pathway

JAK-STAT signaling

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about JAK-STAT signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

179Connections

0Hypotheses

0Analyses

16Outgoing

50Incoming

0Experiments

0Debates

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🔀 Pathway Info

Name	JAK-STAT signaling
Key Genes/Proteins	AKT, AKT1, ALPK1, AMPK, APC, APOE
Related Diseases	ALS, Alzheimer's disease, autism spectrum disorder
Related Pathways	autophagy pathway

Pathway Diagram

graph TD
    JAK_STAT_signaling["JAK-STAT signaling"] -->|"crosstalk with"| NF_kB_signaling["NF-kB signaling"]
    style NF_kB_signaling fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    JAK_STAT_signaling["JAK-STAT signaling"] -->|"active in"| microglia["microglia"]
    style microglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    JAK_STAT_signaling["JAK-STAT signaling"] -->|"crosstalk with"| TGF_beta_signaling["TGF-beta signaling"]
    style TGF_beta_signaling fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    JAK_STAT_signaling["JAK-STAT signaling"] -->|"crosstalk with"| PI3K_AKT_mTOR_signaling["PI3K-AKT-mTOR signaling"]
    style PI3K_AKT_mTOR_signaling fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    JAK_STAT_signaling["JAK-STAT signaling"] -->|"active in"| astrocytes["astrocytes"]
    style astrocytes fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    JAK_STAT_signaling["JAK-STAT signaling"] -->|"crosstalk with"| autophagy_pathway["autophagy pathway"]
    style autophagy_pathway fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    JAK_STAT_signaling["JAK-STAT signaling"] -->|"crosstalk with"| necroptosis["necroptosis"]
    style necroptosis fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    PI3K["PI3K"] -->|"participates in"| JAK_STAT_signaling["JAK-STAT signaling"]
    style PI3K fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    STAT3["STAT3"] -->|"participates in"| JAK_STAT_signaling["JAK-STAT signaling"]
    style STAT3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    JAK["JAK"] -->|"participates in"| JAK_STAT_signaling["JAK-STAT signaling"]
    style JAK fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    neuroinflammation["neuroinflammation"] -->|"involves"| JAK_STAT_signaling["JAK-STAT signaling"]
    style neuroinflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    MAPK["MAPK"] -->|"participates in"| JAK_STAT_signaling["JAK-STAT signaling"]
    style MAPK fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style JAK_STAT_signaling fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (16)

Target	Relation	Type	Str
neural stem cells	active_in	cell_type	0.90
NF-kB signaling	crosstalk_with	pathway	0.90
microglia	active_in	cell_type	0.90
PI3K-AKT-mTOR signaling	crosstalk_with	pathway	0.80
astrocytes	active_in	cell_type	0.80
TGF-beta signaling	crosstalk_with	pathway	0.80
unfolded protein response	crosstalk_with	pathway	0.70
autophagy pathway	crosstalk_with	pathway	0.70
necroptosis	crosstalk_with	pathway	0.70
neurons	active_in	cell_type	0.70
dendritic cells	active_in	cell_type	0.70
macrophages	active_in	cell_type	0.60
hippocampus	active_in	brain_region	0.60
lipid metabolism	crosstalk_with	pathway	0.60
MAPK signaling	crosstalk_with	pathway	0.60
STAT3	activates	gene	0.35

Incoming (163)

Source	Relation	Type	Str
PI3K	participates_in	gene	0.90
STAT3	participates_in	gene	0.90
neuroinflammation	involves	disease	0.90
JAK	participates_in	gene	0.90
depression	involves	disease	0.80
TNF	participates_in	gene	0.80
TLR	participates_in	gene	0.80
JAK2	participates_in	gene	0.80
AKT	participates_in	gene	0.80
MAPK	participates_in	gene	0.80
astrocytes	active_in	cell_type	0.75
microglia	active_in	cell_type	0.75
IL-6	participates_in	gene	0.75
IL6	participates_in	gene	0.70
NLR	participates_in	gene	0.70
SRC	participates_in	gene	0.70
ERN1	participates_in	gene	0.70
epilepsy	involves	disease	0.70
neurodegeneration	involves	disease	0.70
JAK1	participates_in	gene	0.70
STAT1	participates_in	gene	0.70
IFN	participates_in	gene	0.70
HMGB1	participates_in	gene	0.70
TFEB	participates_in	gene	0.70
MTOR	participates_in	gene	0.70
JNK	participates_in	gene	0.70
EGFR	participates_in	gene	0.70
AMPK	participates_in	gene	0.70
EGF	participates_in	gene	0.70
LC3	participates_in	gene	0.70
SQSTM1	participates_in	gene	0.70
ROS	participates_in	gene	0.70
SOCS3	participates_in	gene	0.65
IL-10	participates_in	gene	0.65
RIPK1	participates_in	gene	0.60
obesity	involves	disease	0.60
PDGFRB	participates_in	gene	0.60
STAT2	participates_in	gene	0.60
IFNAR2	participates_in	gene	0.60
STAT6	participates_in	gene	0.60
PSEN	participates_in	gene	0.60
GABARAP	participates_in	gene	0.60
RB1CC1	participates_in	gene	0.60
MAPK14	participates_in	gene	0.60
FIP200	participates_in	gene	0.60
DDIT3	participates_in	gene	0.60
EIF2AK3	participates_in	gene	0.60
BRD4	participates_in	gene	0.60
HDAC3	participates_in	gene	0.60
TLR2	participates_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning JAK-STAT signaling in their description or question text

No additional research found