concept

ACETYL-COA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ACETYL-COA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

584Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ACETYL-COA is a concept in neurodegeneration research. Key relationships include: activates, associated with, inhibits. Associated with ALS, Aging, Als. Connected to 391 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ACETYL-COA
Key Genes/Proteins	ACAT1, ACC, ACHE, ACLY, Actin, AGING
Related Diseases	Aging, Als, ALS, Alzheimer
Related Pathways	Akt, Alpha-Synuclein

Pathway Diagram

graph TD
    ACETYL_COA["ACETYL-COA"]
    ACETYL_COA -->|"activates"| STAT3["STAT3"]
    ACETYL_COA -->|"activates"| histone_acetylation["histone acetylation"]
    ACETYL_COA -->|"activates"| Tumor["Tumor"]
    ACETYL_COA -->|"activates"| Ms["Ms"]
    ACETYL_COA -->|"activates"| Als["Als"]
    ACETYL_COA -->|"inhibits"| Cardiovascular["Cardiovascular"]
    ACETYL_COA -->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    ACETYL_COA -->|"interacts"| Alzheimer["Alzheimer"]
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| ACETYL_COA
    AMPK["AMPK"] -->|"activates"| ACETYL_COA
    BNIP3["BNIP3"] -->|"activates"| ACETYL_COA
    BCL2["BCL2"] -->|"activates"| ACETYL_COA
    GLI1["GLI1"] -->|"activates"| ACETYL_COA
    ATG["ATG"] -->|"activates"| ACETYL_COA
    BECN1["BECN1"] -->|"activates"| ACETYL_COA
    ATG7["ATG7"] -->|"activates"| ACETYL_COA
    PIK3C3["PIK3C3"] -->|"activates"| ACETYL_COA
    MITOPHAGY["MITOPHAGY"] -->|"activates"| ACETYL_COA

Outgoing (365)

Target	Relation	Type	Str
Cancer	inhibits	disease	0.95
Cancer	activates	disease	0.95
EP300	activates	protein	0.90
STAT3	activates	gene	0.90
P300	activates	protein	0.85
Als	activates	disease	0.85
STAT3	activates	protein	0.85
Tumor	inhibits	disease	0.85
Tumor	activates	disease	0.85
Obesity	activates	disease	0.85
Inflammation	activates	disease	0.85
histone acetylation	activates	phenotype	0.80
Autophagy	activates	pathway	0.80
AUTOPHAGY	activates	gene	0.80
MICROGLIA	activates	gene	0.80
CANCER	activates	gene	0.80
ATP	activates	gene	0.80
Als	regulates	disease	0.75
Tumor	therapeutic_target	disease	0.75
Als	therapeutic_target	disease	0.75
microglial_activation	modulates	mechanism	0.75
Lung Cancer	inhibits	disease	0.75
Lipid Metabolism	associated_with	pathway	0.70
Glycolysis	activates	pathway	0.70
STAT3	activates	protein	0.70
Epigenetic	regulates	pathway	0.70
Angiogenesis	inhibits	pathway	0.70
AUTOPHAGY	regulates	gene	0.70
Mitophagy	activates	pathway	0.70
CANCER	inhibits	gene	0.70
AMPK	activates	gene	0.70
Autophagy	regulates	pathway	0.70
STAT3	regulates	protein	0.70
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.70
MITOCHONDRIA	activates	gene	0.70
Oxidative Phosphorylation	activates	pathway	0.70
GENES	activates	gene	0.70
Mtor	inhibits	pathway	0.70
Invasion	inhibits	pathway	0.70
Neurodegeneration	protects_against	disease	0.65
Neuroinflammation	protects_against	disease	0.65
Alzheimer	protects_against	disease	0.65
Ischemia	protects_against	disease	0.65
Cancer	regulates	disease	0.65
Parkinson	protects_against	disease	0.65
Pancreatic Cancer	activates	disease	0.65
Prostate Cancer	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Aging	inhibits	disease	0.65
Anxiety	causes	disease	0.65

Incoming (219)

Source	Relation	Type	Str
CANCER	inhibits	gene	0.70
MITOPHAGY	activates	gene	0.70
SIRT1	activates	gene	0.70
AKT	regulates	gene	0.60
SNCA	activates	gene	0.60
RAPTOR	activates	gene	0.60
ALPHA-SYNUCLEIN	activates	gene	0.60
PTEN	activates	gene	0.60
ARID1A	contributes_to	gene	0.60
INFLAMMATION	activates	gene	0.60
PERK	activates	gene	0.60
DNA	activates	gene	0.60
LKB1	activates	gene	0.60
ACLY	activates	gene	0.60
HEDGEHOG	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
FAS	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
EIF4EBP1	regulates	gene	0.60
AUTOPHAGY	activates	gene	0.60
AMPK	regulates	gene	0.60
AMPK	activates	gene	0.60
INFLAMMATION	contributes_to	gene	0.60
ACAT1	associated_with	gene	0.60
KAT8	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
NDP52	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
PIK3C3	associated_with	gene	0.60
CREB	associated_with	gene	0.60
WIPI2	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
SLC7A11	inhibits	gene	0.60
NCOA4	inhibits	gene	0.60
KRAS	inhibits	gene	0.60
ACC	therapeutic_target	gene	0.60
ACAT1	interacts_with	gene	0.60
MITOPHAGY	inhibits	gene	0.60
DNA	inhibits	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
STX17	associated_with	gene	0.60
APOPTOSIS	inhibits	gene	0.60
STAT3	activates	gene	0.60
CANCER	expressed_in	gene	0.60
ATM	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ACETYL-COA in their description or question text

No additional research found