gene

AKT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AKT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1557Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

AKT1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, therapeutic target, activates. Associated with ALS, Aging, Als. Connected to 765 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	AKT1
Protein Type	Kinase
Function	is a serine/threonine protein kinase that serves as a central hub in the PI3K/AKT/mTOR signaling pathway, one of the most critical survival and growth signaling cascades in neurons.
Amino Acids	480 aa
Pathways	Akt, Apoptosis, Autophagy, Immune Response, Mapk
Ensembl ID	ENSG00000142208
GeneCards	AKT1
Human Protein Atlas	AKT1
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	Andrographis paniculata, Atbc, berberine, Coumestrol, COUMESTROL, DEP
Interactions	ACTB, Actin, AGING, AKT, ALZHEIMER, ALZHEIMER DISEASE
KG Connections	1557 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    AKT1(["AKT1"])
    Cancer["Cancer"]
    Als["Als"]
    CANCER(["CANCER"])
    AKT(["AKT"])
    TP53(["TP53"])
    Pi3K_Akt["Pi3K/Akt"]
    GENES(["GENES"])
    TNF(["TNF"])
    IL6(["IL6"])
    PI3K(["PI3K"])
    Aerobic_Glycolysis("Aerobic Glycolysis")
    Lysosomal_Synapse_Formation("Lysosomal Synapse Formation")
    PIK3CA(["PIK3CA"])
    SLC2A1(["SLC2A1"])
    HK2["HK2"]

    AKT1 -->|"therapeutic target"| Cancer
    AKT1 -->|"therapeutic target"| Als
    AKT1 -->|"therapeutic target"| CANCER
    AKT1 -->|"therapeutic target"| AKT
    AKT1 -->|"therapeutic target"| TP53
    AKT1 -->|"therapeutic target"| Pi3K_Akt
    AKT1 -->|"therapeutic target"| GENES
    TNF -->|"therapeutic target"| AKT1
    AKT1 -->|"therapeutic target"| IL6
    AKT1 -->|"therapeutic target"| PI3K
    AKT1 -->|"associated with"| Aerobic_Glycolysis
    AKT1 -->|"modulates"| Lysosomal_Synapse_Formation
    PIK3CA -->|"activates"| AKT1
    AKT1 -->|"phosphorylates"| SLC2A1
    AKT1 -->|"phosphorylates"| HK2

    style AKT1 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (1088)

Target	Relation	Type	Str
AKT	therapeutic_target	gene	1.00
GENES	therapeutic_target	gene	1.00
TP53	targets	gene	1.00
Pi3K/Akt	therapeutic_target	pathway	1.00
CANCER	therapeutic_target	gene	1.00
Als	therapeutic_target	disease	1.00
Cancer	therapeutic_target	disease	1.00
IL6	targets	gene	1.00
PI3K	targets	gene	1.00
Lysosomal Synapse Formation	modulates	process	0.95
Aerobic Glycolysis	associated_with	process	0.95
PI3K	associated_with	gene	0.92
autophagy	activates	process	0.92
aerobic glycolysis	promotes	process	0.90
GSK3B	inhibits	gene	0.90
Colorectal Cancer	associated_with	disease	0.90
Breast Cancer	involved_in	disease	0.90
SLC2A1	phosphorylates	gene	0.90
TNF	targets	gene	0.90
breast cancer	risk_factor_for	disease	0.90
protein synthesis	upregulates	process	0.90
Apoptosis	therapeutic_target	pathway	0.90
IL-6	therapeutic_target	gene	0.90
Mapk	therapeutic_target	pathway	0.90
PI3K	inhibits	gene	0.90
STAT3	targets	gene	0.90
JUN	targets	gene	0.90
CASP3	targets	gene	0.90
EGFR	targets	gene	0.90
VEGFA	targets	gene	0.90
Pi3K/Akt/Mtor Pathway	involved_in	pathway	0.88
Carcinoma	activates	disease	0.85
Lysosomal Synapses	modulates	process	0.85
Bladder Cancer Metabolism	regulates	phenotype	0.85
solar dermatitis	therapeutic_target	disease	0.85
Fibrosis	therapeutic_target	disease	0.85
Insomnia	therapeutic_target	disease	0.85
Osteoclast Differentiation	regulates	process	0.85
TNF Signaling Pathway	involved_in	pathway	0.85
FOXO1	inhibits	gene	0.85
Als	treats	disease	0.85
Inflammation	therapeutic_target	disease	0.85
niche formation	activates	process	0.85
Tumor	therapeutic_target	disease	0.85
FOXO1	regulates	protein	0.85
HIF1A	regulates	protein	0.85
GSK3B	phosphorylates	protein	0.85
Hyperthyroidism	associated_with	disease	0.85
Cancer	inhibits	disease	0.85
Cancer	activates	disease	0.85

Incoming (469)

Source	Relation	Type	Str
TNF	therapeutic_target	gene	1.00
TBEV prM	interacts_with	protein	0.95
PIK3CA	activates	gene	0.95
SBP	downregulates	drug	0.90
DMP	binds	compound	0.90
Berberine	binds_to	drug	0.90
prM	interacts_with	protein	0.90
PDK1	phosphorylates	gene	0.90
Piperine	binds_to	drug	0.90
PET-MPs	binds_to	drug	0.88
Hyperthyroidism	upregulates	disease	0.85
DEP	binds	compound	0.85
BDNF	interacts_with	gene	0.85
Pinghe Sleep Aromatherapy Product	targets	drug	0.85
Ipatasertib	inhibits	drug	0.85
Atbc	binds	compound	0.85
Coumestrol	binds	compound	0.85
RLN	phosphorylates	protein	0.85
GPR39	activates	receptor	0.85
Andrographis paniculata	modulates	drug	0.80
Cholix	phosphorylates	entity	0.80
Transcranial near-infrared light	activates	compound	0.80
Kudzu Root	regulates	drug	0.80
APOPTOSIS	inhibits	gene	0.80
Gap26	upregulates	compound	0.75
AKT	inhibits	gene	0.70
TNF	interacts_with	gene	0.70
BAX	inhibits	gene	0.70
PI3K	inhibits	gene	0.70
RPS6	activates	gene	0.70
APOPTOSIS	activates	gene	0.70
APOPTOSIS	therapeutic_target	gene	0.70
CASP3	interacts_with	gene	0.70
PI3K	therapeutic_target	gene	0.70
AKT	targets	gene	0.70
COUMESTROL	interacts_with	drug	0.64
ABCG2	therapeutic_target	gene	0.60
SLC6A4	therapeutic_target	gene	0.60
DRD2	associated_with	gene	0.60
GABRA2	therapeutic_target	gene	0.60
MAOA	therapeutic_target	gene	0.60
JAK2	interacts_with	gene	0.60
JNK	therapeutic_target	gene	0.60
PICK1	interacts_with	gene	0.60
APP	therapeutic_target	gene	0.60
CXCL8	therapeutic_target	gene	0.60
CDK5	activates	gene	0.60
HSP90	therapeutic_target	gene	0.60
CNR1	therapeutic_target	gene	0.60
ROS	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning AKT1 in their description or question text

No additional research found