Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PI3K: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
A protein referenced in 2 knowledge graph relationships. Key connections: activates AKT (protein); SYK_kinase (protein) activates.
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| Gene Symbol | PI3K |
| Full Name | Phosphoinositide 3-Kinase |
| Aliases | Phosphatidylinositol 3-kinase, VPS34 |
| Chromosome | Various (multiple genes across classes) |
| Protein Type | Kinase |
| Function | Class I PI3Ks: Generate PIP3 from PIP2 - Activated by receptor tyrosine kinases (RTKs), G-protein coupled receptors (GPCRs), and small GTPases (Ras) - p110α (PIK3CA): growth factor signaling |
| Pathways | AUTOPHAGY, LIPID METABOLISM, OXIDATIVE_STRESS, PI3K/AKT, PI3K_AKT_MTOR_pathway |
| NCBI Gene ID | 5290 |
| GeneCards | PI3K |
| Human Protein Atlas | PI3K |
| Associated Diseases | AD, aging, Als, Alzheimer |
| Known Drugs/Compounds | AFB1, alpelisib, Apitolisib, BERBERINE, CAMP, carvone |
| Interactions | 6-OHDA, ABCA1, ABCG1, ACAT1, ACHE, ACLY |
| KG Connections | 4925 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
subgraph Pathology["Pathology"]
PI3K["PI3K"] -->|"associated with"| CANCER["CANCER"]
end
subgraph Signaling["Signaling"]
PI3K["PI3K"] -->|"activates"| AKT["AKT"]
PI3K["PI3K"] -.->|"inhibits"| MTOR["MTOR"]
PI3K["PI3K"] -.->|"inhibits"| AKT_1["AKT"]
PI3K["PI3K"] -.->|"inhibits"| GENES["GENES"]
PI3K["PI3K"] -.->|"inhibits"| Als["Als"]
PI3K["PI3K"] -.->|"inhibits"| Autophagy["Autophagy"]
PI3K["PI3K"] -.->|"inhibits"| Mtor["Mtor"]
PI3K["PI3K"] -->|"activates"| Cancer["Cancer"]
PTEN["PTEN"] -.->|"inhibits"| PI3K["PI3K"]
PTEN_2["PTEN"] -->|"activates"| PI3K["PI3K"]
AKT_4["AKT"] -->|"activates"| PI3K["PI3K"]
MTOR_5["MTOR"] -->|"activates"| PI3K["PI3K"]
TNF["TNF"] -->|"activates"| PI3K["PI3K"]
end
subgraph Therapeutic["Therapeutic"]
PTEN_3["PTEN"] -->|"therapeutic target"| PI3K["PI3K"]
end
style PI3K fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
style CANCER fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style AKT fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style MTOR fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style AKT_1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style GENES fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Als fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Autophagy fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Mtor fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Cancer fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style PTEN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style PTEN_2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style PTEN_3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style AKT_4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style MTOR_5 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style TNF fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Mtor | associated_with | pathway | 1.00 |
| CANCER | associated_with | disease | 1.00 |
| Stem Cell | regulates | pathway | 1.00 |
| Mtor | activates | pathway | 1.00 |
| Mtor | therapeutic_target | pathway | 1.00 |
| Als | associated_with | disease | 1.00 |
| Hepatocellular Carcinoma | activates | disease | 1.00 |
| Infection | activates | disease | 1.00 |
| Microrna | regulates | pathway | 1.00 |
| Mtor | inhibits | pathway | 1.00 |
| MICROGLIA | activates | gene | 1.00 |
| Mtor | regulates | pathway | 1.00 |
| AKT | associated_with | gene | 1.00 |
| Als | treats | disease | 1.00 |
| Differentiation | activates | pathway | 1.00 |
| ALZHEIMER'S DISEASE | activates | gene | 1.00 |
| RAS | activates | gene | 1.00 |
| AMYLOID | inhibits | gene | 1.00 |
| Breast Cancer | therapeutic_target | disease | 1.00 |
| Differentiation | regulates | pathway | 1.00 |
| Breast Cancer | treats | disease | 1.00 |
| MULTIPLE SCLEROSIS | associated_with | disease | 1.00 |
| Drug Resistance | activates | pathway | 1.00 |
| Breast Cancer | inhibits | disease | 1.00 |
| NEUROINFLAMMATION | activates | gene | 1.00 |
| Immunotherapy | therapeutic_target | pathway | 1.00 |
| Pi3K/Akt | inhibits | pathway | 1.00 |
| Insulin Resistance | activates | disease | 1.00 |
| Metastasis | activates | pathway | 1.00 |
| Invasion | activates | pathway | 1.00 |
| Pi3K/Akt | therapeutic_target | pathway | 1.00 |
| HIF | activates | gene | 1.00 |
| Invasion | therapeutic_target | pathway | 1.00 |
| AGING | activates | gene | 1.00 |
| AMPK | regulates | gene | 1.00 |
| NEUROINFLAMMATION | therapeutic_target | gene | 1.00 |
| Cancer | treats | disease | 1.00 |
| CANCER | treats | gene | 1.00 |
| NF-ΚB | therapeutic_target | gene | 1.00 |
| Epithelial-Mesenchymal Transition | regulates | pathway | 1.00 |
| Metastasis | regulates | pathway | 1.00 |
| Pi3K/Akt | activates | pathway | 1.00 |
| Differentiation | therapeutic_target | pathway | 1.00 |
| Metastasis | therapeutic_target | pathway | 1.00 |
| Neurodegeneration | regulates | disease | 1.00 |
| ALZHEIMER | activates | gene | 1.00 |
| Drug Resistance | therapeutic_target | pathway | 1.00 |
| Pi3K/Akt | regulates | pathway | 1.00 |
| ALZHEIMER | therapeutic_target | gene | 1.00 |
| Wnt | associated_with | pathway | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NEURODEGENERATION | activates | gene | 1.00 |
| NF-KB | associated_with | protein | 1.00 |
| ROS | regulates | process | 1.00 |
| AKT | regulates | gene | 1.00 |
| MTOR | activates | gene | 1.00 |
| AUTOPHAGY | therapeutic_target | gene | 1.00 |
| TNF | inhibits | gene | 1.00 |
| PTEN | inhibits | gene | 1.00 |
| AKT | inhibits | gene | 1.00 |
| AKT | activates | gene | 1.00 |
| MTOR | inhibits | gene | 1.00 |
| PTEN | therapeutic_target | gene | 1.00 |
| APOPTOSIS | associated_with | gene | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | disease | 1.00 |
| AKT | targets | gene | 1.00 |
| STAT3 | therapeutic_target | gene | 1.00 |
| PTEN | regulates | gene | 1.00 |
| ROS | activates | gene | 1.00 |
| NEURODEGENERATION | targets | gene | 1.00 |
| PTEN | activates | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| OXIDATIVE STRESS | therapeutic_target | gene | 1.00 |
| OXIDATIVE STRESS | inhibits | gene | 1.00 |
| NEURODEGENERATION | associated_with | gene | 1.00 |
| MIRNAS | therapeutic_target | gene | 1.00 |
| AUTOPHAGY | associated_with | gene | 1.00 |
| APOPTOSIS | targets | gene | 1.00 |
| INSULIN RESISTANCE | activates | gene | 1.00 |
| MTOR | regulates | gene | 1.00 |
| AMYLOID | associated_with | protein | 1.00 |
| APOPTOSIS | inhibits | gene | 1.00 |
| TNF | activates | gene | 1.00 |
| CASP3 | associated_with | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| AKT | associated_with | gene | 1.00 |
| MTOR | associated_with | gene | 1.00 |
| NEURODEGENERATION | regulates | gene | 1.00 |
| AKT1 | targets | gene | 1.00 |
| GAIN | therapeutic_target | gene | 1.00 |
| TNF | therapeutic_target | gene | 1.00 |
| ERK | therapeutic_target | gene | 1.00 |
| PARKINSON'S DISEASE | associated_with | gene | 0.98 |
| AMPK | associated_with | gene | 0.98 |
| alpelisib | inhibits | drug | 0.95 |
| AFB1 | inhibits | drug | 0.95 |
| MTOR SIGNALING | activates | process | 0.95 |
| MTOR SIGNALING | regulates | process | 0.95 |
| Gnetupendin A | targets | compound | 0.95 |
| AKT1 | associated_with | gene | 0.92 |
| phillygenin | activates | drug | 0.92 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TREM2-DAP12 Signalosome Enhancement — Boosting PI3K-AKT-mTOR | 0.718 | Alzheimer's disease | TREM2 agonism vs antagonism in DAM micro |
| CD44-Mediated Src/PI3K/Akt Signaling Cascade | 0.470 | neuroinflammation | What molecular mechanisms mediate SPP1-i |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-12 | 3 hypotheses Top: 0.887
neurodegeneration | 2026-04-04 | 15 hypotheses Top: 0.814
neurodegeneration | 2026-04-03 | 45 hypotheses Top: 0.990
neurodegeneration | 2026-04-02 | 5 hypotheses Top: 0.761
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.703
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Single-cell RNA sequencing of microglial states in AD hippocampus | exploratory | Alzheimer's disease | 0.850 | 0.00 | AD mouse hippocampus | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.79 · 2026-04-12
closed · Rounds: 4 · Score: 0.90 · 2026-04-12
closed · Rounds: 4 · Score: 0.69 · 2026-04-12
closed · Rounds: 7 · Score: 0.91 · 2026-04-10
closed · Rounds: 4 · Score: 0.91 · 2026-04-06
closed · Rounds: 4 · Score: 0.87 · 2026-04-06
closed · Rounds: 4 · Score: 0.95 · 2026-04-06
closed · Rounds: 3 · Score: 0.95 · 2026-04-04
closed · Rounds: 4 · Score: 0.95 · 2026-04-03
closed · Rounds: 3 · Score: 0.68 · 2026-04-02
Hypotheses and analyses mentioning PI3K in their description or question text
No additional research found