concept

NRBF2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NRBF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

290Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	NRBF2
Key Genes/Proteins	Actin, Akt, AKT1, AKT1S1, AMBRA1, AMPK
Related Diseases	Als, ALS, Alzheimer's disease

Pathway Diagram

graph TD
    NRBF2["NRBF2"]
    style NRBF2 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    NRBF2 -->|"participates in"| PIK3C3([PIK3C3])
    NRBF2 -->|"regulates"| Autophagy["Autophagy"]
    NRBF2 -->|"regulates"| ATG14([ATG14])
    NRBF2 -->|"interacts"| RAB7([RAB7])
    NRBF2 -->|"interacts"| CCZ1_MON1A([CCZ1-MON1A])
    NRBF2 -->|"regulates"| APP([APP])
    NRBF2 -->|"regulates"| autophagosome_maturation["autophagosome maturation"]
    NRBF2 -->|"regulates"| PI3KC3([PI3KC3])
    Apoptosis["Apoptosis"] -->|"regulates"| NRBF2
    Inflammation["Inflammation"] -->|"regulates"| NRBF2
    LC3([LC3]) -->|"interacts"| NRBF2
    CALCOCO2([CALCOCO2]) -->|"interacts"| NRBF2
    ERN1([ERN1]) -->|"interacts"| NRBF2
    LRRK2([LRRK2]) -->|"interacts"| NRBF2
    WNT([WNT]) -->|"interacts"| NRBF2
    RB1([RB1]) -->|"interacts"| NRBF2
    OPTINEURIN([OPTINEURIN]) -->|"interacts"| NRBF2
    FIP200([FIP200]) -->|"interacts"| NRBF2

Outgoing (167)

Target	Relation	Type	Str
PIK3C3	participates_in	gene	0.80
ROS	activates	gene	0.70
PI3K	activates	gene	0.70
oxidative stress response	participates_in	pathway	0.70
PI3K-AKT-mTOR signaling	participates_in	pathway	0.70
STAT3	activates	gene	0.70
autophagy pathway	participates_in	pathway	0.70
MAPK signaling	participates_in	pathway	0.70
stem cells	expressed_in	cell_type	0.70
SQSTM1	activates	gene	0.70
necroptosis	participates_in	pathway	0.70
Alzheimer's disease	associated_with	disease	0.70
ATG14	interacts_with	protein	0.70
PI3KC3	regulates	protein	0.70
RAB7	activates	protein	0.70
autophagosome maturation	activates	process	0.70
APP	regulates	protein	0.70
autophagosome maturation	regulates	process	0.70
ATG14	regulates	protein	0.70
RAB7	interacts_with	protein	0.70
CCZ1-MON1A	interacts_with	protein	0.70
Cancer	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Fibrosis	interacts_with	disease	0.65
CASP3	interacts_with	gene	0.60
P38	interacts_with	gene	0.60
HSP70	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
EIF2A	interacts_with	gene	0.60
RHEB	interacts_with	gene	0.60
CYP1A1	interacts_with	gene	0.60
GCN2	interacts_with	gene	0.60
MAPK14	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
AKT1S1	interacts_with	gene	0.60
GABARAP	interacts_with	gene	0.60
RIPK1	interacts_with	gene	0.60
MAP1LC3A	interacts_with	gene	0.60
GRB2	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
MLKL	interacts_with	gene	0.60
ATP	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60
CFTR	interacts_with	gene	0.60
AND	interacts_with	gene	0.60

Incoming (123)

Source	Relation	Type	Str
Inflammatory Bowel Diseases	associated_with	disease	0.70
ERN1	activates	gene	0.70
MTOR	activates	gene	0.70
LC3	activates	gene	0.70
MAPK	activates	gene	0.70
NLR	activates	gene	0.70
rapamycin	targets	drug	0.70
OPTINEURIN	interacts_with	gene	0.60
FIP200	interacts_with	gene	0.60
AKT1	interacts_with	gene	0.60
ATF6	interacts_with	gene	0.60
CDH1	interacts_with	gene	0.60
EGF	interacts_with	gene	0.60
RAS	interacts_with	gene	0.60
NLR	interacts_with	gene	0.60
IFN	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
DEPTOR	interacts_with	gene	0.60
TFE3	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
RICTOR	interacts_with	gene	0.60
HMGB1	interacts_with	gene	0.60
MLST8	interacts_with	gene	0.60
APC	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
LYSOSOME	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
CGAS	interacts_with	gene	0.60
ROS	interacts_with	gene	0.60
MAPK	interacts_with	gene	0.60
STAT3	interacts_with	gene	0.60
HSPA5	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
PPARG	interacts_with	gene	0.60
RPS6KB1	interacts_with	gene	0.60
GABA	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
MLKL	interacts_with	gene	0.60
RIPK1	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
HSP70	interacts_with	gene	0.60
ATG16L1	interacts_with	gene	0.60
AKT1S1	interacts_with	gene	0.60
RHEB	interacts_with	gene	0.60
GABARAP	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NRBF2 in their description or question text

No additional research found