gene

NLR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NLR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1135Connections

21Hypotheses

1Analyses

50Outgoing

50Incoming

4Experiments

1Debates

Summary

Page for NLR Family Member X1

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🧬 Gene Info

Gene Symbol	NLR
Primary Expression	substantia nigra, Substantia Nigra
Amino Acids	977 aa
Pathways	NF-κB
GeneCards	NLR
Human Protein Atlas	NLR
Associated Diseases	Als, Alzheimer, Cancer, Cardiovascular, dementia
Known Drugs/Compounds	dimethyl fumarate, rapamycin
Interactions	ABCD3, ABP, ACTB, Actin, AGING, AIF1
KG Connections	1135 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    NLR["NLR"]
    Alzheimer["Alzheimer"]
    Cardiovascular["Cardiovascular"]
    Parkinson["Parkinson"]
    Dementia["Dementia"]
    Frontotemporal_Dementia["Frontotemporal Dementia"]
    Cancer["Cancer"]
    Fibrosis["Fibrosis"]
    Neurodegeneration["Neurodegeneration"]
    Aging["Aging"]
    Tumor["Tumor"]
    ALS["ALS"]
    Inflammation["Inflammation"]
    Neuroinflammation["Neuroinflammation"]
    NLR <-->|"interacts"| Alzheimer
    NLR <-->|"interacts"| Cardiovascular
    NLR <-->|"interacts"| Parkinson
    NLR <-->|"interacts"| Dementia
    NLR <-->|"interacts"| Frontotemporal_Dementia
    NLR <-->|"interacts"| Cancer
    NLR <-->|"interacts"| Fibrosis
    NLR -.->|"inhibits"| Neurodegeneration
    NLR -.->|"inhibits"| Parkinson
    NLR -.->|"inhibits"| Aging
    NLR -->|"regulates"| Tumor
    NLR -.->|"inhibits"| ALS
    NLR -.->|"inhibits"| Inflammation
    NLR -.-|"associated"| Tumor
    NLR -->|"activates"| Inflammation
    NLR -->|"activates"| Neurodegeneration
    NLR -->|"activates"| Neuroinflammation
    NLR -->|"activates"| Parkinson
    NLR -->|"activates"| Tumor
    NLR -->|"activates"| ALS
    style NLR fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (612)

Target	Relation	Type	Str
autophagy pathway	participates_in	pathway	0.90
oxidative stress response	participates_in	pathway	0.90
pyroptosis	participates_in	pathway	0.90
microglia	activates	cell_type	0.80
ROS	regulates	gene	0.80
neural stem cells	regulates	cell_type	0.80
OPTN	regulates	gene	0.80
neural stem cells	activates	cell_type	0.80
ROS	activates	gene	0.80
necroptosis	participates_in	pathway	0.80
SQSTM1	activates	gene	0.80
MAPK signaling	participates_in	pathway	0.80
ubiquitin-proteasome	participates_in	pathway	0.80
RB1	activates	gene	0.70
PI3K-AKT-mTOR signaling	participates_in	pathway	0.70
NRBF2	activates	gene	0.70
RIPK3	activates	gene	0.70
stem cells	expressed_in	cell_type	0.70
STAT3	activates	gene	0.70
OPTN	activates	gene	0.70
STING1	activates	gene	0.70
Alzheimer's disease	activates	disease	0.70
RB1CC1	activates	gene	0.70
PI3K	activates	gene	0.70
microglia	expressed_in	cell_type	0.70
JAK-STAT signaling	participates_in	pathway	0.70
endothelial cells	activates	cell_type	0.70
neurodegeneration	disrupts	disease	0.70
RB1	regulates	gene	0.70
NLRP3	causes	gene	0.70
PI3K	regulates	gene	0.70
NLRP3	disrupts	gene	0.70
PRKN	regulates	gene	0.70
RB1CC1	regulates	gene	0.70
RIPK3	regulates	gene	0.70
PTEN	regulates	gene	0.70
PINK1	regulates	gene	0.70
dendritic cells	activates	cell_type	0.70
dendritic cells	regulates	cell_type	0.70
unfolded protein response	participates_in	pathway	0.70
macrophages	expressed_in	cell_type	0.70
STING1	regulates	gene	0.70
PYCARD	activates	gene	0.70
STAT3	regulates	gene	0.70
Neuroinflammation	expressed_in	disease	0.65
Inflammation	expressed_in	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Pyroptosis	expressed_in	disease	0.65
Pyroptosis	activates	disease	0.65

Incoming (523)

Source	Relation	Type	Str
ERN1	regulates	gene	0.80
LC3	regulates	gene	0.80
NBR1	regulates	gene	0.80
ERN1	activates	gene	0.80
LC3	activates	gene	0.80
rapamycin	targets	drug	0.80
NBR1	activates	gene	0.70
JNK	activates	gene	0.70
MAPK	activates	gene	0.70
MTOR	activates	gene	0.70
EIF2AK3	activates	gene	0.70
DNA	activates	gene	0.70
DDIT3	activates	gene	0.70
BECN1	activates	gene	0.70
FIP200	activates	gene	0.70
ATP	activates	gene	0.70
ATG	activates	gene	0.70
EIF2AK3	regulates	gene	0.70
DNA	regulates	gene	0.70
FIP200	regulates	gene	0.70
BCL2	regulates	gene	0.70
MTOR	regulates	gene	0.70
JNK	regulates	gene	0.70
DDIT3	regulates	gene	0.70
ATP	regulates	gene	0.70
CALCOCO2	regulates	gene	0.70
NDP52	regulates	gene	0.70
MAPK	regulates	gene	0.70
MAP1LC3	regulates	gene	0.70
ATG	regulates	gene	0.70
ACTB	inhibits	gene	0.60
ATG7	inhibits	gene	0.60
PARKINSON	inhibits	gene	0.60
SQSTM1	regulates	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
NLRP3	inhibits	gene	0.60
PPAR	activates	gene	0.60
CANCER	activates	gene	0.60
PRKN	activates	gene	0.60
MICROGLIA	activates	gene	0.60
DJ-1	activates	gene	0.60
TNF	activates	gene	0.60
SNCA	activates	gene	0.60
CCDC50	activates	gene	0.60
IRGM1	activates	gene	0.60
ALS	regulates	gene	0.60
AMBRA1	regulates	gene	0.60
AMPK	regulates	gene	0.60
BAX	activates	gene	0.60
GSH	activates	gene	0.60

Targeting Hypotheses (21)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming	0.888	neurodegeneration	What are the mechanisms by which gut mic
Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-S	0.822	neurodegeneration	What are the mechanisms by which gut mic
NLRP3 Inhibition (H7): Downstream Inflammatory Reversal	0.780	neurodegeneration	Does restoring neuronal AMPK activity re
NLRP3 Inflammasome Lock Perpetuates Senescence-Associated In	0.720	neurodegeneration	What molecular mechanisms drive microgli
Galectin-3 deletion attenuates NLRP3 inflammasome activation	0.650	neuroscience	Lysosomal dysfunction and cathepsin leak

NLRP3/Mitophagy Coupling Modulation	0.646	Neuroinflammation	Immune atlas neuroinflammation analysis
C1Q-Triggered NLRP3 Inflammasome Assembly in Plaque Macropha	0.640	neuroinflammation	What are the specific molecular mechanis
Selective cathepsin B inhibition prevents cathepsin leakage-	0.620	neuroscience	Lysosomal dysfunction and cathepsin leak
LRP1/NLRP3/IL-1β Cascade Links Aβ Endocytosis to Inflammasom	0.617	neurodegeneration	How do perivascular cells specifically r
The most realistic translational use of physiological SCFAs	0.610	neurodegeneration	Do physiological concentrations of SCFAs
Intermittent HBOT (2.0 ATA, 60 min, 3x/week) suppresses NLRP	0.590	neurodegeneration	What are the optimal oxygen pressure, du
LAMP-2 replacement therapy prevents lysosomal membrane perme	0.580	neuroscience	Lysosomal dysfunction and cathepsin leak
CX3CR1-Negative Trem2-High Microglial Subset Mediates Female	0.570	neuroinflammation	How do regional, age, and sex-dependent
NLRP3 Inflammasome Chromatin Priming Through H3K27ac Accumul	0.566	developmental neurobiology	Do perinatal immune challenges create pe
NLRP3 Inflammasome Blockade as Upstream Intervention to Prev	0.566	neurodegeneration	Why have numerous phase 3 clinical trial
P2X7R PET Imaging for NLRP3 Inflammasome-Associated Priming	0.560	biomarkers	What biomarkers can reliably detect micr
Temporal NLRP3 Inhibition During SPP1-Driven Microglial Acti	0.551	neuroinflammation	What molecular mechanisms mediate SPP1-i
Physiological SCFAs may worsen alpha-synuclein pathology thr	0.550	neurodegeneration	Do physiological concentrations of SCFAs
Temporal NLRP3 Inhibition via SPP1-Mediated Mitophagy Enhanc	0.496	neuroinflammation	What molecular mechanisms mediate SPP1-i
TFEB-Mediated Lysosomal Biogenesis Enhancement for NLRP3 Inf	0.485	Neuroinflammation	Immune atlas neuroinflammation analysis
NLRP3 Inflammasome Suppression via Selective Caspase-1 Inhib	0.105	neurodegeneration	Neuroinflammation Biomarker Panel for Ea

Mentioning Analyses (1)

Scientific analyses that reference this entity

Lysosomal dysfunction and cathepsin leakage in Alzheimer disease progression

neuroscience | 2026-04-04 | 7 hypotheses Top: 0.680

Experiments (4)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
Molecular characterization of RBG-NLRP3 binding interaction	exploratory	atherosclerosis	0.900	purified proteins and molecula	proposed	N/A
Leukocyte gene expression analysis in COVID-19 patients	exploratory	COVID-19	0.900	human leukocytes from COVID-19	proposed	N/A
RBG effects on macrophage polarization and foam cell formation	exploratory	atherosclerosis	0.850	primary macrophages	proposed	N/A
Transcriptomic analysis of RBG effects on inflammatory gene expression	exploratory	atherosclerosis	0.800	ApoE-/- mice and cell cultures	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Lysosomal membrane permeabilization releasing cathepsins triggers NLRP3 inflamma

closed · Rounds: 4 · Score: 0.76 · 2026-04-22

Related Research

Hypotheses and analyses mentioning NLR in their description or question text

NLRP3/Mitophagy Coupling Modulation

Score: 0.646 · Neuroinflammation · 2026-04-12

## Mechanistic Overview NLRP3/Mitophagy Coupling Modulation starts from the claim that modulating NLRP3 within the disea

C1Q-Triggered NLRP3 Inflammasome Assembly in Plaque Macrophages

Score: 0.640 · neuroinflammation · 2026-04-21

**Molecular Mechanism and Rationale** The C1Q complement system component represents a critical bridge between innate i

Selective cathepsin B inhibition prevents cathepsin leakage-mediated NLRP3 infla

Score: 0.620 · neuroscience · 2026-04-22

## Mechanistic Overview Selective cathepsin B inhibition prevents cathepsin leakage-mediated NLRP3 inflammasome activati

LRP1/NLRP3/IL-1β Cascade Links Aβ Endocytosis to Inflammasome Activation and SPP

Score: 0.617 · neurodegeneration · 2026-04-22

**Molecular Mechanism and Rationale** The proposed LRP1/NLRP3/IL-1β cascade represents a critical mechanistic link betw

The most realistic translational use of physiological SCFAs is as an adjunct to

Score: 0.610 · neurodegeneration · 2026-04-24

Physiological SCFA elevation may generate a weak, context-dependent signal that is insufficient alone but could become b

Intermittent HBOT (2.0 ATA, 60 min, 3x/week) suppresses NLRP3 inflammasome and s

Score: 0.590 · neurodegeneration · 2026-04-25

This hypothesis proposes that HBOT reduces ROS-mediated NF-κB activation and NLRP3 inflammasome assembly, promoting anti

LAMP-2 replacement therapy prevents lysosomal membrane permeabilization and down

Score: 0.580 · neuroscience · 2026-04-22

## Mechanistic Overview LAMP-2 replacement therapy prevents lysosomal membrane permeabilization and downstream NLRP3 act

CX3CR1-Negative Trem2-High Microglial Subset Mediates Female Resilience via Estr

Score: 0.570 · neuroinflammation · 2026-04-22

## Mechanistic Overview CX3CR1-Negative Trem2-High Microglial Subset Mediates Female Resilience via Estrogen Receptor-al

NLRP3 Inflammasome Chromatin Priming Through H3K27ac Accumulation

Score: 0.566 · developmental neurobiology · 2026-04-21

## Mechanistic Overview NLRP3 Inflammasome Chromatin Priming Through H3K27ac Accumulation starts from the claim that mod

NLRP3 Inflammasome Blockade as Upstream Intervention to Prevent SASP Amplificati

Score: 0.566 · neurodegeneration · 2026-04-16

## Mechanistic Overview NLRP3 Inflammasome Blockade as Upstream Intervention to Prevent SASP Amplification starts from t

P2X7R PET Imaging for NLRP3 Inflammasome-Associated Priming

Score: 0.560 · biomarkers · 2026-04-22

## Mechanistic Overview P2X7R PET Imaging for NLRP3 Inflammasome-Associated Priming starts from the claim that modulatin

Temporal NLRP3 Inhibition During SPP1-Driven Microglial Activation Windows

Score: 0.551 · neuroinflammation · 2026-04-20

## Mechanistic Overview Temporal NLRP3 Inhibition During SPP1-Driven Microglial Activation Windows starts from the claim

Physiological SCFAs may worsen alpha-synuclein pathology through FFAR2/GPR43-NLR

Score: 0.550 · neurodegeneration · 2026-04-24

A key liability hypothesis is that low-range SCFA signaling can be receptor-biased toward inflammasome activation in sus

Temporal NLRP3 Inhibition via SPP1-Mediated Mitophagy Enhancement During Critica

Score: 0.496 · neuroinflammation · 2026-04-21

## Mechanistic Overview Temporal NLRP3 Inhibition via SPP1-Mediated Mitophagy Enhancement During Critical Neuroinflammat

TFEB-Mediated Lysosomal Biogenesis Enhancement for NLRP3 Inflammasome Regulation

Score: 0.485 · Neuroinflammation · 2026-04-21

## Mechanistic Overview TFEB-Mediated Lysosomal Biogenesis Enhancement for NLRP3 Inflammasome Regulation starts from the

NLR

Understanding Entity Pages

Summary

Wiki Pages (20)

NLRP3 Inflammasome Activation Pathway in Neurodegeneration

NLRP3 Inflammasome Hypothesis in Parkinson's Disease

NLRP3 Inflammasome Pathway in Neurodegeneration

NLRP3 Senomorphic Cycling Therapy

NLRP3 Inflammasome Inhibitors for Parkinson's Disease

NLRC5 — NLR Family CARD Domain Containing 5

NLRP7 — NLR Family Pyrin Domain Containing 7

NLRP3-Coupled Senomorphic Cycling Therapy

NLRP2 — NLR Family Pyrin Domain Containing 2

NLRP3 Inflammasome Inhibitors for Neurodegenerative Diseases

NLRP3 Inhibitors for Neurodegeneration

NLRP3 Inflammasome Pathway in Alzheimer's Disease

NLRC3 — NLR Family CARD Domain Containing 3

NLRP3 Inflammasome Modulation for Parkinson's Disease

NLRP6 Protein (NACHT, LRR and PYD Domains-Containing Protein 6)

NLRP3 Inflammasome-Activated Microglia

NLRP7 Protein — NLR Family Pyrin Domain Containing 7

Innate Immune Reprogramming: NLRP3 + CD47 Checkpoint Blockade

NLRP3 Inflammasome Therapeutics Investment Landscape

NLRC4 Protein