ERS
Entity Detail — Knowledge Graph Node
Understanding Entity Pages
This page aggregates everything SciDEX knows about ERS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
AI-generated illustration · click image to enlarge
Regenerate portrait ↻Wiki Pages (8)
Knowledge base pages for this entity
CERS2 Protein (Ceramide Synthase 2)
protein · 2431 wordsCERS6 Protein
protein · 2112 wordsCERS1 — Ceramide Synthase 1
gene · 1882 wordsMARKERS-NDD Progression Markers (NCT06596746)
clinical · 1863 wordsCERS2 — Ceramide Synthase 2 (Lass2)
gene · 1604 wordsIncoming (0)
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Targeting Hypotheses (30)
Hypotheses where this entity is a therapeutic target
Mentioning Analyses (3)
Scientific analyses that reference this entity
Methodology challenge: notebook 'Mitochondrial transfer between neurons and glia
neurodegeneration | 2026-04-28 | 3 hypotheses Top: 0.604
Methodology challenge: notebook 'Mitochondrial transfer between neurons and glia
neurodegeneration | 2026-04-27 | 3 hypotheses Top: 0.604
Methodology challenge: notebook 'Astrocyte reactivity subtypes in neurodegenerat
neurodegeneration | 2026-04-27 | 3 hypotheses Top: 0.604
Experiments (20)
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| iPSC-derived astrocyte-neuron co-culture mitochondrial transfer in PD | exploratory | Parkinson's disease | 0.900 | 0.00 | iPSC-derived dopaminergic neur | proposed | N/A |
| Anti-miR-155 LNA Oligonucleotide Shifts Microglia to Homeostatic State | in_vivo | neurodegeneration | 0.774 | 0.65 | C57BL/6J LPS model (chronic i. | proposed | $58,000 |
| Single nuclei transcriptomic and epigenomic profiling of 84 donors acr | gene_expression | Alzheimer's disease | 0.500 | 0.00 | human | extracted | N/A |
| The Seattle Alzheimer's Disease Brain Cell Atlas (SEA-AD) integrates n | neuropathology | Alzheimer's disease | 0.500 | 0.00 | human | extracted | N/A |
| In late life, NfL demonstrated the strongest association with incident | clinical | Alzheimer's disease | 0.500 | 0.00 | human | extracted | N/A |
| Complex gene expression differences were identified, ranging from glob | gene_expression | Alzheimer's disease | 0.500 | 0.00 | post_mortem_brain | extracted | N/A |
| A subset of donors with particularly severe cellular and molecular phe | clinical | Alzheimer's disease | 0.500 | 0.00 | human | extracted | N/A |
| Midlife hypertension was associated with 0.15-SD faster NfL increase a | clinical | Alzheimer's disease | 0.500 | 0.00 | human | extracted | N/A |
| A subset of donors exhibited particularly severe cellular and molecula | computational | Alzheimer's disease | 0.500 | 0.00 | human | extracted | N/A |
| Cell type-specific analysis identified early-phase loss of somatostati | gene_expression | Alzheimer's disease | 0.500 | 0.00 | human | extracted | N/A |
| Single-cell/multiomics analysis of 84 human post-mortem brains reveale | computational | Alzheimer's disease | 0.500 | 0.00 | human | extracted | N/A |
| Temporal analysis of gene expression differences across disease progre | gene_expression | Alzheimer's disease | 0.500 | 0.00 | human | extracted | N/A |
| Proposed experiment from debate on Astrocytes adopt A1 (neurotoxic) an | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | completed | $100,000 |
| Metabolic Pathway-Targeted Therapy in ALS | clinical | ALS | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Animal Model Comparison for Neurodegenerative Disease Therapeutics | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $7,100,000 |
| Astrocyte Ferritin Iron Metabolism Dysfunction in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Mechanism: Selective Vulnerability of Dopaminergic Neurons in Parkinso | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $3,000,000 |
| Selective Vulnerability of Dopaminergic Neurons — Mechanism and Protec | validation | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $160,000 |
| GLP-1 Agonist Neuroprotection Mechanism in PD | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| GLP-1 Agonist Responder Prediction Study — Precision Medicine for Neur | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $5,460,000 |
Related Papers (20)
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Complement C1q/C3-CR3 signaling pathway mediates abnormal microglial phagocytosi [PMID:38642614] | Han QQ, Shen SY, Liang LF, Chen XR, Yu J | Brain Behav Immun | 2024 | 1 |
| Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704] | Zhang T, Xu D, Trefts E, Lv M, Inuzuka H | Science | 2023 | 1 |
| Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK [PMID:31693892] | Wang Y, An H, Liu T, Qin C, Sesaki H, Gu | Cell Rep | 2019 | 1 |
| AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking Sy [PMID:30057310] | Song X, Zhu S, Chen P, Hou W, Wen Q, Liu | Curr Biol | 2018 | 1 |
| Mitochondrial dysfunction and Parkinson disease: a Parkin-AMPK alliance in neuro [PMID:26121488] | Hang L, Thundyil J, Lim KL | Ann N Y Acad Sci | 2015 | 1 |
| AMPKα1 Deficiency in Macrophages Impairs Tendon Regeneration and Tendon Stem Cel [PMID:41694579] | Zhu L, Wang Y, Shi X, Yu M, Cai X, Chen | International journal of biolo | 2026 | 0 |
| Single-cell transcriptome analysis reveals a cellular immune response in common [PMID:41692207] | Shi X, Ji G, Liu D, Zhao T, Tian S, Li S | International journal of biolo | 2026 | 0 |
| Farrerol ameliorates hepatic insulin resistance via AMPKα1/mTOR/SREBP-1 pathway: [PMID:41702183] | Li Y, Feng X, Zheng L | Tissue & cell | 2026 | 0 |
| Changes in Circulating Levels of miR-30b During Minipuberty and Puberty in Girls [PMID:40899010] | Albrechtsen HM, Saritas G, Winge SB, Mai | J Clin Endocrinol Metab | 2026 | 0 |
| Epigenetics in chronic rhinosinusitis. [PMID:41442742] | Kumar N, Brar T, Lal D | Curr Opin Otolaryngol Head Nec | 2026 | 0 |
| Extracellular vesicles in type 2 diabetes exhibit elevated miR-155 cargo and Ann [PMID:41786286] | Jackson G, Islam H, de Souza Teixeira AA | Life Sci | 2026 | 0 |
| Integrative SMR prioritizes oxidative stress-related regulatory genes for Alzhei [PMID:41844011] | Wu L, Dong YT, Mu X, Luo X, Chen ZJ | J Prev Alzheimers Dis | 2026 | 0 |
| Decoding microRNA-Protein Interaction Networks in Alzheimer's Disease: Molecular [PMID:41918207] | Mishra R, Gupta JK | Curr Alzheimer Res | 2026 | 0 |
| Di-2-ethylhexylphthalate-induced miR155-5P promotes placental ferroptosis. [PMID:41937013] | Gu X, Sun F, Li Y, Yang S, Li Y | Int J Biol Macromol | 2026 | 0 |
| Extracellular Vesicles in Obesity: From Pathophysiological Mediators to Therapeu [PMID:41977323] | Pavlović N, Todorović P, Maglica M, Kopi | Int J Mol Sci | 2026 | 0 |
| Decoding microRNA-Protein Interaction Networks in Alzheimer's Disease: Molecular [PMID:41918207] | Mishra R, Gupta JK | Current Alzheimer research | 2026 | 0 |
| Integration proteomics analysis to identify AMPK as key target pathways of TCM f [PMID:41788172] | Chen YJ, Ning DS, Wang CC, Zhao HW, Wang | Journal of traditional and com | 2026 | 0 |
| Baicalein limits subchondral bone lesions via AMPKα/BECN1 activation in osteoart [PMID:41791307] | Zhai Y, Zhou P, Dan L, Ma M, Liu B, Zhan | International immunopharmacolo | 2026 | 0 |
| Integrative SMR prioritizes oxidative stress-related regulatory genes for Alzhei [PMID:41844011] | Wu L, Dong YT, Mu X, Luo X, Chen ZJ | The journal of prevention of A | 2026 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
Debates (3)
Multi-agent debates referencing this entity
Methodology challenge: notebook 'Astrocyte reactivity subtypes in neurodegenerat
active · Rounds: 4 · Score: 0.64 · 2026-04-28
Methodology challenge: notebook 'Mitochondrial transfer between neurons and glia
active · Rounds: 4 · Score: 0.64 · 2026-04-28
Methodology challenge: notebook 'Mitochondrial transfer between neurons and glia
active · Rounds: 4 · Score: 0.64 · 2026-04-28
Related Research
Hypotheses and analyses mentioning ERS in their description or question text
TREM2-Deficient Microglia as Drivers of Amyloid Plaque Toxicity in Alzheimer's D
Score: 0.827 · neurodegeneration · 2026-04-26
TREM2 loss-of-function variants impair microglial survival, clustering around amyloid plaques, and phagocytic clearance,
AMPK hypersensitivity in astrocytes creates enhanced mitochondrial rescue respon
Score: 0.822 · neurodegeneration · 2026-04-02
## Mechanistic Overview AMPK hypersensitivity in astrocytes creates enhanced mitochondrial rescue responses starts from
NLRP3 Inhibition (H7): Downstream Inflammatory Reversal
Score: 0.780 · neurodegeneration · 2026-04-25
Pharmacological NLRP3 inhibition via MCC950 breaks the lipid-inflammasome feedback loop that perpetuates microglial acti
Repeat-domain exposure defines seed-competent tau conformers
Score: 0.760 · neurodegeneration · 2026-04-26
Tau assemblies become seed-competent when their repeat-domain surfaces adopt a conformation that both survives transfer
APOE4 astrocytes exhibit impaired cholesterol efflux via ABCA1/ABCG1 transporter
Score: 0.758 · neuroscience · 2026-04-22
## Mechanistic Overview APOE4 astrocytes exhibit impaired cholesterol efflux via ABCA1/ABCG1 transporters, driving intra
NRF2 failure lowers antioxidant reserve and permits recurrent mitochondrial ROS
Score: 0.740 · neurodegeneration · 2026-04-25
Insufficient KEAP1-NRF2-ARE signaling reduces glutathione synthesis, quinone detoxification, and peroxide buffering, lea
Seed-Proximal Asymmetric Duplex Stability Confers lncRNA-0021/miR-6361 Binding S
Score: 0.733 · molecular neurobiology · 2026-04-17
**Molecular Mechanism and Rationale** The lncRNA-0021/miR-6361 interaction represents a sophisticated regulatory mechan
Temporal order is subtype-specific rather than universal
Score: 0.730 · neurodegeneration · 2026-04-25
The most defensible synthesis is that AD contains at least two trajectory classes: an amyloid-clearance/endosomal class
C9orf72 ASO Treatment Reverses TDP-43 Pathology in ALS/FTD
Score: 0.720 · neurodegeneration · 2026-04-26
Antisense oligonucleotides targeting C9orf72 hexanucleotide repeat expansion reduce toxic DPR proteins and RNA foci, res
Metabolic Reprogramming to Reverse Senescence
Score: 0.720 · unknown disease · 2026-04-16
# Metabolic Reprogramming to Reverse Senescence in Neurodegeneration: A Mechanistic Hypothesis ## The Senescence Conund
APOE Isoform Conversion Therapy
Score: 0.718 · neurodegeneration · 2026-04-02
## Mechanistic Overview APOE Isoform Conversion Therapy starts from the claim that modulating APOE within the disease co
Closed-loop focused ultrasound targeting CA1 PV interneurons to restore theta-ga
Score: 0.716 · Alzheimer's disease · 2026-04-07
## Mechanistic Overview Closed-loop focused ultrasound targeting CA1 PV interneurons to restore theta-gamma coupling and