_with	disease	0.95
S1P1	protects_against	receptor	0.95
GENES	associated_with	gene	0.95
CYTOKINES	therapeutic_target	gene	0.95
GENES	activates	gene	0.95
Bap	associated_with	compound	0.95
STROKE	associated_with	gene	0.95
Inflammation	promotes	process	0.95
MTOR	therapeutic_target	gene	0.95
Cardiac	associated_with	disease	0.95
SBP	protects_against	drug	0.95
APOE	therapeutic_target	gene	0.95
C1Q	risk_factor_for	gene	0.95
Cigarette Smoking	causes	drug	0.95
MTOR	activates	gene	0.95
Cardiovascular	therapeutic_target	disease	0.95

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does SPI1 transcriptionally regulate C1QA and C1QC expression in atheroscler

neuroinflammation | 2026-04-08 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The authors identify SPI1 as a potential transcription factor regulating the hub

closed · Rounds: 4 · Score: 0.93 · 2026-04-09