gene

IFNG

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IFNG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

538Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

IFNG is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, expressed in. Associated with ALS, Als, Atherosclerosis. Connected to 219 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	IFNG
Protein Type	Gene
Function	IFN-γ is a homodimeric type II interferon that signals through the IFNGR1/IFNGR2 receptor complex.
Pathways	Akt, Wnt
GeneCards	IFNG
Human Protein Atlas	IFNG
Associated Diseases	Als, Alzheimer, Alzheimer's disease, Autoimmune, periodontitis
Known Drugs/Compounds	rapamycin, RAPAMYCIN
Interactions	Actin, AKT1, AKT1S1, AMBRA1, AMPK, AND
SciDEX Hypotheses	Optimized Temporal Window for Metabolic Boosting T
KG Connections	538 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

IFNG Gene

gene · 720 words

→

Pathway Diagram

flowchart TD
    CD4_T_CELLS["CD4+ T Cells"]
    IFNG["IFNG
(Interferon Gamma)"]
    
    AUTOPHAGY_REG["Autophagy
Regulation"]
    LC3["LC3"]
    BECN1["BECN1
(Beclin-1)"]
    MAP1LC3A["MAP1LC3A"]
    NBR1["NBR1"]
    
    MTOR_PATH["mTOR
Pathway"]
    RPTOR["RPTOR
(Raptor)"]
    DEPTOR["DEPTOR"]
    
    ER_STRESS["ER Stress
Response"]
    EIF2AK3["EIF2AK3
(PERK)"]
    ATF6["ATF6"]
    DDIT3["DDIT3
(CHOP)"]
    HSP70["HSP70"]
    
    CELL_DEATH["Cell Death
Pathways"]
    RIPK1["RIPK1"]
    MLKL["MLKL"]
    
    NEURO_DISEASES["Neurodegeneration"]
    ALS["ALS"]
    MS["Multiple
Sclerosis"]
    
    CD4_T_CELLS -->|"produces"| IFNG
    
    IFNG -->|"regulates"| AUTOPHAGY_REG
    AUTOPHAGY_REG --> LC3
    AUTOPHAGY_REG --> BECN1
    AUTOPHAGY_REG --> MAP1LC3A
    AUTOPHAGY_REG --> NBR1
    
    IFNG -->|"modulates"| MTOR_PATH
    MTOR_PATH --> RPTOR
    MTOR_PATH --> DEPTOR
    
    IFNG -->|"triggers"| ER_STRESS
    ER_STRESS --> EIF2AK3
    ER_STRESS --> ATF6
    ER_STRESS --> DDIT3
    ER_STRESS --> HSP70
    
    IFNG -->|"activates"| CELL_DEATH
    CELL_DEATH --> RIPK1
    CELL_DEATH --> MLKL
    
    IFNG -->|"regulates"| ALS
    IFNG -->|"interacts_with"| MS
    ALS --> NEURO_DISEASES
    MS --> NEURO_DISEASES
    
    style IFNG fill:#006494
    style HSP70 fill:#1b5e20
    style BECN1 fill:#1b5e20
    style AUTOPHAGY_REG fill:#4a1a6b
    style MTOR_PATH fill:#4a1a6b
    style ER_STRESS fill:#ef5350
    style CELL_DEATH fill:#ef5350
    style NEURO_DISEASES fill:#5d4400
    style ALS fill:#5d4400
    style MS fill:#5d4400

Outgoing (324)

Target	Relation	Type	Str
ISG	upregulates	pathway	0.95
osteoblastogenesis	activates	pathway	0.90
CD274	upregulates	gene	0.90
Inflammation	associated_with	process	0.90
CXCL10	upregulates	protein	0.90
CXCL11	upregulates	protein	0.90
Myeloid Cell Immune Response	involved_in	process	0.90
CXCL9	upregulates	protein	0.90
Myeloid Cell Immune Response	mediates	process	0.85
Staphylococcus Aureus Infection	involved_in	disease	0.85
Brain Inflammation	involved_in	process	0.85
ILC1	drives	cell_type	0.85
metabolic inflammation	drives	process	0.85
Staphylococcus Aureus Infection	mediates	disease	0.85
T cell exhaustion	promotes	process	0.80
innate immune response	promotes	process	0.80
GENES	associated_with	gene	0.80
Als	associated_with	disease	0.75
Als	expressed_in	disease	0.65
Atherosclerosis	expressed_in	disease	0.65
Inflammation	expressed_in	disease	0.65
Fibrosis	interacts_with	disease	0.65
Tumor	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	interacts_with	disease	0.65
MLKL	activates	gene	0.65
ROS	phosphorylates	gene	0.65
Cancer	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
STING	phosphorylates	gene	0.65
ALS	expressed_in	disease	0.65
ALS	associated_with	disease	0.65
Rheumatoid Arthritis	associated_with	disease	0.65
Autoimmune	associated_with	disease	0.65
Cancer	activates	disease	0.65
ALS	interacts_with	disease	0.65
Tumor	activates	disease	0.65
Als	regulates	disease	0.65
Fibrosis	regulates	disease	0.65
T CELL	regulates	cell_type	0.65
MAPK14	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
ATF6	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
HSP70	interacts_with	gene	0.60
TFE3	interacts_with	gene	0.60
MAP1LC3A	interacts_with	gene	0.60
MLKL	interacts_with	gene	0.60
DEPTOR	interacts_with	gene	0.60

Incoming (214)

Source	Relation	Type	Str
Tralokinumab	downregulates	drug	0.90
NM1	inhibits	protein	0.85
T cell exhaustion	upregulates	phenotype	0.80
HMGB1	associated_with	gene	0.65
DENDRITIC CELL	interacts_with	cell_type	0.65
CD4_T_CELLS	produces	cell_type	0.64
GCN2	interacts_with	gene	0.60
SLEEP-WAKE CYCLE	activates	gene	0.60
AND	activates	gene	0.60
HUB GENES	associated_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
AND	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
RNA	activates	gene	0.60
IFN	associated_with	gene	0.60
CLDN1	expressed_in	gene	0.60
CANCER	activates	gene	0.60
CANCER	phosphorylates	entity	0.60
EGF	activates	gene	0.60
EGFR	targets	gene	0.60
GSK3B	targets	gene	0.60
HIF1A	targets	gene	0.60
GFAP	biomarker_for	gene	0.60
CCL26	expressed_in	gene	0.60
GENES	activates	gene	0.60
ATG	interacts_with	gene	0.60
CYP1A1	activates	gene	0.60
DNA	activates	gene	0.60
GCN2	activates	gene	0.60
IFN	activates	gene	0.60
rapamycin	targets	drug	0.60
RICTOR	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
MAP1LC3A	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
MAVS	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
APC	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
RIPK1	interacts_with	gene	0.60
MAPK14	interacts_with	gene	0.60
MLKL	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
ATF6	interacts_with	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
HSPA5	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Optimized Temporal Window for Metabolic Boosting Therapy Det	0.879	neurodegeneration	How do different microglial subtypes (DA

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do different microglial subtypes (DAM vs inflammatory vs homeostatic) transi

neurodegeneration | 2026-04-16 | 5 hypotheses Top: 0.919

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Multiple Sclerosis Pathology. [PMID:29358320]	Lassmann H	Cold Spring Harbor perspective	2018

Debates (1)

Multi-agent debates referencing this entity

The debate framework mentioned multiple microglial subtypes but no analysis was

unknown · Rounds: 4 · Score: 1.00 · 2026-04-18

Related Research

Hypotheses and analyses mentioning IFNG in their description or question text

No additional research found