protein

P38

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P38: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1695Connections

1Hypotheses

6Analyses

50Outgoing

50Incoming

1Experiments

6Debates

Summary

P38 is a protein involved in neurodegeneration research. Key relationships include: activates, regulates, interacts with. Associated with ALS, Aging, Als. Connected to 1019 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	P38
Chromosome	MAPK14: 6p21.31, MAPK11: 22q13.13, MAPK12: 15q21.2, MAPK13: 6p21.31
Protein Type	Kinase
Function	Upstream stress signals: Pro-inflammatory cytokines (IL-1β, TNF-α), oxidative stress, UV radiation, heat shock, and ischemia trigger activation
Primary Expression	neurons, microglia, and astrocytes
Molecular Weight	~38-40 kDa per isoform
Pathways	Akt, Apoptosis, Autophagy, Differentiation, Glycolysis
GeneCards	P38
Human Protein Atlas	P38
Associated Diseases	Als, Alzheimer, Alzheimer's disease, Cancer, Carcinoma
Known Drugs/Compounds	Benzimidazole-aminopyrimidine hybrids, Gold nanoparticle, N-ACETYLCYSTEINE, p38α MAPK inhibitor, Paeoniflorin, RAPAMYCIN
Interactions	ACOX1, ACSL4, AGING, AHR, AIM2, AKT
KG Connections	1682 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

p38 MAPK Protein

protein · 1342 words

→

Pathway Diagram

graph TD
    P38["P38"] -->|"phosphorylates"| FOXN3["FOXN3"]
    P38["P38"] -->|"regulates"| NF_KB["NF-KB"]
    P38["P38"] -->|"associated"| INFLAMMATION["INFLAMMATION"]
    P38["P38"] -->|"interacts"| Cancer["Cancer"]
    P38["P38"] -->|"interacts"| Fibrosis["Fibrosis"]
    P38["P38"] -->|"interacts"| Als["Als"]
    GABARAP["GABARAP"] -->|"interacts"| P38["P38"]
    HSPA1A["HSPA1A"] -->|"regulates"| P38["P38"]
    ATG5["ATG5"] -->|"activates"| P38["P38"]
    GABARAP_1["GABARAP"] -->|"activates"| P38["P38"]
    style P38 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1021)

Target	Relation	Type	Str
INFLAMMATION	activates	gene	1.00
INFLAMMATION	inhibits	gene	1.00
Infection	activates	disease	1.00
Inflammation	inhibits	disease	1.00
Tumor	activates	disease	1.00
Mapk	inhibits	pathway	1.00
Inflammation	activates	disease	1.00
Cancer	activates	disease	1.00
Mapk	therapeutic_target	pathway	1.00
Als	inhibits	disease	1.00
P38 Mapk	activates	pathway	1.00
Als	therapeutic_target	disease	1.00
Als	activates	disease	1.00
Mapk	activates	pathway	1.00
JUN	activates	gene	1.00
AKT	activates	gene	1.00
CANCER	activates	gene	1.00
Autophagy	activates	pathway	1.00
Apoptosis	activates	pathway	1.00
Inflammation	regulates	disease	0.95
Cancer	therapeutic_target	disease	0.95
Tumor	inhibits	disease	0.95
Inflammation	therapeutic_target	disease	0.95
FOXN3	phosphorylates	gene	0.95
FOXN3	phosphorylates	protein	0.94
p38α MAPK inhibitor	inhibits	compound	0.90
p38α	part_of	protein	0.90
MAPK	upstream_of	pathway	0.90
NF-KB	regulates	gene	0.90
TNF-Α	activates	gene	0.90
Nf-Κb	activates	pathway	0.90
Nf-Κb	inhibits	pathway	0.90
Oxidative Stress	inhibits	pathway	0.90
Neurodegeneration	activates	disease	0.85
Tumor	therapeutic_target	disease	0.85
Tumor	regulates	disease	0.85
Neuroinflammation	activates	disease	0.85
ATF2	activates	protein	0.85
INFLAMMATION	associated_with	gene	0.85
Neurodegeneration	regulates	disease	0.85
Cancer	inhibits	disease	0.85
Benzimidazole-aminopyrimidine hybrids	inhibits	compound	0.80
TNF-α	regulates	protein	0.80
TDP-43	associated_with	protein	0.80
IL-1β	regulates	protein	0.80
Alzheimer's disease	associated_with	disease	0.80
Benzimidazole-aminopyrimidine hybrids	binds	compound	0.80
Nf-Κb	therapeutic_target	pathway	0.80
AUTOPHAGY	activates	gene	0.80
INFLAMMATION	therapeutic_target	gene	0.80

Incoming (674)

Source	Relation	Type	Str
JNK	activates	gene	1.00
APOPTOSIS	activates	gene	1.00
ERK	activates	gene	1.00
ERK	inhibits	gene	1.00
ERK1	activates	gene	1.00
CYTOKINES	inhibits	gene	1.00
CYTOKINES	activates	gene	1.00
NF-ΚB	inhibits	gene	1.00
PI3K	activates	gene	1.00
PRMTM1	regulates	gene	0.90
APOPTOSIS	inhibits	gene	0.90
JNK	inhibits	gene	0.90
NF-ΚB	activates	gene	0.90
ROS	activates	gene	0.90
Paeoniflorin	targets	compound	0.88
Paeoniflorin	targets	compound	0.85
DUSP8	associated_with	gene	0.80
BECN1	activates	gene	0.80
ERK1	regulates	gene	0.80
PI3K	therapeutic_target	gene	0.80
NEUROTOXICITY	activates	gene	0.80
TNF	activates	gene	0.80
NEURODEGENERATION	regulates	gene	0.80
OXIDATIVE STRESS	therapeutic_target	gene	0.80
TNF	inhibits	gene	0.80
IL-6	activates	gene	0.80
AUTOPHAGY	activates	gene	0.80
NF-ΚB	therapeutic_target	gene	0.80
Baicalin	interacts_with	compound	0.75
JNK	regulates	gene	0.70
PI3K	regulates	gene	0.70
ERK	regulates	gene	0.70
PTEN	activates	gene	0.70
ERK1	associated_with	gene	0.70
SLC7A11	activates	gene	0.70
BAX	expressed_in	gene	0.70
TAU	activates	gene	0.70
ALZHEIMER	activates	gene	0.70
TNF	expressed_in	gene	0.70
STAT3	activates	gene	0.70
NEURODEGENERATION	treats	gene	0.70
Parkin	interacts_with	protein	0.70
INFLAMMATION	regulates	gene	0.70
INFLAMMATION	inhibits	gene	0.70
NADPH	inhibits	drug	0.70
SOD1	phosphorylates	gene	0.70
SOD1	causes	gene	0.70
Parkin	activates	protein	0.70
APOPTOSIS	regulates	gene	0.70
IL-6	expressed_in	gene	0.70

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
p38α Inhibitor and PRMT1 Activator Combination to Restore Ph	0.848	neurodegeneration	What is the therapeutic window between i

Mentioning Analyses (6)

Scientific analyses that reference this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
MAPK pathway inhibition by QTJD through butyrate mechanism	exploratory	Mycoplasma pneumoniae pneumoni	0.900	0.00	Mouse macrophages	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (6)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning P38 in their description or question text

No additional research found

P38

Understanding Entity Pages

Summary

Wiki Pages (1)

p38 MAPK Protein

Pathway Diagram

Outgoing (1021)

Incoming (674)

Targeting Hypotheses (1)

Mentioning Analyses (6)

How do neurodegeneration gene expression patterns in SEA-AD differ from other po

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Synaptic pruning by microglia in early AD

Digital biomarkers and AI-driven early detection of neurodegeneration

Senolytic therapy for age-related neurodegeneration

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

Experiments (1)

Related Papers (0)

Debates (6)

Microglia activate astrocytes via IL-1alpha/TNF/C1q, and reactive astrocytes fee

Can speech, gait, retinal imaging, sleep, and smartphone data detect neurodegene

Senolytics targeting p16/p21+ senescent astrocytes and microglia may reduce SASP

Synaptic pruning by microglia in early AD

How do neurodegeneration gene expression patterns in SEA-AD differ from other po

What gene expression changes in the aging mouse brain predict neurodegenerative

Related Research