Contents

ERN1/IRE1 Protein — ER Stress Sensor

🔬 Protein Info

Gene Symbol	ERN1PROTEIN
Chromosome	6p21.1.
Function	is a critical transmembrane protein that functions as a primary sensor of endoplasmic reticulum (ER) stress.
GeneCards	ERN1PROTEIN
Human Protein Atlas	ERN1PROTEIN
Kinase Domain	Catalyzes autophosphorylation upon activation
RNase Domain	Cleaves XBP1 mRNA to produce the spliced form (XBP1s)
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	rapamycin
Interactions	ABCD3, ACETYL-COA, Actin, AKT, AKT1, AKT1S1
KG Connections	981 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

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