Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about AKT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
A protein referenced in 1 knowledge graph relationship. Key connections: PI3K (protein) activates.
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| Gene Symbol | AKT |
| Pathways | AUTOPHAGY, EV-A71 Infection, Inflammatory Cytokine Secretion, LIPID METABOLISM, Methamphetamine Toxicity |
| GeneCards | AKT |
| Human Protein Atlas | AKT |
| Associated Diseases | AD, ADH, Aging, ALI, Als |
| Known Drugs/Compounds | AKT Inhibitors, Andrographis paniculata, ANTHOCYANINS, Arsenic trioxide, capivasertib, Capivasertib |
| Interactions | 6-OHDA, ABCA1, ABCB1, ABCG1, ABCG2, ACAT1 |
| KG Connections | 5659 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
AKT["AKT"] -->|"activates"| MTOR["MTOR"]
AKT["AKT"] -.->|"inhibits"| Als["Als"]
AKT["AKT"] -.->|"inhibits"| Autophagy["Autophagy"]
AKT["AKT"] -.->|"inhibits"| Mtor["Mtor"]
AKT["AKT"] -->|"activates"| Als_1["Als"]
AKT["AKT"] -->|"activates"| Angiogenesis["Angiogenesis"]
AKT["AKT"] -->|"activates"| MYC["MYC"]
AKT["AKT"] -->|"activates"| Cancer["Cancer"]
AKT["AKT"] -->|"activates"| Tumor["Tumor"]
NRF2["NRF2"] -->|"activates"| AKT["AKT"]
PTEN["PTEN"] -.->|"inhibits"| AKT["AKT"]
EGFR["EGFR"] -->|"activates"| AKT["AKT"]
PI3K["PI3K"] -->|"activates"| AKT["AKT"]
PI3K_2["PI3K"] -.->|"inhibits"| AKT["AKT"]
PTEN_3["PTEN"] -->|"activates"| AKT["AKT"]
style AKT fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
style MTOR fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Als fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Autophagy fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Mtor fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Als_1 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Angiogenesis fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style MYC fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Cancer fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Tumor fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style NRF2 fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style PTEN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style EGFR fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style PI3K fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style PI3K_2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style PTEN_3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Autophagy | inhibits | pathway | 1.00 |
| Mtor | regulates | pathway | 1.00 |
| MULTIPLE SCLEROSIS | associated_with | disease | 1.00 |
| Mtor | therapeutic_target | pathway | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | disease | 1.00 |
| Mtor | activates | pathway | 1.00 |
| Differentiation | activates | pathway | 1.00 |
| NF-KB | associated_with | protein | 1.00 |
| Breast Cancer | treats | disease | 1.00 |
| Stem Cell | activates | pathway | 1.00 |
| Immunotherapy | therapeutic_target | pathway | 1.00 |
| Hepatocellular Carcinoma | activates | disease | 1.00 |
| Mtor | inhibits | pathway | 1.00 |
| Stem Cell | therapeutic_target | pathway | 1.00 |
| Melanoma | therapeutic_target | disease | 1.00 |
| Colorectal Cancer | activates | disease | 1.00 |
| MITOCHONDRIA | activates | gene | 1.00 |
| Epithelial-Mesenchymal Transition | regulates | pathway | 1.00 |
| Receptor Tyrosine Kinase | activates | pathway | 1.00 |
| Metastasis | activates | pathway | 1.00 |
| Tumor Microenvironment | therapeutic_target | pathway | 1.00 |
| Inflammation | treats | disease | 1.00 |
| Cancer | treats | disease | 1.00 |
| Differentiation | regulates | pathway | 1.00 |
| proteins-akt | has_wiki | wiki_page | 1.00 |
| Ferroptosis | therapeutic_target | pathway | 1.00 |
| PARKINSON'S DISEASE | associated_with | disease | 1.00 |
| Infection | activates | disease | 1.00 |
| Breast Cancer | therapeutic_target | disease | 1.00 |
| Microrna | regulates | pathway | 1.00 |
| Drug Resistance | therapeutic_target | pathway | 1.00 |
| Epithelial-Mesenchymal Transition | activates | pathway | 1.00 |
| Drug Resistance | activates | pathway | 1.00 |
| Pi3K/Akt | therapeutic_target | pathway | 1.00 |
| AGING | activates | gene | 1.00 |
| Pi3K/Akt | regulates | pathway | 1.00 |
| Cell Cycle | inhibits | pathway | 1.00 |
| Pi3K/Akt | inhibits | pathway | 1.00 |
| Als | treats | disease | 1.00 |
| Invasion | therapeutic_target | pathway | 1.00 |
| Metastasis | regulates | pathway | 1.00 |
| Invasion | activates | pathway | 1.00 |
| Differentiation | therapeutic_target | pathway | 1.00 |
| DNA | activates | gene | 1.00 |
| Metastasis | therapeutic_target | pathway | 1.00 |
| Pi3K/Akt | activates | pathway | 1.00 |
| Sepsis | activates | disease | 1.00 |
| Breast Cancer | activates | disease | 1.00 |
| Lung Cancer | therapeutic_target | disease | 1.00 |
| Autophagy | regulates | pathway | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| OXIDATIVE STRESS | activates | gene | 1.00 |
| PI3K | associated_with | gene | 1.00 |
| GENES | inhibits | gene | 1.00 |
| capivasertib | inhibits | drug | 1.00 |
| GENES | expressed_in | gene | 1.00 |
| EGFR | activates | protein | 1.00 |
| PTEN | inhibits | gene | 1.00 |
| PI3K | therapeutic_target | gene | 1.00 |
| TNF-Α | activates | gene | 1.00 |
| CANCER | treats | gene | 1.00 |
| NEURODEGENERATION | therapeutic_target | gene | 1.00 |
| STROKE | activates | gene | 1.00 |
| NF-ΚB | regulates | gene | 1.00 |
| HIF | activates | gene | 1.00 |
| CREB | activates | gene | 1.00 |
| GENES | regulates | gene | 1.00 |
| proteins-akt | described_by | wiki_page | 1.00 |
| PTEN | regulates | gene | 1.00 |
| ALZHEIMER'S DISEASE | therapeutic_target | gene | 1.00 |
| STAT3 | therapeutic_target | gene | 1.00 |
| PTEN | therapeutic_target | gene | 1.00 |
| OXIDATIVE STRESS | inhibits | gene | 1.00 |
| CYTOKINES | therapeutic_target | gene | 1.00 |
| AUTOPHAGY | therapeutic_target | gene | 1.00 |
| ROS | activates | gene | 1.00 |
| ALZHEIMER | activates | gene | 1.00 |
| MTORC1 | activates | gene | 1.00 |
| BDNF | activates | gene | 1.00 |
| TNF | inhibits | gene | 1.00 |
| EGFR | therapeutic_target | gene | 1.00 |
| JNK | activates | gene | 1.00 |
| PDPK1 | activates | gene | 1.00 |
| ERK | therapeutic_target | gene | 1.00 |
| RAS | activates | gene | 1.00 |
| P53 | activates | gene | 1.00 |
| PI3K | regulates | gene | 1.00 |
| BAX | activates | gene | 1.00 |
| IL-6 | activates | gene | 1.00 |
| NF-ΚB | activates | gene | 1.00 |
| TP53 | therapeutic_target | gene | 1.00 |
| ROS | regulates | gene | 1.00 |
| PTEN | activates | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| PI3K | inhibits | gene | 1.00 |
| AUTOPHAGY | regulates | gene | 1.00 |
| TNF | therapeutic_target | gene | 1.00 |
| OXIDATIVE STRESS | therapeutic_target | gene | 1.00 |
| AMPK | activates | gene | 1.00 |
| ERK | inhibits | gene | 1.00 |
| INFLAMMATION | inhibits | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TREM2-DAP12 Signalosome Enhancement — Boosting PI3K-AKT-mTOR | 0.718 | Alzheimer's disease | TREM2 agonism vs antagonism in DAM micro |
| CD44-Mediated Src/PI3K/Akt Signaling Cascade | 0.470 | neuroinflammation | What molecular mechanisms mediate SPP1-i |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.710
neurodegeneration | 2026-04-04 | 15 hypotheses Top: 0.814
neurodegeneration | 2026-04-03 | 45 hypotheses Top: 0.990
neurodegeneration | 2026-04-02 | 5 hypotheses Top: 0.761
neurodegeneration | 2026-04-02 | 7 hypotheses Top: 0.741
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Single-cell RNA sequencing of microglial states in AD hippocampus | exploratory | Alzheimer's disease | 0.850 | 0.00 | AD mouse hippocampus | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.90 · 2026-04-12
closed · Rounds: 4 · Score: 0.69 · 2026-04-12
closed · Rounds: 4 · Score: 0.80 · 2026-04-12
closed · Rounds: 5 · Score: 0.93 · 2026-04-11
closed · Rounds: 7 · Score: 0.91 · 2026-04-10
closed · Rounds: 4 · Score: 0.91 · 2026-04-06
closed · Rounds: 4 · Score: 0.90 · 2026-04-06
closed · Rounds: 4 · Score: 0.87 · 2026-04-06
closed · Rounds: 4 · Score: 0.93 · 2026-04-06
closed · Rounds: 3 · Score: 0.95 · 2026-04-04
Hypotheses and analyses mentioning AKT in their description or question text
No additional research found