gene

BCL2L13

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BCL2L13: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

719Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

BCL2L13 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with AD, ALI, ALS. Connected to 323 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	BCL2L13
Full Name	BCL2 Like 13
Chromosome	22q11.21
Protein Type	Mitochondrial Outer Membrane Protein
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	32 kDa
Pathways	Apoptosis, Er Stress, Immune Response, MAPK signaling, Mitochondrial Function
UniProt ID	[Q9HAW5](https://www.uniprot.org/uniprot/Q9HAW5)
GeneCards	BCL2L13
Human Protein Atlas	BCL2L13
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Interactions	ABCD3, Actin, AGING, ALS, ALZHEIMER, ALZHEIMER DISEASE
KG Connections	719 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

BCL2L13

gene · 640 words

→

Pathway Diagram

graph TD
    BCL2L13["BCL2L13"] -->|"Interacts With"| Dementia["Dementia"]
    BCL2L13["BCL2L13"] -->|"Interacts With"| Cardiovascular["Cardiovascular"]
    BCL2L13["BCL2L13"] -->|"Interacts With"| Als["Als"]
    BCL2L13["BCL2L13"] -->|"Interacts With"| Alzheimer["Alzheimer"]
    BCL2L13["BCL2L13"] -->|"Interacts With"| Parkinson["Parkinson"]
    BCL2L13["BCL2L13"] -->|"Interacts With"| Ms["Ms"]
    BCL2L13["BCL2L13"] -->|"Associated With"| Ischemia["Ischemia"]
    BCL2L13["BCL2L13"] -->|"Inhibits"| Aging["Aging"]
    CAT["CAT"] -->|"Interacts With"| BCL2L13["BCL2L13"]
    OPTN["OPTN"] -->|"Interacts With"| BCL2L13["BCL2L13"]
    DNM1L["DNM1L"] -->|"Interacts With"| BCL2L13["BCL2L13"]
    CANX["CANX"] -->|"Interacts With"| BCL2L13["BCL2L13"]
    LGALS3["LGALS3"] -->|"Interacts With"| BCL2L13["BCL2L13"]
    style BCL2L13 fill:#8d4900,color:#e0e0e0
    style Dementia fill:#b71c1c,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Alzheimer fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Ischemia fill:#b71c1c,color:#e0e0e0
    style Aging fill:#b71c1c,color:#e0e0e0
    style CAT fill:#8d4900,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style DNM1L fill:#8d4900,color:#e0e0e0
    style CANX fill:#8d4900,color:#e0e0e0
    style LGALS3 fill:#8d4900,color:#e0e0e0

Outgoing (497)

Target	Relation	Type	Str
apoptosis pathway	participates_in	pathway	0.70
ubiquitin-proteasome	participates_in	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
Tumor	activates	disease	0.65
Cardiovascular	degrades	disease	0.65
Glioblastoma	inhibits	disease	0.65
Ischemia	activates	disease	0.65
Ftd	interacts_with	disease	0.65
Als	activates	disease	0.65
Stroke	expressed_in	disease	0.65
Tumor	biomarker_for	disease	0.65
Aging	degrades	disease	0.65
Inflammation	activates	disease	0.65
Tumor	inhibits	disease	0.65
Ms	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Cardiovascular	inhibits	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Ms	associated_with	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
Cancer	associated_with	disease	0.65
Ischemia	regulates	disease	0.65
Carcinoma	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Ms	regulates	disease	0.65
ALS	interacts_with	disease	0.65
Infection	activates	disease	0.65
Als	expressed_in	disease	0.65
Als	interacts_with	disease	0.65
Ischemia	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Aging	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Cardiovascular	associated_with	disease	0.65
Lymphoma	inhibits	disease	0.65
Ms	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Actin	interacts_with	protein	0.60
ROS	activates	gene	0.60
Alzheimer	associated_with	disease	0.60
Fus	interacts_with	protein	0.60
NLR	activates	gene	0.60
Interferon	interacts_with	protein	0.60
ALS	associated_with	disease	0.60
GFP	interacts_with	gene	0.60

Incoming (222)

Source	Relation	Type	Str
DDIT3	interacts_with	gene	0.60
EMD	interacts_with	gene	0.60
CHOP	interacts_with	gene	0.60
PTEN	interacts_with	gene	0.60
ATG	activates	gene	0.60
NBR1	interacts_with	gene	0.60
ATP	activates	gene	0.60
DRP1	interacts_with	gene	0.60
SESTRIN2	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
ALS	regulates	gene	0.60
AMPK	regulates	gene	0.60
ATG	regulates	gene	0.60
ATP	regulates	gene	0.60
BCL2	interacts_with	gene	0.60
BCL2L11	interacts_with	gene	0.60
CAT	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
SNCAIP	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
FMR1	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
FAM134B	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
EPAS1	interacts_with	gene	0.60
MIRO1	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
MUL1	interacts_with	gene	0.60
BNIP3	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60
EIF2S1	interacts_with	gene	0.60
RIPK3	interacts_with	gene	0.60
MAPK8	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning BCL2L13 in their description or question text

No additional research found