gene

RHOT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RHOT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

724Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

RHOT1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, associated with. Associated with AD, ALI, ALS. Connected to 225 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RHOT1
Aliases	Page for RHOT1, Page for RHOT1 Protein
Target Class	Protein
Function	Calcium-Dependent GTPase Activity: - MIRO1 hydrolyzes GTP to GDP, regulated by calcium binding to EF-hand domains - Calcium influx through NMDA receptors or voltage-gated calcium channels activates MI
Mechanism of Action	Prioritized from 1 SciDEX hypotheses, including: Miro1-Mediated Mitochondrial Trafficking Enhancement Therapy
Subcellular Localization	</th><td>Outer mitochondrial membrane (OMM)</td></tr>
Druggability	Undruggable (0.23)
Molecular Weight	71.4 kDa
Amino Acids	618 aa
Pathways	mitochondrial homeostasis
Ensembl ID	ENSG00000153823
GeneCards	RHOT1
Human Protein Atlas	RHOT1
Associated Diseases	AD, ALI, Als, Alzheimer, BREAST CANCER
Known Drugs/Compounds	Electroacupuncture
Interactions	ABCD3, ALS, ALZHEIMER, ALZHEIMER DISEASE, AMBRA1, AMPK
SciDEX Target	View Target Profile
SciDEX Hypotheses	Miro1-Mediated Mitochondrial Trafficking Enhanceme
KG Connections	724 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RHOT1 Protein - MIRO1 - Mitochondrial Rho GTPase 1

protein · 1223 words

→

RHOT1 - Mitochondrial Rho GTPase 1

gene · 1136 words

→

Pathway Diagram

graph TD
    RHOT1["RHOT1"] -->|"Interacts With"| Dementia["Dementia"]
    RHOT1["RHOT1"] -->|"Interacts With"| Cardiovascular["Cardiovascular"]
    RHOT1["RHOT1"] -->|"Interacts With"| Als["Als"]
    RHOT1["RHOT1"] -->|"Interacts With"| Alzheimer["Alzheimer"]
    RHOT1["RHOT1"] -->|"Interacts With"| Parkinson["Parkinson"]
    RHOT1["RHOT1"] -->|"Interacts With"| Ms["Ms"]
    RHOT1["RHOT1"] -->|"Activates"| Neurodegeneration["Neurodegeneration"]
    RHOT1["RHOT1"] -->|"Interacts With"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    CAT["CAT"] -->|"Interacts With"| RHOT1["RHOT1"]
    OPTN["OPTN"] -->|"Interacts With"| RHOT1["RHOT1"]
    DNM1L["DNM1L"] -->|"Interacts With"| RHOT1["RHOT1"]
    CANX["CANX"] -->|"Interacts With"| RHOT1["RHOT1"]
    LGALS3["LGALS3"] -->|"Interacts With"| RHOT1["RHOT1"]
    style RHOT1 fill:#8d4900,color:#e0e0e0
    style Dementia fill:#b71c1c,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Alzheimer fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Neurodegeneration fill:#b71c1c,color:#e0e0e0
    style Amyotrophic_Lateral_Sclerosis fill:#b71c1c,color:#e0e0e0
    style CAT fill:#8d4900,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style DNM1L fill:#8d4900,color:#e0e0e0
    style CANX fill:#8d4900,color:#e0e0e0
    style LGALS3 fill:#8d4900,color:#e0e0e0

Outgoing (375)

Target	Relation	Type	Str
Miro1	encodes	protein	1.00
MIRO1	encodes	protein	0.95
Astrocytes	expressed_in	cell_type	0.95
Parkinson'S Disease	associated_with	disease	0.95
Mitochondrial Transfer	regulates	process	0.95
Mitochondrial Transfer	mediates	process	0.95
Neuronal Viability	promotes	phenotype	0.90
Atp Production	regulates	process	0.90
TOM40	regulates	protein	0.90
Cerebral Ischemia-Reperfusion Injury	protects_against	disease	0.90
Epithelial Injury	involved_in	phenotype	0.90
Airway Hyperresponsiveness	protects_against	phenotype	0.85
Induced Pluripotent Stem Cells	involved_in	cell_type	0.85
Asthma	therapeutic_target	disease	0.85
Parkinson's disease	activates	disease	0.80
Parkinson's disease	regulates	disease	0.80
stem cells	expressed_in	cell_type	0.70
apoptosis pathway	participates_in	pathway	0.70
Parkinson's disease	implicated_in	disease	0.70
neural stem cells	regulates	cell_type	0.70
neural stem cells	activates	cell_type	0.70
ALS	interacts_with	disease	0.65
Diabetes	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Obesity	activates	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Inflammation	activates	disease	0.65
Aging	activates	disease	0.65
Depression	activates	disease	0.65
Alzheimer	interacts_with	disease	0.65
Neuroinflammation	activates	disease	0.65
Parkinson	associated_with	disease	0.65
Dementia	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Stroke	activates	disease	0.65
Ms	activates	disease	0.65
Cancer	inhibits	disease	0.65
Als	inhibits	disease	0.65
Als	interacts_with	disease	0.65
Parkinson	encodes	disease	0.65
Als	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Ftd	interacts_with	disease	0.65
Tumor	contributes_to	disease	0.65
Tumor	inhibits	disease	0.65
Cancer	expressed_in	disease	0.65

Incoming (349)

Source	Relation	Type	Str
Astrocytes	expressed_in	cell_type	0.95
h-91bdb9ad	targets	hypothesis	0.90
Crispr/Cas9	targets	mechanism	0.90
Electroacupuncture	targets	drug	0.85
PRKN	regulates	gene	0.70
CALCOCO2	regulates	gene	0.60
BCL2L13	regulates	gene	0.60
ALS	interacts_with	gene	0.60
ATP	interacts_with	gene	0.60
PGAM5	interacts_with	gene	0.60
BIM	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
AMPK	activates	entity	0.60
FTD	activates	entity	0.60
CATALASE	interacts_with	gene	0.60
NLR	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
SESTRIN2	interacts_with	gene	0.60
MIRO1	associated_with	gene	0.60
ALS	activates	entity	0.60
CAT	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
ABCD3	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
BNIP3L	interacts_with	gene	0.60
HIF1A	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
DDIT3	activates	entity	0.60
DISC1	activates	entity	0.60
NLRP3	interacts_with	gene	0.60
PARL	interacts_with	gene	0.60
DRP1	activates	entity	0.60
FUNDC1	interacts_with	gene	0.60
JNK	interacts_with	gene	0.60
RTN3	interacts_with	gene	0.60
EIF2AK3	activates	entity	0.60
EPAS1	activates	entity	0.60
BCL2	activates	entity	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Miro1-Mediated Mitochondrial Trafficking Enhancement Therapy	0.549	neurodegeneration	Mitochondrial transfer between neurons a

Mentioning Analyses (1)

Scientific analyses that reference this entity

Mitochondrial transfer between neurons and glia

neurodegeneration | 2026-04-01 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (15)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Dihuang Yinzi ameliorates post-stroke depression through Miro1 ubiquitination-de [PMID:41850637]	Chang H, Ji Z, Sun Q, Zhou S, Yang Z, Qu	Journal of ethnopharmacology	2026
Miro1 protects against brain injury after CPR in rats by enhancing the effect of [PMID:41153049]	Ma X, Shen M, Hu J, Zhu J, Wang Z, Zhou	Stem cell research & therapy	2025
Parkinson's disease mutant Miro1 causes mitochondrial dysfunction and dopaminerg [PMID:39913247]	Chemla A, Arena G, Sacripanti G, Barmpa	Brain : a journal of neurology	2025
Generation of two induced pluripotent stem cell lines and the corresponding isog [PMID:37364399]	Chemla A, Arena G, Onal G, Walter J, Ber	Stem cell research	2023
Generation of two induced pluripotent stem cell lines and the corresponding isog [PMID:37003181]	Chemla A, Arena G, Saraiva C, Berenguer-	Stem cell research	2023
Harlequin syndrome associated with thoracic epidural anaesthesia. [PMID:35118419]	Persson RM, Tellnes K, Hoven H, Haaverst	Anaesthesia reports	2022
Transmission dynamics of a linear vanA-plasmid during a nosocomial multiclonal o [PMID:34285270]	Fujiya Y, Harada T, Sugawara Y, Akeda Y,	Scientific reports	2021
Generation of R272Q, S156A and K572R RHOT1/Miro1 point mutations in iPSCs from a [PMID:34359002]	Schwarz L, Casadei N, Fitzgerald JC	Stem cell research	2021
High resolution spatiotemporal patterns of seawater temperatures across the Beli [PMID:33199700]	Helmuth B, Leichter JJ, Rotjan RD, Casti	Scientific data	2020
The Emerging Role of RHOT1/Miro1 in the Pathogenesis of Parkinson's Disease. [PMID:33041957]	Grossmann D, Berenguer-Escuder C, Chemla	Frontiers in neurology	2020
DPYD6 plays an important role in fluoropyrimidine toxicity in addition to DPYD [PMID:30723313]	Del Re M, Cinieri S, Michelucci A, Salva	The pharmacogenomics journal	2019
Genome Sequence of the K139-Like Phage VcP032 Originating from the Vibrio choler [PMID:27445393]	Jäckel C, Strauch E, Hammerl JA	Genome announcements	2016
Clarithromycin as a chiral selector for enantioseparation of basic compounds in [PMID:25100556]	Lebedeva MV, Prokhorova AF, Shapovalova	Electrophoresis	2014
Medial prefrontal D1 dopamine neurons control food intake. [PMID:24441680]	Land BB, Narayanan NS, Liu RJ, Gianessi	Nature neuroscience	2014
DISC1 complexes with TRAK1 and Miro1 to modulate anterograde axonal mitochondria [PMID:24092329]	Ogawa F, Malavasi EL, Crummie DK, Eykele	Human molecular genetics	2014

Debates (2)

Multi-agent debates referencing this entity

Mitochondrial transfer between neurons and glia?

closed · Rounds: 4 · Score: 0.71 · 2026-04-12

Analysis question not specified

closed · Rounds: 4 · Score: 0.81 · 2026-04-06

Related Research

Hypotheses and analyses mentioning RHOT1 in their description or question text

No additional research found