concept

ACTIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ACTIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1568Connections

3Hypotheses

0Analyses

50Outgoing

50Incoming

1Experiments

0Debates

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💡 Concept Info

Name	ACTIN
Key Genes/Proteins	4E-BP1, ABCA1, ABCD3, ABCG1, ACTB, ALZHEIMER DISEASE
Related Diseases	ALS, ATHEROSCLEROSIS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Actin Cytoskeleton Dynamics in Neurodegeneration

mechanism · 3067 words

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Pathway Diagram

graph TD
    ACTIN["ACTIN"]
    style ACTIN fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    ACTIN -->|"interacts"| Dementia["Dementia"]
    ACTIN -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    ACTIN -->|"interacts"| Als["Als"]
    ACTIN -.->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    ACTIN -->|"interacts"| Alzheimer["Alzheimer"]
    ACTIN -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    ACTIN -->|"interacts"| Parkinson["Parkinson"]
    ACTIN -.->|"protects against"| Neurodegeneration["Neurodegeneration"]
    PIEZO1([PIEZO1]) -->|"regulates"| ACTIN
    FUS([FUS]) -->|"interacts"| ACTIN
    TAX1BP1([TAX1BP1]) -->|"interacts"| ACTIN
    ALS([ALS]) -->|"interacts"| ACTIN
    TOLLIP([TOLLIP]) -->|"interacts"| ACTIN
    G3BP1([G3BP1]) -->|"interacts"| ACTIN
    ULK1([ULK1]) -->|"interacts"| ACTIN
    DEMENTIA([DEMENTIA]) -->|"interacts"| ACTIN
    GFP([GFP]) -->|"interacts"| ACTIN
    CALCOCO2([CALCOCO2]) -->|"interacts"| ACTIN

Outgoing (437)

Target	Relation	Type	Str
macrophage activation	drives	process	0.80
microtubule	interacts_with	protein	0.75
Parkinson	activates	disease	0.60
Neuroinflammation	activates	disease	0.60
Diabetes	regulates	disease	0.60
Als	associated_with	disease	0.60
Als	protects_against	disease	0.60
Aging	biomarker_for	disease	0.60
Alzheimer	protects_against	disease	0.60
Encephalitis	interacts_with	disease	0.60
Cardiomyopathy	regulates	disease	0.60
Als	transports	disease	0.60
Als	activates	disease	0.60
Necroptosis	therapeutic_target	disease	0.60
Frontotemporal Dementia	therapeutic_target	disease	0.60
Neurodegeneration	regulates	disease	0.60
Dementia	activates	disease	0.60
Fibrosis	inhibits	disease	0.60
Neurodegeneration	protects_against	disease	0.60
Necroptosis	interacts_with	disease	0.60
Neurodegeneration	contributes_to	disease	0.60
Tauopathy	stabilizes	disease	0.60
Neuropathy	regulates	disease	0.60
Parkinson	protects_against	disease	0.60
Ischemia	regulates	disease	0.60
Als	expressed_in	disease	0.60
Cancer	activates	disease	0.60
Aging	degrades	disease	0.60
Ischemia	associated_with	disease	0.60
Frontotemporal Dementia	activates	disease	0.60
Senescence	inhibits	disease	0.60
Depression	inhibits	disease	0.60
Tauopathy	activates	disease	0.60
Encephalitis	therapeutic_target	disease	0.60
Fibrosis	activates	disease	0.60
Als	causes	disease	0.60
Cancer	therapeutic_target	disease	0.60
Neurodegeneration	biomarker_for	disease	0.60
Neuroinflammation	biomarker_for	disease	0.60
Neurodegeneration	activates	disease	0.60
Aging	regulates	disease	0.60
Ischemia	activates	disease	0.60
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.60
Parkinson	therapeutic_target	disease	0.60
Huntington	therapeutic_target	disease	0.60
Ischemia	therapeutic_target	disease	0.60
Alzheimer	causes	disease	0.60
Alzheimer	stabilizes	disease	0.60
Aging	interacts_with	disease	0.60
Frontotemporal Dementia	interacts_with	disease	0.60

Incoming (1131)

Source	Relation	Type	Str
PIEZO1	interacts_with	gene	0.85
Piezo1	positively_regulates	gene	0.70
PIEZO1	regulates	protein	0.64
ALS	inhibits	gene	0.60
RUBCNL	interacts_with	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
CYTOKINES	regulates	gene	0.60
DEPRESSION	therapeutic_target	gene	0.60
APOPTOSIS	inhibits	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
ROS	inhibits	gene	0.60
SQSTM1	inhibits	gene	0.60
HSPB1	activates	gene	0.60
STROKE	activates	gene	0.60
PHAGOCYTOSIS	therapeutic_target	gene	0.60
VPS4A	inhibits	gene	0.60
ANXIETY	therapeutic_target	gene	0.60
TRIM11	regulates	gene	0.60
TAU	activates	gene	0.60
CD38	activates	gene	0.60
NAD	activates	gene	0.60
CYTOKINES	causes	gene	0.60
TRPV4	causes	gene	0.60
NEURON	causes	gene	0.60
GAIN	causes	gene	0.60
IL-17	activates	gene	0.60
AMYLOID	activates	gene	0.60
APOE4	associated_with	gene	0.60
MICRORNAS	associated_with	gene	0.60
RNA	expressed_in	gene	0.60
CD8	expressed_in	gene	0.60
HUNTINGTON	therapeutic_target	gene	0.60
FLCN	interacts_with	gene	0.60
STING	activates	gene	0.60
MTORC1	interacts_with	gene	0.60
MITF	activates	gene	0.60
TFE3	activates	gene	0.60
LYSOSOME	activates	gene	0.60
GABA	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
CGAS-STING	activates	gene	0.60
CGAS	activates	gene	0.60
GABARAP	interacts_with	gene	0.60
RETREG1	interacts_with	gene	0.60
WIPI2	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
RIPK1	regulates	gene	0.60
RUBCNL	regulates	gene	0.60
GAIN	regulates	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TREM2-ABI3 actin-phagocytosis coupling is a higher-yield AD	0.620	alzheimers	-
Microglial priming is primarily epigenetic, with metabolic c	0.609	neuroinflammation	Do microglia actually switch between gly
Structure-interacting small molecules that stabilize the APO	0.580	neuroscience	APOE4-driven lipid metabolism dysregulat

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Longitudinal dietary change analysis and ADRD risk over 10 years	clinical	Alzheimer's disease and relate	0.930	0.00	human patients	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ACTIN in their description or question text

No additional research found