gene

RHEB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RHEB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

511Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

RHEB is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, inhibits. Associated with ALS, Aging, Als. Connected to 186 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RHEB
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	cortex, Hippocampus, Frontal Lobe
Pathways	mTOR, mtor, mTOR signaling, mTOR Pathway
UniProt ID	Q15382
GeneCards	RHEB
Human Protein Atlas	RHEB
Associated Diseases	Als, Carcinoma, epilepsy, Ms
Known Drugs/Compounds	rapamycin
Interactions	Actin, Akt, AKT, AKT1, AKT1S1, AKT3
KG Connections	511 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: RHEB — AlphaFold Q15382 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RHEB Gene

gene · 555 words

→

RHEB Protein

protein · 587 words

→

Pathway Diagram

flowchart TD
    RHEB["RHEB
GTPase"]
    mTOR["mTOR
Kinase"]
    RPTOR["RPTOR
mTOR Component"]
    
    TSC1_TSC2["TSC1/TSC2
Complex"]
    LRRK2["LRRK2
Kinase"]
    
    ATG16L1["ATG16L1
Autophagy"]
    BECN1["BECN1
Autophagy Initiator"]
    LC3["LC3
Autophagosome
Marker"]
    RB1CC1["RB1CC1/FIP200
Autophagy
Regulator"]
    GABARAP["GABARAP
Autophagy
Modifier"]
    
    EIF2AK3["EIF2AK3/PERK
ER Stress
Kinase"]
    ERN1["ERN1/IRE1
ER Stress
Sensor"]
    EIF2A["EIF2A
Translation
Factor"]
    
    STAT3["STAT3
Transcription
Factor"]
    IFNG["IFNG
Inflammatory
Cytokine"]
    
    ALS["ALS
Motor Neuron
Disease"]
    MS["MS
Autoimmune
Disease"]
    
    RHEB -->|"activates"| mTOR
    mTOR -->|"complexes_with"| RPTOR
    TSC1_TSC2 -->|"inhibits"| RHEB
    
    mTOR -->|"inhibits"| ATG16L1
    mTOR -->|"inhibits"| BECN1
    BECN1 -->|"initiates"| LC3
    ATG16L1 -->|"regulates"| LC3
    RB1CC1 -->|"facilitates"| BECN1
    LC3 -->|"conjugates_with"| GABARAP
    
    LRRK2 -->|"modulates"| RHEB
    LRRK2 -->|"affects"| ATG16L1
    
    EIF2AK3 -->|"phosphorylates"| EIF2A
    ERN1 -->|"coordinates_with"| EIF2AK3
    mTOR -->|"regulates"| EIF2A
    
    STAT3 -->|"responds_to"| IFNG
    RHEB -->|"modulates"| STAT3
    
    RHEB -->|"contributes_to"| ALS
    RHEB -->|"therapeutic_target"| MS
    
    style RHEB fill:#006494
    style mTOR fill:#ef5350
    style ATG16L1 fill:#1b5e20
    style BECN1 fill:#1b5e20
    style LC3 fill:#1b5e20
    style EIF2AK3 fill:#ef5350
    style ERN1 fill:#ef5350
    style LRRK2 fill:#4a1a6b
    style STAT3 fill:#4a1a6b
    style ALS fill:#5d4400
    style MS fill:#5d4400

Outgoing (274)

Target	Relation	Type	Str
autophagy pathway	participates_in	pathway	0.70
PI3K-AKT-mTOR signaling	participates_in	pathway	0.70
stem cells	expressed_in	cell_type	0.70
mTOR	activates	protein	0.70
Mtor	activates	pathway	0.70
cortex	expressed_in	brain_region	0.70
Als	inhibits	disease	0.65
Als	activates	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
ALS	interacts_with	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Autism	inhibits	disease	0.65
Alzheimer	regulates	disease	0.65
Fibrosis	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Aging	inhibits	disease	0.65
Carcinoma	activates	disease	0.65
Epilepsy	associated_with	disease	0.65
Epilepsy	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Fibrosis	regulates	disease	0.65
Epilepsy	activates	disease	0.65
ALS	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Epilepsy	causes	disease	0.65
Carcinoma	causes	disease	0.65
Als	regulates	disease	0.65
Ms	causes	disease	0.65
PIK3CA	activates	gene	0.60
Neural Progenitor	activates	cell_type	0.60
AKT3	activates	gene	0.60
STAT3	activates	gene	0.60
RICTOR	activates	gene	0.60
RIPK1	activates	gene	0.60
SQSTM1	activates	gene	0.60
STING1	activates	gene	0.60
Akt	regulates	pathway	0.60
Wnt	regulates	pathway	0.60
DEPDC5	activates	gene	0.60
BRAF	associated_with	gene	0.60
PIK3CA	associated_with	gene	0.60
NF1	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
NRAS	associated_with	gene	0.60
EGFR	associated_with	gene	0.60

Incoming (237)

Source	Relation	Type	Str
CASP3	interacts_with	gene	0.60
AKT1	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
CGAS	interacts_with	gene	0.60
CFTR	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
RPS6KB1	interacts_with	gene	0.60
GRB2	interacts_with	gene	0.60
GABARAP	interacts_with	gene	0.60
P38	interacts_with	gene	0.60
PIK3C3	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
IFNG	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
ATF6	interacts_with	gene	0.60
HSPA5	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
EIF2A	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
MAPK14	interacts_with	gene	0.60
MLKL	interacts_with	gene	0.60
TFE3	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
ATG16L1	interacts_with	gene	0.60
FIP200	interacts_with	gene	0.60
EGF	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
RICTOR	interacts_with	gene	0.60
HSP70	interacts_with	gene	0.60
PPARG	interacts_with	gene	0.60
TSC2	activates	gene	0.60
TFEB	activates	gene	0.60
TSC1	therapeutic_target	gene	0.60
TFE3	activates	gene	0.60
MTOR	activates	gene	0.60
STAT3	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60
DEPTOR	interacts_with	gene	0.60
MAVS	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
PTEN	activates	gene	0.60
RPS6	activates	gene	0.60
OPTN	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RHEB in their description or question text

No additional research found