concept

STEM CELLS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STEM CELLS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

861Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	STEM CELLS
Key Genes/Proteins	ABL1, ACSL4, acvr1, ADORA2A, AKT, ALZHEIMER
Related Diseases	aging, ALS, Alzheimer Disease, Alzheimer'S Disease, ALZHEIMER'S DISEASE

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SVZ Neural Stem Cells

cell · 1290 words

→

Pathway Diagram

graph TD
    STEM_CELLS["STEM CELLS"]
    STEM_CELLS -->|"activates"| TDP_43["TDP-43"]
    STEM_CELLS -->|"activates"| TAU["TAU"]
    STEM_CELLS -->|"activates"| TFEB["TFEB"]
    STEM_CELLS -->|"treats"| Parkinson_s_Disease["Parkinson's Disease"]
    STEM_CELLS -->|"activates"| STING["STING"]
    STEM_CELLS -->|"activates"| UBIQUITIN["UBIQUITIN"]
    STEM_CELLS -->|"activates"| UNFOLDED_PROTEIN_RESPONSE["UNFOLDED PROTEIN RESPONSE"]
    STEM_CELLS -->|"activates"| ULK1["ULK1"]
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| STEM_CELLS
    CANCER["CANCER"] -->|"activates"| STEM_CELLS
    RAPAMYCIN["RAPAMYCIN"] -->|"activates"| STEM_CELLS
    SQSTM1["SQSTM1"] -->|"activates"| STEM_CELLS
    BECN1["BECN1"] -->|"activates"| STEM_CELLS
    MTOR["MTOR"] -->|"activates"| STEM_CELLS
    MOTOR_NEURONS["MOTOR NEURONS"] -->|"activates"| STEM_CELLS
    IPSC["IPSC"] -->|"activates"| STEM_CELLS

Outgoing (82)

Target	Relation	Type	Str
Neural Tissue Damage	treats	phenotype	0.95
TDP-43	activates	gene	0.95
TAU	activates	protein	0.95
Neural Tissue Repair	mediates	process	0.92
Stroke	treats	disease	0.90
Parkinson'S Disease	treats	disease	0.90
Alzheimer'S Disease	treats	disease	0.90
Amyotrophic Lateral Sclerosis	treats	disease	0.90
Multiple Sclerosis	treats	disease	0.90
Spinal Cord Injury	treats	disease	0.90
TFEB	activates	gene	0.80
PROTECTIVE EFFECTS	exerts	phenotype	0.80
neurodegenerative disorders	treats	disease	0.80
Neuron	mediates	cell_type	0.80
oxidative stress response	active_in	pathway	0.75
autophagy pathway	active_in	pathway	0.75
circadian regulation	active_in	pathway	0.75
ASTROCYTES	interacts_with	cell_type	0.70
MYC	activates	gene	0.70
NEURON	treats	cell_type	0.70
IMATINIB	interacts_with	drug	0.65
NEURONS	protects_against	cell_type	0.65
EGF	activates	gene	0.65
ABL1	targets	gene	0.65
IMATINIB	inhibits	drug	0.65
CANCER	exacerbates	disease	0.65
ENDOPLASMIC RETICULUM STRESS	treats	phenotype	0.65
Parkinson's Disease	treats	disease	0.65
neurotrophin signaling	active_in	pathway	0.65
ASTROGLIOSIS	causes	phenotype	0.65
NAD+ metabolism	active_in	pathway	0.55
NEURONS	expressed_in	cell_type	0.55
unfolded protein response	active_in	pathway	0.55
Wnt signaling	active_in	pathway	0.55
purinergic signaling	active_in	pathway	0.55
EXTRACELLULAR VESICLES	interacts_with	concept	0.50
EXTRACELLULAR VESICLES	associated_with	concept	0.50
ENDOPLASMIC RETICULUM	inhibits	concept	0.50
EXTRACELLULAR VESICLES	regulates	concept	0.50
ENDOPLASMIC RETICULUM	regulates	concept	0.50
DENDRITE	activates	concept	0.50
MTOR SIGNALING	inhibits	concept	0.50
B CELLS	activates	concept	0.50
DENDRITIC CELLS	activates	concept	0.50
DOPAMINERGIC NEURONS	associated_with	concept	0.50
DOPAMINERGIC NEURONS	activates	concept	0.50
NEUTROPHILS	activates	concept	0.50
RAPAMYCIN	activates	concept	0.50
PEROXISOME	activates	concept	0.50
IPSC	associated_with	concept	0.50

Incoming (779)

Source	Relation	Type	Str
SQSTM1	activates	gene	0.95
RAPAMYCIN	activates	drug	0.95
AUTOPHAGY	activates	process	0.95
BECN1	activates	gene	0.95
MTOR	activates	gene	0.95
CANCER	activates	disease	0.95
PARKINSON'S DISEASE	activates	disease	0.95
NEURON	activates	cell_type	0.95
MICROGLIA	activates	cell_type	0.95
ASTROCYTES	activates	cell_type	0.95
FRONTOTEMPORAL DEMENTIA	activates	disease	0.95
FIBROBLASTS	activates	cell_type	0.95
IPSC	activates	cell_type	0.95
ORGANOIDS	activates	cell_type	0.95
NEURODEGENERATION	activates	process	0.95
CORTEX	activates	brain_region	0.95
ALS	activates	disease	0.95
MOTOR NEURONS	activates	cell_type	0.95
GBM	expressed_in	gene	0.90
Wnt pathway	regulates	pathway	0.90
RNA	expressed_in	gene	0.90
ALS	expressed_in	gene	0.90
SQSTM1	expressed_in	gene	0.90
DNA	expressed_in	gene	0.90
PINK1	expressed_in	gene	0.80
MIP	supports	protein	0.80
ABCA7	expressed_in	gene	0.80
SORL1	expressed_in	gene	0.80
MAP1LC3	expressed_in	gene	0.80
KGF	supports	protein	0.80
EGF	supports	protein	0.80
VEGF-Α	supports	protein	0.80
TGF	supports	protein	0.80
OLIG2	expressed_in	gene	0.80
MACROPHAGES	activates	cell_type	0.80
NEURON	regulates	cell_type	0.80
AGING	activates	process	0.80
STAT3	activates	gene	0.80
LC3	activates	gene	0.80
NEURON	interacts_with	cell_type	0.80
CANCER	associated_with	disease	0.80
MTOR	expressed_in	gene	0.80
STAT3	expressed_in	gene	0.80
BECN1	expressed_in	gene	0.80
APOE	expressed_in	gene	0.80
APOE4	expressed_in	gene	0.80
ROS	expressed_in	gene	0.80
IFN	expressed_in	gene	0.80
LC3	expressed_in	gene	0.80
TFEB	expressed_in	gene	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning STEM CELLS in their description or question text

No additional research found