gene

PIK3C3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PIK3C3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1112Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

PIK3C3 (VPS34) is the catalytic subunit of the class III phosphatidylinositol 3-kinase (PI3K-III), essential for autophagy initiation, endosomal trafficking, lysosomal function, and cellular clearance of protein aggregates in neurodegenerative diseases.

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🧬 Gene Info

Gene Symbol	PIK3C3
Aliases	VPS34
Chromosome	18q12.3
Protein Family	Class III Phosphoinositide 3-kinase (PI3K3C)
Function	PIK3C3 contributes to lysosomal biogenesis and function through its role in autophagosome-lysosome fusion. The protein interacts with the HOPS complex via VPS34-generated PI3P
Subcellular Localization	Cytosol, endosomal membrane, phagophore
Molecular Weight	100 kDa
Amino Acids	887 aa
Exons	32
Pathways	PI3K
UniProt ID	Q8N3F7
Ensembl ID	ENSG00000055070
GeneCards	PIK3C3
Human Protein Atlas	PIK3C3
Associated Diseases	AD, ADH, Als, Alzheimer, AMI
Known Drugs/Compounds	rapamycin
Interactions	ACAT1, ACETYL-COA, AKT, AKT1, AKT1S1, ALZHEIMER
KG Connections	1112 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: PIK3C3 — AlphaFold Q8N3F7 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    PIK3C3(["PIK3C3"])
    BECN1(["BECN1"])
    Sertoli_Cell["Sertoli Cell"]
    AUTOPHAGY["AUTOPHAGY"]
    Sertoli_Cell_Polarity("Sertoli Cell Polarity")
    autophagy["autophagy"]
    PARKINSON_S_DISEASE(["PARKINSON'S DISEASE"])
    Spautin_1["Spautin-1"]
    CLU(["CLU"])
    SCIN(["SCIN"])
    BRSK2(["BRSK2"])
    SRSF1(["SRSF1"])
    NRBF2(["NRBF2"])
    Autophagy["Autophagy"]

    BECN1 -->|"associated with"| PIK3C3
    PIK3C3 -->|"expressed in"| Sertoli_Cell
    PIK3C3 -->|"regulates"| AUTOPHAGY
    PIK3C3 -->|"associated with"| Sertoli_Cell_Polarity
    PIK3C3 -->|"activates"| autophagy
    PIK3C3 -->|"associated with"| PARKINSON_S_DISEASE
    PIK3C3 -->|"regulates"| Sertoli_Cell_Polarity
    Spautin_1 -->|"associated with"| PIK3C3
    CLU -->|"activates"| PIK3C3
    PIK3C3 -->|"associated with"| SCIN
    PIK3C3 -->|"associated with"| Sertoli_Cell
    BRSK2 -->|"associated with"| PIK3C3
    SRSF1 -->|"binds"| PIK3C3
    NRBF2 -->|"participates in"| PIK3C3
    PIK3C3 -->|"regulates"| Autophagy

    style PIK3C3 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (621)

Target	Relation	Type	Str
macroautophagy	regulates	process	0.95
Autophagy	associated_with	process	0.95
Sertoli Cell	expressed_in	cell_type	0.95
AUTOPHAGY	regulates	pathway	0.92
Sertoli Cell Polarity	associated_with	phenotype	0.92
SCIN	regulates	gene	0.90
Sertoli Cell Polarity	regulates	phenotype	0.90
Spermatogenesis	involved_in	process	0.90
neural stem cells	activates	cell_type	0.90
neural stem cells	regulates	cell_type	0.90
autophagy	activates	pathway	0.90
PARKINSON'S DISEASE	associated_with	gene	0.90
Protein Kinase Activity	involved_in	process	0.85
Sertoli Cells	expressed_in	cell_type	0.85
spermiogenesis	regulates	process	0.85
SCIN	associated_with	gene	0.80
HDAC6	phosphorylates	protein	0.80
TFEB	regulates	gene	0.80
epigenetic regulation	participates_in	pathway	0.80
Sertoli Cell	associated_with	cell_type	0.80
autophagy pathway	participates_in	pathway	0.80
BECN1	regulates	gene	0.80
MTOR	associated_with	gene	0.80
Autophagy	regulates	pathway	0.80
Mtor	associated_with	pathway	0.80
AUTOPHAGY	activates	gene	0.80
Autophagy	activates	pathway	0.80
Als	activates	disease	0.75
Parkinson	activates	disease	0.75
Parkinson	associated_with	disease	0.75
RB1CC1	associated_with	gene	0.70
RAS	activates	gene	0.70
RUBCN	regulates	gene	0.70
AMPK	associated_with	gene	0.70
ATG	associated_with	gene	0.70
NBR1	associated_with	gene	0.70
BECN1	activates	gene	0.70
MITOCHONDRIA	activates	gene	0.70
Mitophagy	activates	pathway	0.70
LYSOSOME	regulates	gene	0.70
WIPI2	associated_with	gene	0.70
MTORC1	activates	gene	0.70
AMPK signaling	participates_in	pathway	0.70
RB1	activates	gene	0.70
MITOPHAGY	activates	gene	0.70
AUTOPHAGY	associated_with	gene	0.70
Parkinson's disease	regulates	disease	0.70
Autophagy	interacts_with	pathway	0.70
RB1	regulates	gene	0.70
SQSTM1	regulates	gene	0.70

Incoming (491)

Source	Relation	Type	Str
BECN1	associated_with	gene	1.00
Acetylation	modulates	process	0.90
Spautin-1	associated_with	compound	0.90
VCP	interacts_with	gene	0.90
NRBF2	participates_in	gene	0.80
rapamycin	targets	drug	0.80
BRSK2	associated_with	protein	0.80
HDAC6	regulates	gene	0.80
ATG	activates	gene	0.80
SRSF1	binds	protein	0.80
GABA	regulates	gene	0.70
ATG5	activates	gene	0.70
AMPK	regulates	gene	0.70
GABARAP	associated_with	gene	0.70
LC3	associated_with	gene	0.70
AR	activates	gene	0.70
AUTOPHAGY	associated_with	gene	0.70
RB1	associated_with	gene	0.70
PARKINSON	associated_with	gene	0.70
FIP200	regulates	gene	0.70
SQSTM1	associated_with	gene	0.70
OPTN	associated_with	gene	0.70
GABARAP	regulates	gene	0.70
CALCOCO2	associated_with	gene	0.70
TFEB	associated_with	gene	0.70
AUTOPHAGY	interacts_with	gene	0.70
OPTN	regulates	gene	0.70
NBR1	regulates	gene	0.70
EGF	interacts_with	gene	0.60
MLST8	interacts_with	gene	0.60
RICTOR	interacts_with	gene	0.60
P38	interacts_with	gene	0.60
VPS35	associated_with	gene	0.60
VPS13D	associated_with	gene	0.60
GBA	associated_with	gene	0.60
VPS11	associated_with	gene	0.60
ATG7	activates	gene	0.60
PI3K	activates	gene	0.60
FOXO3	associated_with	gene	0.60
BRD4	associated_with	gene	0.60
RPS6	regulates	gene	0.60
LAMP1	regulates	gene	0.60
ESR2	associated_with	gene	0.60
EIF2AK2	therapeutic_target	gene	0.60
DDIT3	phosphorylates	entity	0.60
DEPTOR	phosphorylates	entity	0.60
EGF	phosphorylates	entity	0.60
EGFR	phosphorylates	entity	0.60
EIF2A	phosphorylates	entity	0.60
EIF2AK3	phosphorylates	entity	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PIK3C3 in their description or question text

No additional research found