concept

ACTIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ACTIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1568Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

1Experiments

0Debates

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💡 Concept Info

Name	ACTIN
Key Genes/Proteins	4E-BP1, ABCA1, ABCD3, ABCG1, ACTB, ALZHEIMER DISEASE
Related Diseases	ALS, ATHEROSCLEROSIS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Actin Cytoskeleton Dynamics in Neurodegeneration

mechanism · 3067 words

→

Pathway Diagram

graph TD
    ACTIN["ACTIN"]
    style ACTIN fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    ACTIN -->|"interacts"| Dementia["Dementia"]
    ACTIN -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    ACTIN -->|"interacts"| Als["Als"]
    ACTIN -.->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    ACTIN -->|"interacts"| Alzheimer["Alzheimer"]
    ACTIN -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    ACTIN -->|"interacts"| Parkinson["Parkinson"]
    ACTIN -.->|"protects against"| Neurodegeneration["Neurodegeneration"]
    PIEZO1([PIEZO1]) -->|"regulates"| ACTIN
    FUS([FUS]) -->|"interacts"| ACTIN
    TAX1BP1([TAX1BP1]) -->|"interacts"| ACTIN
    ALS([ALS]) -->|"interacts"| ACTIN
    TOLLIP([TOLLIP]) -->|"interacts"| ACTIN
    G3BP1([G3BP1]) -->|"interacts"| ACTIN
    ULK1([ULK1]) -->|"interacts"| ACTIN
    DEMENTIA([DEMENTIA]) -->|"interacts"| ACTIN
    GFP([GFP]) -->|"interacts"| ACTIN
    CALCOCO2([CALCOCO2]) -->|"interacts"| ACTIN

Outgoing (437)

Target	Relation	Type	Str
macrophage activation	drives	process	0.80
microtubule	interacts_with	protein	0.75
Bipolar	therapeutic_target	disease	0.60
Aging	inhibits	disease	0.60
Amyotrophic Lateral Sclerosis	regulates	disease	0.60
Stroke	activates	disease	0.60
Depression	activates	disease	0.60
Cancer	interacts_with	disease	0.60
Epilepsy	activates	disease	0.60
Necroptosis	activates	disease	0.60
Cancer	inhibits	disease	0.60
Aging	activates	disease	0.60
Necroptosis	regulates	disease	0.60
Cancer	expressed_in	disease	0.60
Als	causes	disease	0.60
Atherosclerosis	inhibits	disease	0.60
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.60
Dementia	activates	disease	0.60
Als	interacts_with	disease	0.60
Als	activates	disease	0.60
Alzheimer	interacts_with	disease	0.60
Huntington	activates	disease	0.60
Parkinson	inhibits	disease	0.60
Als	inhibits	disease	0.60
Parkinson	interacts_with	disease	0.60
Als	transports	disease	0.60
Ischemia	regulates	disease	0.60
Fibrosis	regulates	disease	0.60
Fibrosis	activates	disease	0.60
Leukemia	activates	disease	0.60
Schizophrenia	activates	disease	0.60
Alzheimer	activates	disease	0.60
Cancer	therapeutic_target	disease	0.60
Neurodegeneration	activates	disease	0.60
Ischemia	activates	disease	0.60
Frontotemporal Dementia	activates	disease	0.60
Tauopathy	stabilizes	disease	0.60
Alzheimer	stabilizes	disease	0.60
Parkinson	activates	disease	0.60
Neurodegeneration	protects_against	disease	0.60
Frontotemporal Dementia	associated_with	disease	0.60
Dementia	associated_with	disease	0.60
Amyotrophic Lateral Sclerosis	associated_with	disease	0.60
Als	expressed_in	disease	0.60
Cancer	activates	disease	0.60
Aging	degrades	disease	0.60
Ischemia	associated_with	disease	0.60
Frontotemporal Dementia	interacts_with	disease	0.60
Dementia	interacts_with	disease	0.60
Migraine	activates	disease	0.60

Incoming (1131)

Source	Relation	Type	Str
PIEZO1	interacts_with	gene	0.85
Piezo1	positively_regulates	gene	0.70
PIEZO1	regulates	protein	0.64
CCND1	associated_with	gene	0.60
GPNMB	activates	gene	0.60
FAM83A	associated_with	gene	0.60
GSK3B	associated_with	gene	0.60
AXIN	associated_with	gene	0.60
RAB35	stabilizes	gene	0.60
AXIN2	associated_with	gene	0.60
RAB7A	associated_with	gene	0.60
TSPAN1	associated_with	gene	0.60
TCF4	associated_with	gene	0.60
ALZHEIMER	stabilizes	gene	0.60
RAB7A	stabilizes	gene	0.60
TAU	stabilizes	gene	0.60
RAS	associated_with	gene	0.60
LYSOSOME	stabilizes	gene	0.60
ENDOSOME	stabilizes	gene	0.60
TAUOPATHY	stabilizes	gene	0.60
CHMP6	stabilizes	gene	0.60
TSG101	stabilizes	gene	0.60
DRD2	activates	gene	0.60
SLC6A2	activates	gene	0.60
SLC6A3	activates	gene	0.60
SNCA	activates	gene	0.60
SLC6A4	activates	gene	0.60
ABCB1	activates	gene	0.60
NUCKS1	activates	gene	0.60
CYP2D6	activates	gene	0.60
PARKINSON	activates	gene	0.60
LRRK2	activates	gene	0.60
LAMP1	associated_with	gene	0.60
GCH1	activates	gene	0.60
SIRT1	regulates	gene	0.60
NAMPT	regulates	gene	0.60
NAD	associated_with	gene	0.60
AGING	associated_with	gene	0.60
LIF	activates	gene	0.60
HEDGEHOG	activates	gene	0.60
HIPPO	activates	gene	0.60
EGFR	activates	gene	0.60
CYTOKINES	activates	gene	0.60
IL-6	expressed_in	gene	0.60
OCLN	interacts_with	gene	0.60
POSTN	activates	gene	0.60
PIEZO1	expressed_in	gene	0.60
CRH	interacts_with	gene	0.60
CRH	activates	gene	0.60
APOPTOSIS	activates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Microglial priming is primarily epigenetic, with metabolic c	0.609	neuroinflammation	Do microglia actually switch between gly
Structure-interacting small molecules that stabilize the APO	0.580	neuroscience	APOE4-driven lipid metabolism dysregulat

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Longitudinal dietary change analysis and ADRD risk over 10 years	clinical	Alzheimer's disease and relate	0.930	0.00	human patients	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ACTIN in their description or question text

No additional research found