protein

RB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1668Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

RB1 is a protein involved in neurodegeneration research. Key relationships include: interacts with, associated with, therapeutic target. Associated with AD, ALI, ALS. Connected to 840 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	RB1
Full Name	Retinoblastoma 1
Chromosome	13q14.2
Function	is a critical tumor suppressor gene with important functions in the nervous system.
Pathways	Akt, Apoptosis, Autophagy, Dna Methylation, E2F pathway
UniProt ID	P06400
NCBI Gene ID	5925
Ensembl ID	ENSG00000139687
OMIM	180200
GeneCards	RB1
Human Protein Atlas	RB1
N-terminal domain	Involved in protein-protein interactions
Pocket domain	Binds E2F transcription factors; target for viral oncoproteins
C-terminal domain	Regulates pocket function and protein stability
Cell cycle regulation	Controls neuronal cell cycle exit during development[@liu2019]
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	rapamycin, RAPAMYCIN
Interactions	ABCD3, ACAT1, ACHE, ACSL4, Actin, AD
KG Connections	1656 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RB1 — AlphaFold P06400 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (17)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RB1["RB1"] -->|"interacts"| Dementia["Dementia"]
    RB1["RB1"] -->|"interacts"| Cardiovascular["Cardiovascular"]
    RB1["RB1"] -->|"interacts"| Als["Als"]
    RB1["RB1"] -->|"interacts"| Alzheimer["Alzheimer"]
    RB1["RB1"] -->|"interacts"| Parkinson["Parkinson"]
    RB1["RB1"] -->|"interacts"| Ms["Ms"]
    CAT["CAT"] -->|"interacts"| RB1["RB1"]
    OPTN["OPTN"] -->|"interacts"| RB1["RB1"]
    DNM1L["DNM1L"] -->|"interacts"| RB1["RB1"]
    CANX["CANX"] -->|"interacts"| RB1["RB1"]
    style RB1 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (822)

Target	Relation	Type	Str
retinoblastoma	causes	disease	0.95
small cell lung carcinoma	risk_factor_for	disease	0.95
ESCC	causes	disease	0.90
cell cycle	regulates	pathway	0.90
DNMT1	regulates	gene	0.80
TERRA	regulates	gene	0.80
neural stem cells	activates	cell_type	0.80
second cancer	contributes_to	disease	0.80
ubiquitin-proteasome	participates_in	pathway	0.80
neural stem cells	regulates	cell_type	0.80
oxidative stress response	participates_in	pathway	0.80
Autophagy	associated_with	pathway	0.80
AUTOPHAGY	associated_with	gene	0.80
LC3	associated_with	gene	0.80
RB1CC1	associated_with	gene	0.80
Parkinson	associated_with	disease	0.75
Als	associated_with	disease	0.75
Tumor	associated_with	disease	0.75
Tumor	inhibits	disease	0.75
Cancer	activates	disease	0.75
Tumor	therapeutic_target	disease	0.75
Cancer	therapeutic_target	disease	0.75
Aging	therapeutic_target	disease	0.75
Hepatocellular Carcinoma	suppresses	disease	0.72
Apoptosis	associated_with	pathway	0.70
VAMP8	activates	gene	0.70
SNAP29	activates	gene	0.70
SNAP29	regulates	gene	0.70
Notch signaling	participates_in	pathway	0.70
STX17	activates	gene	0.70
STING1	regulates	gene	0.70
STX17	regulates	gene	0.70
STING1	activates	gene	0.70
TFEB	associated_with	gene	0.70
UBIQUITIN	associated_with	gene	0.70
GABARAP	associated_with	gene	0.70
RTN3	activates	gene	0.70
Cyclin D1	regulates	gene	0.70
GLUT1 inhibitor sensitivity	regulates	process	0.70
Cyclin E1	regulates	gene	0.70
hippocampal inflammation	inhibits	process	0.70
neurodegeneration	protects_against	process	0.70
oxidative phosphorylation	regulates	process	0.70
GLUT1 inhibition sensitivity	biomarker_for	biomarker_for	0.70
p21Cip1	regulates	gene	0.70
p16INK4a	regulates	gene	0.70
NF-κB signaling pathway	regulates	pathway	0.70
HO-1/Nrf2	activates	pathway	0.70
ROS/TXNIP/NLRP3	inhibits	pathway	0.70
age-related cognitive impairment	treats	disease	0.70

Incoming (846)

Source	Relation	Type	Str
TP53	coexpressed_with	gene	0.85
NBR1	activates	gene	0.80
NBR1	regulates	gene	0.80
OPTN	regulates	gene	0.80
ATG	regulates	gene	0.80
rapamycin	targets	drug	0.80
RB1CC1	regulates	gene	0.80
FIP200	regulates	gene	0.80
FGFR3	interacts_with	gene	0.70
GABARAP	regulates	gene	0.70
BECN1	associated_with	gene	0.70
DNA	regulates	gene	0.70
CANCER	activates	gene	0.70
ERN1	regulates	gene	0.70
DNM1L	regulates	gene	0.70
AMPK	regulates	gene	0.70
FIP200	associated_with	gene	0.70
P16	regulates	protein	0.70
CDK4	interacts_with	protein	0.70
DDIT3	regulates	gene	0.70
EIF2AK3	regulates	gene	0.70
P53	inhibits	gene	0.70
NDP52	activates	gene	0.70
PRKN	activates	gene	0.70
TP53	activates	gene	0.70
CANCER	therapeutic_target	gene	0.70
NLR	activates	gene	0.70
GABA	regulates	gene	0.70
CALCOCO2	regulates	gene	0.70
GABA	activates	gene	0.70
EIF2AK3	activates	gene	0.70
NLR	regulates	gene	0.70
PRKN	regulates	gene	0.70
PIK3C3	activates	gene	0.70
NDP52	regulates	gene	0.70
JNK	regulates	gene	0.70
ERN1	activates	gene	0.70
PIK3C3	regulates	gene	0.70
CALCOCO2	activates	gene	0.70
MAP1LC3B	regulates	gene	0.70
GABARAP	activates	gene	0.70
DNM1L	activates	gene	0.70
RAPAMYCIN	activates	drug	0.65
LRRK2	regulates	gene	0.60
MSH2	expressed_in	gene	0.60
MLKL	regulates	gene	0.60
FGFR1	therapeutic_target	gene	0.60
AKT	activates	gene	0.60
BECN1	interacts_with	gene	0.60
BRAF	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

RB1

Understanding Entity Pages

Summary

Wiki Pages (17)

RB1 — Retinoblastoma 1

GIGYF2 — GRB10 Interacting GYF Protein 2

ADRB1 Gene

ARRB1 — Arrestin Beta 1

GIGYF2 Protein (GRB10-Interacting GYF Protein 2)

ARRB1 Protein — Arrestin Beta 1

HLA-DRB1 Protein

ADARB1 Protein (Adenosine Deaminase Acting on RNA 1)

RB1CC1 Gene

RB1 Protein (Retinoblastoma Protein)

HLA-DRB1 — MHC Class II DR Beta 1

DYNLRB1 Gene

HLA-DRB1 Gene

SCARB1 Protein (Scavenger Receptor Class B Type 1)